Gene: RAPGEF5

9771
GFR|MR-GEF|REPAC
Rap guanine nucleotide exchange factor 5
protein-coding
7p15.3
Ensembl:ENSG00000136237 MIM:609527 Vega:OTTHUMG00000152525 UniprotKB:Q92565
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.636e-1 (AD)  2.819e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17707505chr7:22118446 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANK30.937
MTMR20.927
YPEL20.922
BACE10.92
RPS6KC10.919
TRAPPC100.918
MFSD60.916
PEX5L0.914
PTPRD0.914
PRUNE20.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.445
OR4F5-0.429
MAPKAPK3-0.418
RNF135-0.416
LRAT-0.414
EYA2-0.412
AQP5-0.41
PLA2G5-0.401
PON3-0.398
EVC2-0.397

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of RAPGEF5 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RAPGEF5 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RAPGEF5 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RAPGEF5 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of RAPGEF5 mRNA26705709
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of RAPGEF5 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RAPGEF5 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAPGEF5 mRNA21964900|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAPGEF5 mRNA21839799
C006780bisphenol Abisphenol A results in increased expression of RAPGEF5 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of RAPGEF5 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of RAPGEF5 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of RAPGEF5 mRNA25979313
D002737ChloropreneChloroprene results in increased expression of RAPGEF5 mRNA23125180
D002737ChloropreneChloroprene results in increased expression of RAPGEF5 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RAPGEF5 gene20938992
D002922CiguatoxinsCiguatoxins affects the expression of RAPGEF5 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of RAPGEF5 mRNA23811191
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of RAPGEF5 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of RAPGEF5 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of RAPGEF5 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of RAPGEF5 mRNA27989131
D016572CyclosporineCyclosporine results in increased methylation of RAPGEF5 promoter27989131
D004041Dietary FatsDietary Fats results in increased expression of RAPGEF5 mRNA19030233
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RAPGEF5 mRNA24535843
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RAPGEF5 gene20938992
C039281furanfuran results in increased expression of RAPGEF5 mRNA26194646
D019833GenisteinGenistein results in decreased expression of RAPGEF5 protein24552547
D017313FenretinideFenretinide results in increased expression of RAPGEF5 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of RAPGEF5 mRNA26191083
C045463leflunomideleflunomide results in increased expression of RAPGEF5 mRNA28988120
D008694MethamphetamineRAPGEF5 gene SNP affects the susceptibility to Methamphetamine18316681
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RAPGEF5 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RAPGEF5 mRNA"26251327
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of RAPGEF5 promoter18448484
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RAPGEF5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RAPGEF5 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of RAPGEF5 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of RAPGEF5 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RAPGEF5 mRNA25729387
D017239PaclitaxelPaclitaxel results in increased expression of RAPGEF5 protein15907983
C016030pantogabpantogab results in increased expression of RAPGEF5 mRNA17379144
C006253pirinixic acidpirinixic acid results in increased expression of RAPGEF5 mRNA18301758|2381119
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of RAPGEF5 promoter18448484
C017947sodium arsenitesodium arsenite affects the methylation of RAPGEF5 gene28589171
D053260SootSoot results in increased expression of RAPGEF5 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RAPGEF5 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAPGEF5 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of RAPGEF5 mRNA25975270
D013752TetracyclineTetracycline results in increased expression of RAPGEF5 mRNA16917069
D013849ThimerosalThimerosal results in decreased expression of RAPGEF5 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of RAPGEF5 mRNA23411599
C009495titanium dioxidetitanium dioxide affects the expression of RAPGEF5 mRNA17656681
C009495titanium dioxidetitanium dioxide results in decreased expression of RAPGEF5 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of RAPGEF5 mRNA23409001
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RAPGEF5 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of RAPGEF5 mRNA26705709
D014635Valproic AcidValproic Acid affects the expression of RAPGEF5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of RAPGEF5 mRNA23179753|2519280
C025643vinclozolinvinclozolin results in increased expression of RAPGEF5 mRNA23034163
C111237vorinostatvorinostat results in increased expression of RAPGEF5 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS10934204  
GO:0017034Rap guanyl-nucleotide exchange factor activity-IDA10486569  
GO:0030742GTP-dependent protein binding-IPI10934204  
GO ID GO Term Qualifier Evidence PubMed
GO:0007264small GTPase mediated signal transduction-NAS10486569  
GO:0007399nervous system development-NAS10486569  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10486569  
GO:0005654nucleoplasm-IDA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal