Gene: RASSF2

9770
CENP-34|RASFADIN
Ras association domain family member 2
protein-coding
20p13
Ensembl:ENSG00000101265 MIM:609492 Vega:OTTHUMG00000031790 UniprotKB:P50749
NC_000020.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.896e-1 (AD)  7.425e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGF10.92
SLCO1A20.913
ERMN0.911
ZEB20.91
AIF1L0.908
FAM107B0.903
PLA2G160.9
LPAR10.9
BCAS10.898
MBP0.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDH8-0.511
CUX2-0.504
HCN4-0.48
CDH22-0.469
ASB2-0.469
KCNK3-0.467
IGSF3-0.466
FFAR4-0.465
TPBG-0.464
TCERG1L-0.457

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of RASSF2 mRNA19933214
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of RASSF2 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RASSF2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of RASSF2 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RASSF2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of RASSF2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RASSF2 mRNA22100608
C015001arsenitearsenite results in decreased expression of RASSF2 mRNA18929588
D001554BenzeneBenzene results in increased expression of RASSF2 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RASSF2 mRNA alternative form25690898
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of RASSF2 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of RASSF2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of RASSF2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of RASSF2 mRNA12075121
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RASSF2 gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of RASSF2 mRNA19549813
D003474CurcuminCurcumin results in increased expression of RASSF2 mRNA17198877
D016572CyclosporineCyclosporine results in decreased expression of RASSF2 mRNA27989131
D003561CytarabineCytarabine results in increased expression of RASSF2 mRNA21198554
D000069439DasatinibDasatinib results in increased expression of RASSF2 mRNA20579391
C014347decitabinedecitabine affects the expression of RASSF2 mRNA17013896
D004391DustDust results in increased expression of RASSF2 mRNA17805423
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RASSF2 mRNA12075121
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RASSF2 gene20938992
D019833GenisteinGenistein results in increased expression of RASSF2 mRNA12075121
C492448ICG 001ICG 001 results in decreased expression of RASSF2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RASSF2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RASSF2 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RASSF2 mRNA27432991
D007649KetamineKetamine results in decreased expression of RASSF2 mRNA20080153
C045463leflunomideleflunomide results in increased expression of RASSF2 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RASSF2 mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RASSF2 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RASSF2 mRNA"20188158
D009532NickelNickel results in increased expression of RASSF2 mRNA25583101
C570897NSC668394NSC668394 results in increased expression of RASSF2 mRNA27137931
C046012pentanalpentanal results in increased expression of RASSF2 mRNA26079696
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of RASSF2 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of RASSF2 mRNA17950772
D010936Plant ExtractsPlant Extracts results in increased expression of RASSF2 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of RASSF2 mRNA16293270
C005556propionaldehydepropionaldehyde results in increased expression of RASSF2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of RASSF2 mRNA24780913
D015474IsotretinoinIsotretinoin results in increased expression of RASSF2 mRNA20436886
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RASSF2 mRNA19073995
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RASSF2 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RASSF2 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RASSF2 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RASSF2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of RASSF2 promoter25214829
D014212TretinoinTretinoin results in decreased expression of RASSF2 mRNA23724009
D014212TretinoinTretinoin results in increased expression of RASSF2 mRNA23830798
D014212TretinoinTretinoin results in decreased expression of RASSF2 mRNA16788091
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RASSF2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of RASSF2 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of RASSF2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of RASSF2 mRNA17569031
D014520UrethaneUrethane results in decreased expression of RASSF2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of RASSF2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of RASSF2 mRNA19101580|2493525
D014635Valproic AcidValproic Acid results in increased methylation of RASSF2 gene29154799
D014638VanadatesVanadates results in decreased expression of RASSF2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RASSF2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IGI19962960  
GO:0005515protein binding-IPI12732644  19525978  20562859  20920251  23386615  23455922  
23455924  24255178  24366813  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IEA-  
GO:0001503ossification-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0007049cell cycle-IEA-  
GO:0031954positive regulation of protein autophosphorylation-IDA19962960  
GO:0033137negative regulation of peptidyl-serine phosphorylation-IDA19962960  
GO:0038168epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade-IEA-  
GO:0043065positive regulation of apoptotic process-IDA19962960  
GO:0045667regulation of osteoblast differentiation-IEA-  
GO:0045670regulation of osteoclast differentiation-IEA-  
GO:0045860positive regulation of protein kinase activity-IDA19962960  
GO:0046330positive regulation of JNK cascade-IDA19962960  
GO:0046849bone remodeling-IEA-  
GO:0048872homeostasis of number of cells-IEA-  
GO:0050821protein stabilization-IMP19525978  
GO:1901223negative regulation of NIK/NF-kappaB signaling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IDA20813266  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005634nucleus-IDA19525978  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA19525978  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0032991protein-containing complex-IDA19962960  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20887155Gene expression profiling of peripheral blood leukocytes identifies potential novel biomarkers of chronic obstructive pulmonary disease in current and former smokers. (2010 Dec)Edmiston JSBiomarkers
25214829Effect of cigarette smoke condensate on gene promoter methylation in human lung cells. (2014)Lyn-Cook LTob Induc Dis