Gene info: ID 9760

Gene: TOX

GENE ID: 9760

Synonyms: TOX1

Description: thymocyte selection associated high mobility group box

Gene type: protein-coding

Location: 8q12.1

dbXrefs: Ensembl:ENSG00000198846 MIM:606863 Vega:OTTHUMG00000164331 UniprotKB:O94900

RefSeq: NG_011993.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.128e-1 (AD) 2.635e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs422729	chr8:58995470 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg02892925	chr8:60032926	TOX		8.430e-10	Maternal smoking in pregnancy	27040690
cg02892925	chr8:60032926	TOX		2.910e-11	Maternal smoking in pregnancy	27040690
cg07211044	chr8:60032983	TOX		8.000e-9	Maternal smoking in pregnancy	27040690
cg02892925	chr8:60032926	TOX		6.570e-9	Maternal smoking in pregnancy	27040690
cg07211044	chr8:60032983	TOX		7.620e-9	Maternal smoking in pregnancy	27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RORB	0.871
MAGI3	0.863
FAM155A	0.844
RNF38	0.843
CADM2	0.839
TMED8	0.839
EFR3A	0.839
FAM217B	0.839
NRCAM	0.837
PCYOX1	0.833

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.509
OR4F29	-0.467
EVA1A	-0.4
SH2D1A	-0.366
MDFI	-0.36
RAI14	-0.35
TFPI2	-0.337
CXCL3	-0.335
TSLP	-0.333
SGMS2	-0.326

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TOX mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of TOX mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of TOX mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of TOX mRNA	26690555
D020106	Acrylamide	Acrylamide results in increased expression of TOX mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TOX gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of TOX mRNA	19770486
C015001	arsenite	arsenite results in increased methylation of TOX promoter	23974009
D001280	Atrazine	Atrazine results in decreased expression of TOX mRNA	25929836
D001280	Atrazine	Atrazine results in decreased expression of TOX mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TOX mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of TOX mRNA	19770486\|2171566
D004958	Estradiol	Estradiol affects the expression of TOX mRNA	22574217
C006780	bisphenol A	bisphenol A results in decreased expression of TOX mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased expression of TOX mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased methylation of TOX gene	22576693
C006780	bisphenol A	bisphenol A affects the expression of TOX mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of TOX gene	28505145
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TOX mRNA	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of TOX mRNA	19320972
D016572	Cyclosporine	Cyclosporine results in increased expression of TOX mRNA	19770486
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of TOX mRNA	17361019\|2126653
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of TOX mRNA	28962523
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of TOX mRNA	26033743
D004237	Diuron	Diuron results in increased expression of TOX mRNA	21551480
C118739	entinostat	entinostat results in increased expression of TOX mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TOX mRNA	22079256
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TOX mRNA	20938992
D008558	Melphalan	Melphalan results in decreased expression of TOX mRNA	22363485
C042720	mercuric bromide	mercuric bromide results in increased expression of TOX mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TOX mRNA	20938992
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of TOX mRNA	26011545
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of TOX mRNA	29191790
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of TOX mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TOX mRNA"	25554681
C029938	nickel sulfate	nickel sulfate results in decreased expression of TOX mRNA	16780908
C029938	nickel sulfate	nickel sulfate results in increased expression of TOX mRNA	22714537
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of TOX mRNA	26272509
C016030	pantogab	pantogab results in increased expression of TOX mRNA	17379144
D010656	Phenylephrine	Phenylephrine results in decreased expression of TOX mRNA	18158353
C006253	pirinixic acid	pirinixic acid results in increased expression of TOX mRNA	18301758\|2081375
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TOX mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of TOX mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of TOX mRNA	22714537
D011374	Progesterone	Progesterone results in decreased expression of TOX mRNA	23012394
D011374	Progesterone	Progesterone results in increased expression of TOX mRNA	23018184
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TOX mRNA	24780913
D012906	Smoke	Smoke results in increased expression of TOX mRNA	21095227
D013739	Testosterone	Testosterone results in decreased expression of TOX mRNA	20844152
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TOX mRNA	24680724\|2892240
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of TOX mRNA	19770486
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of TOX mRNA	28973375
D014212	Tretinoin	Tretinoin results in decreased expression of TOX mRNA	23724009
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of TOX mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of TOX mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of TOX mRNA	23179753\|2438349
D014638	Vanadates	Vanadates results in decreased expression of TOX mRNA	22714537
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of TOX mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0003677	DNA binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	-
GO:0030098	lymphocyte differentiation	-	IEA	-
GO:0032825	positive regulation of natural killer cell differentiation	-	IEA	-
GO:0048535	lymph node development	-	IEA	-
GO:0048541	Peyer's patch development	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22496870	Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers. (2012)	Tessema M	PLoS One
16913548	Smoking and illicit drug use during pregnancy: impact on neonatal outcome. (2006 Jul)	Miles DR	J Reprod Med