Gene: RIPOR2

9750
C6orf32|DFNB104|DIFF40|DIFF48|FAM65B|MYONAP|PL48
RHO family interacting cell polarization regulator 2
protein-coding
6p22.3
Ensembl:ENSG00000111913 MIM:611410 Vega:OTTHUMG00000191459 UniprotKB:Q9Y4F9
NG_051606.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.214e-1 (AD)  1.413e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4256430chr6:24862847 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of RIPOR2 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RIPOR2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RIPOR2 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RIPOR2 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of RIPOR2 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RIPOR2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of RIPOR2 mRNA26705709
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of RIPOR2 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of RIPOR2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RIPOR2 mRNA19770486
C006780bisphenol Abisphenol A affects the expression of RIPOR2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of RIPOR2 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of RIPOR2 mRNA25047013
C006780bisphenol Abisphenol A affects the expression of RIPOR2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of RIPOR2 mRNA20147733
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RIPOR2 mRNA25993096
D002220CarbamazepineCarbamazepine affects the expression of RIPOR2 mRNA25979313
D002737ChloropreneChloroprene results in decreased expression of RIPOR2 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of RIPOR2 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of RIPOR2 mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of RIPOR2 mRNA12782123
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of RIPOR2 mRNA21852083
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of RIPOR2 mRNA24535843
D004237DiuronDiuron results in increased expression of RIPOR2 mRNA25152437
C118739entinostatentinostat results in increased expression of RIPOR2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RIPOR2 mRNA18936297
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of RIPOR2 mRNA23649840
C039281furanfuran results in increased expression of RIPOR2 mRNA26194646
D019833GenisteinGenistein results in decreased expression of RIPOR2 mRNA26865667
D005839GentamicinsGentamicins results in increased expression of RIPOR2 mRNA22061828
D017313FenretinideFenretinide results in increased expression of RIPOR2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RIPOR2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RIPOR2 mRNA23086925
C561695(+)-JQ1 compoundRIPOR2 promoter modified form results in increased susceptibility to (+)-JQ1 compound26752646
D008558MelphalanMelphalan results in decreased expression of RIPOR2 mRNA22363485
C042720mercuric bromidemercuric bromide results in increased expression of RIPOR2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of RIPOR2 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RIPOR2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RIPOR2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RIPOR2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RIPOR2 mRNA"25554681
D009532NickelNickel results in decreased expression of RIPOR2 mRNA23195993
D009532NickelNickel results in increased expression of RIPOR2 mRNA24768652|2558310
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RIPOR2 mRNA25729387
D010126OzoneOzone results in decreased expression of RIPOR2 mRNA28623178
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of RIPOR2 mRNA23602845
D010634PhenobarbitalPhenobarbital affects the expression of RIPOR2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RIPOR2 mRNA26272509
D011374ProgesteroneProgesterone affects the expression of RIPOR2 mRNA19690047
D011374ProgesteroneProgesterone results in increased expression of RIPOR2 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of RIPOR2 mRNA24780913
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RIPOR2 mRNA19059307
C059514resveratrolresveratrol results in decreased expression of RIPOR2 mRNA12002526
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of RIPOR2 mRNA21852083
D012834SilverSilver results in decreased expression of RIPOR2 mRNA27131904
D012906SmokeSmoke results in increased expression of RIPOR2 mRNA21095227
D053260SootSoot results in decreased expression of RIPOR2 mRNA26551751
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of RIPOR2 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RIPOR2 mRNA20106945
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RIPOR2 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RIPOR2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RIPOR2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of RIPOR2 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of RIPOR2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RIPOR2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of RIPOR2 mRNA23179753|2438349
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of RIPOR2 mRNA"24525044

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21988832  24687993  25416956  
GO:007188914-3-3 protein binding-IDA24687993  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007162negative regulation of cell adhesion-IMP23241886  
GO:0007162negative regulation of cell adhesion-ISS-  
GO:0007605sensory perception of sound-IMP24958875  
GO:0035024negative regulation of Rho protein signal transduction-IMP23241886  
GO:0035024negative regulation of Rho protein signal transduction-ISS-  
GO:0045663positive regulation of myoblast differentiation-IMP17150207  
GO:0048741skeletal muscle fiber development-IEA-  
GO:0051491positive regulation of filopodium assembly-IMP17150207  
GO:0090023positive regulation of neutrophil chemotaxis-ISS-  
GO:1901741positive regulation of myoblast fusion-IMP17150207  
GO:1903904negative regulation of establishment of T cell polarity-IMP23241886  
GO:1905872negative regulation of protein localization to cell leading edge-ISS-  
GO:1990869cellular response to chemokine-IDA23241886  
GO:2000114regulation of establishment of cell polarity-ISS-  
GO:2000391positive regulation of neutrophil extravasation-ISS-  
GO:2000405negative regulation of T cell migration-IMP23241886  
GO:2001107negative regulation of Rho guanyl-nucleotide exchange factor activity-IMP23241886  
GO:2001107negative regulation of Rho guanyl-nucleotide exchange factor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA17150207  23241886  24687993  
GO:0005856cytoskeleton-IDA17150207  
GO:0016324apical plasma membrane-IEA-  
GO:0030175filopodium-IDA17150207  
GO:0032420stereocilium-ISS-  
GO:0060171stereocilium membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal