Gene: SNPH

9751
-
syntaphilin
protein-coding
20p13
Ensembl:ENSG00000101298 MIM:604942 Vega:OTTHUMG00000031662 UniprotKB:O15079
NC_000020.11
PubMed
0   ANCO-SNPs
CD
1   
9.725e-1 (AD)  2.726e-1 (ND)   (Frontal_Cortex)
7.891e-1 (AD)  1.465e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNAB20.967
DMTN0.959
PACSIN10.958
CAMK2A0.956
CTIF0.956
ZER10.954
LZTS30.947
RUSC20.947
DLG40.945
KNDC10.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.663
OR4F29-0.613
TFPI2-0.53
C9orf135-0.471
SGMS2-0.467
ANXA13-0.442
RAI14-0.438
IGF2BP2-0.436
SH2D1A-0.428
SNHG18-0.427

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SNPH mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of SNPH mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SNPH mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SNPH gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SNPH mRNA24449571
C006780bisphenol Abisphenol A results in decreased expression of SNPH mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of SNPH protein28903499
D003042CocaineCocaine affects the expression of SNPH mRNA20187946
C544151jinfukangjinfukang results in increased expression of SNPH mRNA27392435
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SNPH mRNA"20188158
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SNPH mRNA27935865
D012906SmokeSmoke results in increased expression of SNPH mRNA21095227
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SNPH gene27618143
D014635Valproic AcidValproic Acid results in increased expression of SNPH mRNA28001369
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SNPH mRNA27935865
C088658zoledronic acidzoledronic acid results in increased expression of SNPH mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017075syntaxin-1 binding-NAS10707983  
GO ID GO Term Qualifier Evidence PubMed
GO:0007269neurotransmitter secretion-NAS10707983  
GO:0007420brain development-IEA-  
GO:0016081synaptic vesicle docking-NAS10707983  
GO:0030182neuron differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA15459722  
GO:0005881cytoplasmic microtubule-IDA23264731  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0031966mitochondrial membrane-IEA-  
GO:0042734presynaptic membrane-IEA-  
GO:0043005neuron projection-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry