Gene info: ID 9759

Gene: HDAC4

GENE ID: 9759

Description: histone deacetylase 4

Gene type: protein-coding

Location: 2q37.3

dbXrefs: Ensembl:ENSG00000068024 MIM:605314 Vega:OTTHUMG00000133344 UniprotKB:P56524

RefSeq: NG_009235.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.401e-1 (AD) 8.060e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg27583104	chr2:240299910	HDAC4	Promoter	3.034e-4	Alcohol use disorders	26763658
cg02173540	chr2:240046504	HDAC4	Gene body	4.406e-4	Alcohol use disorders	26763658
cg11550064	chr2:240148191	HDAC4		1.700e-9	Smoking	27651444
cg14615927	chr2:240259213	HDAC4		1.130e-10	Alcohol consumption per day	27843151
cg26078407	chr2:240225062	HDAC4		3.160e-8	Alcohol consumption per day	27843151
cg05903736	chr2:240197131	HDAC4		2.890e-9	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FAM53C	0.88
NMT1	0.873
UBE4B	0.872
HINFP	0.867
FBXO42	0.863
STK35	0.862
FLCN	0.861
TBCK	0.86
ZNF74	0.86
CBFA2T2	0.859

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.484
OR4F29	-0.457
TFPI2	-0.424
KLRF1	-0.424
KLRB1	-0.413
TBX21	-0.38
C9orf135	-0.376
CD3G	-0.375
IL2RB	-0.373
CNGA1	-0.372

