Gene: ZSCAN12

9753
ZFP96|ZNF29K1|ZNF305|ZNF96|dJ29K1.2
zinc finger and SCAN domain containing 12
protein-coding
6p22.1
Ensembl:ENSG00000158691 MIM:603978 Vega:OTTHUMG00000014522 UniprotKB:O43309
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.957e-1 (AD)  9.752e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPAT0.87
CTDSPL20.866
WDFY10.865
CCNT10.858
JMJD1C0.855
BTAF10.85
SUZ120.842
DIS30.842
TMF10.84
RBM270.84

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.438
OR4F29-0.412
LCN1-0.249
S100A1-0.24
PLA2G5-0.239
NEU4-0.236
BTBD17-0.219
HES5-0.214
TMEM253-0.208
HPR-0.207

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN12 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZSCAN12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZSCAN12 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ZSCAN12 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ZSCAN12 mRNA16483693
C006780bisphenol Abisphenol A affects the methylation of ZSCAN12 promoter27334623
C037123cadmium sulfatecadmium sulfate results in decreased expression of ZSCAN12 mRNA19274763
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ZSCAN12 mRNA25270620
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZSCAN12 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ZSCAN12 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ZSCAN12 gene20938992
C014347decitabine[decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of ZSCAN12 promoter]18448484
C014347decitabinedecitabine inhibits the reaction [sodium arsenite affects the methylation of ZSCAN12 promoter]18448484
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZSCAN12 mRNA27392435
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ZSCAN12 mRNA23649840
D005419FlavonoidsFlavonoids results in decreased expression of ZSCAN12 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ZSCAN12 gene20938992
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZSCAN12 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ZSCAN12 mRNA27392435
C045463leflunomideleflunomide results in increased expression of ZSCAN12 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ZSCAN12 gene20938992
D008727MethotrexateMethotrexate results in increased expression of ZSCAN12 mRNA24449571
D008752Methylene ChlorideMethylene Chloride results in decreased expression of ZSCAN12 mRNA28392392
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZSCAN12 mRNA23649840
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of ZSCAN12 promoter18448484
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of ZSCAN12 mRNA18448484
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ZSCAN12 mRNA"25554681
D010634PhenobarbitalPhenobarbital affects the expression of ZSCAN12 mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of ZSCAN12 mRNA23557933
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ZSCAN12 mRNA25351596
C017947sodium arsenite[decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of ZSCAN12 promoter]18448484
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite affects the methylation of ZSCAN12 promoter]18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of ZSCAN12 promoter18448484
C017947sodium arsenitesodium arsenite results in decreased expression of ZSCAN12 mRNA18448484
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZSCAN12 mRNA24058054
D013792ThalidomideThalidomide results in decreased expression of ZSCAN12 mRNA26217789
C012589trichostatin A[decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of ZSCAN12 promoter]18448484
C057693troglitazonetroglitazone results in increased expression of ZSCAN12 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZSCAN12 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ZSCAN12 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of ZSCAN12 mRNA26272509
C111237vorinostatvorinostat results in increased expression of ZSCAN12 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27142338Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes. (2016 Jul 15)Shui IMCancer