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB06176	Romidepsin	Small Molecule	128517-07-7	Approved\|Investigational	Target
DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide	Small Molecule		Experimental	Target
DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL	Small Molecule		Experimental	Target
DB05015	Belinostat	Small Molecule	866323-14-0	Approved\|Investigational	Target
DB06603	Panobinostat	Small Molecule	404950-80-7	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of HDAC4 mRNA	28329830
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of HDAC4 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of HDAC4 mRNA	21641981
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HDAC4 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in increased expression of HDAC4 protein	16483693
D001151	Arsenic	Arsenic affects the expression of HDAC4 mRNA	25304211
D001151	Arsenic	Arsenic affects the methylation of HDAC4 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of HDAC4 mRNA	22521957
D001241	Aspirin	Aspirin results in increased expression of HDAC4 mRNA	15928584
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HDAC4 mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HDAC4 mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HDAC4 mRNA"	26238291
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of HDAC4 mRNA	20404318
C006780	bisphenol A	bisphenol A affects the expression of HDAC4 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of HDAC4 mRNA	29027980
C006780	bisphenol A	bisphenol A affects the methylation of HDAC4 promoter	27334623
C006780	bisphenol A	bisphenol A results in increased methylation of HDAC4 gene	28505145
D000069286	Bortezomib	Bortezomib results in decreased expression of HDAC4 mRNA	17659339
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HDAC4 mRNA	27396813
C006963	chlamydocin	chlamydocin analog results in decreased activity of HDAC4 protein	16439135
D002922	Ciguatoxins	Ciguatoxins affects the expression of HDAC4 mRNA	18353800
D003474	Curcumin	Curcumin analog results in decreased expression of HDAC4 mRNA	26409325
D003474	Curcumin	Curcumin analog results in decreased expression of HDAC4 protein	26991801
D016572	Cyclosporine	Cyclosporine results in decreased expression of HDAC4 mRNA	25562108
C014347	decitabine	decitabine results in increased expression of HDAC4 mRNA	27915011
D003907	Dexamethasone	Dexamethasone results in increased expression of HDAC4 mRNA	19022236
D002945	Cisplatin	Cisplatin results in decreased expression of HDAC4 mRNA	19561079
D002945	Cisplatin	HDAC4 results in decreased susceptibility to Cisplatin	21571862
D002945	Cisplatin	[HDAC4 results in increased activity of STAT1] which results in decreased susceptibility to Cisplatin	21571862
C000944	dicrotophos	dicrotophos results in increased expression of HDAC4 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of HDAC4 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in decreased expression of HDAC4 mRNA	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HDAC4 mRNA	25068794
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HDAC4 protein	25068794
D004051	Diethylhexyl Phthalate	HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased acetylation of and results in increased ubiquitination of SP3 protein]	25068794
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of HDAC4 protein	25068794
D004051	Diethylhexyl Phthalate	HDAC4 mutant form inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SP3 protein]	25068794
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of HDAC4 mRNA	26924002
D004726	Endosulfan	Endosulfan results in decreased expression of HDAC4 mRNA	29054638
D004726	Endosulfan	Endosulfan results in decreased expression of HDAC4 protein	29054638
C031818	enterotoxin B, staphylococcal	"enterotoxin B, staphylococcal results in decreased expression of HDAC4 mRNA"	24200994
C031818	enterotoxin B, staphylococcal	"indole-3-carbinol promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC4 mRNA]"	24200994
D004967	Estrogens	HDAC4 protein inhibits the reaction [Estrogens results in increased activity of ESR1 protein]	16051668
D000431	Ethanol	Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]	23544086
D000431	Ethanol	Ethanol results in increased expression of HDAC4 protein	23544086
D000431	Ethanol	tauroursodeoxycholic acid inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]	23544086
D000431	Ethanol	tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of HDAC4 protein]	23544086
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HDAC4 mRNA	29097150
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of HDAC4 mRNA	23649840
D005047	Etoposide	HDAC4 protein affects the susceptibility to Etoposide	16217747
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of HDAC4 mRNA	28329830
D005472	Fluorouracil	Fluorouracil results in decreased expression of HDAC4 mRNA	16557594
D005557	Formaldehyde	Formaldehyde results in decreased expression of HDAC4 mRNA	23649840
D005839	Gentamicins	Gentamicins results in increased expression of HDAC4 protein	19141081\|2355823
C010974	glyphosate	glyphosate results in decreased expression of HDAC4 mRNA	25636363
C016517	indole-3-carbinol	"indole-3-carbinol promotes the reaction [enterotoxin B, staphylococcal results in decreased expression of HDAC4 mRNA]"	24200994
C577554	MC1568	MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein]	27660204
C577554	MC1568	MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein]	27660204
D008727	Methotrexate	HDAC4 protein affects the susceptibility to Methotrexate	16217747
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of HDAC4 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of HDAC4 mRNA	23649840
D008942	Mitoxantrone	HDAC4 protein affects the susceptibility to Mitoxantrone	16217747
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of HDAC4 mRNA	23891734
C406082	monomethylarsonous acid	[vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC4 mRNA	23891734
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of HDAC4 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of HDAC4 mRNA	26392148
C028473	N-acetyl-4-benzoquinoneimine	HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine	21177773
C028007	nickel monoxide	nickel monoxide results in decreased expression of HDAC4 mRNA	19167457
D009543	Nifedipine	Nifedipine affects the localization of HDAC4 protein	20559781
D017239	Paclitaxel	Paclitaxel results in decreased expression of HDAC4 protein	27474498
D000073878	Palm Oil	Palm Oil results in decreased expression of HDAC4 mRNA	18042831
D010269	Paraquat	Paraquat results in decreased expression of HDAC4 protein	21777615
C410127	PCB 180	PCB 180 affects the expression of HDAC4 mRNA	21703328
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of HDAC4 mRNA	17097637
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of HDAC4 mRNA	26272509
D011794	Quercetin	Quercetin results in decreased expression of HDAC4 mRNA	20596804
C087123	romidepsin	romidepsin results in decreased activity of HDAC4 protein	25699604
D020845	Selective Estrogen Receptor Modulators	HDAC4 protein inhibits the reaction [Selective Estrogen Receptor Modulators results in increased activity of ESR1 protein]	16051668
C017947	sodium arsenite	sodium arsenite results in increased expression of HDAC4 mRNA	21503876
D013629	Tamoxifen	HDAC4 protein inhibits the reaction [Tamoxifen results in increased activity of ESR1 protein]	16051668
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]	23544086
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of HDAC4 protein]	23544086
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of HDAC4 mRNA	27914987
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HDAC4 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HDAC4 mRNA	22493514
D013849	Thimerosal	MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein]	27660204
D013849	Thimerosal	Thimerosal results in increased expression of HDAC4 protein	27660204
D013849	Thimerosal	MC1568 inhibits the reaction [Thimerosal results in increased expression of HDAC4 protein]	27660204
D013849	Thimerosal	Thimerosal results in increased expression of HDAC4 protein	27660204
C009495	titanium dioxide	titanium dioxide results in increased expression of HDAC4 mRNA	23131501
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of HDAC4 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HDAC4 mRNA	28111298
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of HDAC4 mRNA	22723015\|2493525
C012589	trichostatin A	trichostatin A results in decreased activity of HDAC4 protein	25699604
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HDAC4 mRNA"	26179874
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HDAC4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of HDAC4 mRNA	26272509\|2800136
D014635	Valproic Acid	Valproic Acid results in increased methylation of HDAC4 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of HDAC4 gene	25487561
C025643	vinclozolin	vinclozolin affects the expression of HDAC4 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of HDAC4 mRNA	18042343
D014750	Vincristine	Vincristine results in decreased expression of HDAC4 protein	27474498
C111237	vorinostat	[vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC4 mRNA	23891734
C111237	vorinostat	vorinostat results in decreased activity of HDAC4 protein	17988634
D015032	Zinc	Zinc binds to and results in increased activity of HDAC4 protein	16439135

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	24413532
GO:0001085	RNA polymerase II transcription factor binding	-	IPI	23867755
GO:0003714	transcription corepressor activity	-	IEA	-
GO:0004407	histone deacetylase activity	-	IDA	10220385 10869435
GO:0005515	protein binding	-	IPI	10869435 10958686 11463856 11504882 11804585 15161933 15194749 15324660 15778465 15964851 16147992 16166628 16767219 16919237 17159145 17353931 17979178 18045992 18163532 20116378 20936779 21242980 21988832 22649097 23752268 24229708 24255178 24413532 25416956 26496610 27708256
GO:0008134	transcription factor binding	-	IPI	18850004 19071119
GO:0008270	zinc ion binding	-	IDA	18614528
GO:0019901	protein kinase binding	-	IEA	-
GO:0030955	potassium ion binding	-	IDA	18614528
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	-	IEA	-
GO:0033558	protein deacetylase activity	-	IDA	18614528
GO:0033558	protein deacetylase activity	-	TAS	-
GO:0033613	activating transcription factor binding	-	IPI	10983972
GO:0042802	identical protein binding	-	IPI	17360518
GO:0042826	histone deacetylase binding	-	IPI	10869435 12590135
GO:0043565	sequence-specific DNA binding	contributes_to	IDA	19276356
GO:0044212	transcription regulatory region DNA binding	contributes_to	IDA	18850004
GO:0070491	repressing transcription factor binding	-	IPI	11804585
GO:1990841	promoter-specific chromatin binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	10869435 16236793
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IGI	15743821
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	18850004 19276356
GO:0001501	skeletal system development	-	IEA	-
GO:0002076	osteoblast development	-	IEA	-
GO:0006338	chromatin remodeling	-	IDA	18850004
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006476	protein deacetylation	-	IDA	27708256
GO:0006954	inflammatory response	-	TAS	12711221
GO:0007399	nervous system development	-	TAS	12711221
GO:0008284	positive regulation of cell proliferation	-	IMP	18850004
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0010592	positive regulation of lamellipodium assembly	-	IEA	-
GO:0010832	negative regulation of myotube differentiation	-	IMP	10983972
GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	-	IEA	-
GO:0014894	response to denervation involved in regulation of muscle adaptation	-	ISS	-
GO:0014898	cardiac muscle hypertrophy in response to stress	-	TAS	17011572
GO:0014911	positive regulation of smooth muscle cell migration	-	IEA	-
GO:0016575	histone deacetylation	-	IDA	10869435
GO:0016575	histone deacetylation	-	IMP	18850004
GO:0030183	B cell differentiation	-	TAS	12711221
GO:0033235	positive regulation of protein sumoylation	-	IDA	17696781
GO:0034983	peptidyl-lysine deacetylation	-	IDA	18614528
GO:0040029	regulation of gene expression, epigenetic	-	IMP	24413532
GO:0042113	B cell activation	-	TAS	12711221
GO:0042493	response to drug	-	IEA	-
GO:0043393	regulation of protein binding	-	IMP	19071119
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IMP	18850004
GO:0043525	positive regulation of neuron apoptotic process	-	IEA	-
GO:0045668	negative regulation of osteoblast differentiation	-	IEA	-
GO:0045820	negative regulation of glycolytic process	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	10869435
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	19276356
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	19071119
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IEA	-
GO:0048742	regulation of skeletal muscle fiber development	-	IEA	-
GO:0051091	positive regulation of DNA-binding transcription factor activity	-	IMP	19071119
GO:0070555	response to interleukin-1	-	IMP	19281832
GO:0070932	histone H3 deacetylation	-	IDA	12590135
GO:0070933	histone H4 deacetylation	-	IDA	12590135
GO:0071260	cellular response to mechanical stimulus	-	IEA	-
GO:0071356	cellular response to tumor necrosis factor	-	IEA	-
GO:0071374	cellular response to parathyroid hormone stimulus	-	IEA	-
GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	-	IEA	-
GO:1903428	positive regulation of reactive oxygen species biosynthetic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000118	histone deacetylase complex	-	IDA	11804585
GO:0005634	nucleus	-	IDA	10869435 19281832 23867755 26019235
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IDA	10869435 19281832
GO:0005829	cytosol	-	IDA	-
GO:0017053	transcriptional repressor complex	-	IDA	11804585
GO:0030018	Z disc	-	IEA	-
GO:0031594	neuromuscular junction	-	IEA	-
GO:0031672	A band	-	IEA	-
GO:0042641	actomyosin	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-1643685	Disease	TAS
R-HSA-1980143	Signaling by NOTCH1	IEA
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	TAS
R-HSA-2644603	Signaling by NOTCH1 in Cancer	TAS
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	TAS
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	TAS
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	TAS
R-HSA-2990846	SUMOylation	TAS
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-4551638	SUMOylation of chromatin organization proteins	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8941284	RUNX2 regulates chondrocyte maturation	IEA
R-HSA-8941326	RUNX2 regulates bone development	IEA
R-HSA-8951936	RUNX3 regulates p14-ARF	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20471694	Association of histone deacetylase genes with schizophrenia in Korean population. (2010 Jul 30)	Kim T	Psychiatry Res
25814047	Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. (2015 Oct)	Pandey SC	Neurobiol Dis
29109977	Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5. (2017 Nov)	Griffin EA Jr	Sci Adv
23488934	Blockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum. (2013 Jul)	Legastelois R	Alcohol Clin Exp Res
24528596	Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. (2014 Aug)	Sakharkar AJ	Int J Neuropsychopharmacol
26437241	The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema. (2015 Nov)	Lu W	Nat Immunol
29191063	Changes in DNA methylation induced by multi-walled carbon nanotube exposure in the workplace. (2017 Nov - Dec)	Ghosh M	Nanotoxicology