Gene: TBC1D5

9779
-
TBC1 domain family member 5
protein-coding
3p24.3
Ensembl:ENSG00000131374 MIM:615740 Vega:OTTHUMG00000155488 UniprotKB:Q92609
NC_000003.12
PubMed|SNP Mapped
6   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.916e-1 (AD)  3.051e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7627732chr3:17743326 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4908967chr3:17733452 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11128838chr3:17655876 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs9823767chr3:17574245 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7647905chr3:17391891 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1374197chr3:17353123 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07654588chr3:17782211TBC1D53.600e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMOD20.903
KIAA11090.901
ASH1L0.901
NNT0.898
SMARCC20.895
KIDINS2200.892
NF10.889
TNPO20.884
PRRC2B0.883
CLCN30.883

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.643
OR4F29-0.615
PRRX2-0.368
NANOGNB-0.329
SPOCD1-0.319
SFN-0.318
PDZK1IP1-0.313
TFPI2-0.308
C9orf135-0.305
CSAG1-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TBC1D5 mRNA"19114083
C0112692,5-hexanedione"2,5-hexanedione results in increased expression of TBC1D5 mRNA"22952946
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of TBC1D5 mRNA21983209
D000082AcetaminophenAcetaminophen results in decreased expression of TBC1D5 mRNA21420995
D020106AcrylamideAcrylamide results in increased expression of TBC1D5 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TBC1D5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TBC1D5 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of TBC1D5 mRNA21757418
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBC1D5 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBC1D5 mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TBC1D5 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBC1D5 mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of TBC1D5 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TBC1D5 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D5 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TBC1D5 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TBC1D5 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of TBC1D5 mRNA25979313
C006698carbendazimcarbendazim results in decreased expression of TBC1D5 mRNA27466211
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBC1D5 gene20938992
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D5 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of TBC1D5 mRNA27594783
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TBC1D5 protein23301498
D000431EthanolEthanol results in increased expression of TBC1D5 mRNA28986285
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBC1D5 gene20938992
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D5 mRNA28628672
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TBC1D5 mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TBC1D5 gene20938992
C025589ochratoxin Aochratoxin A results in increased methylation of TBC1D5 gene26431795
C059514resveratrolresveratrol results in decreased expression of TBC1D5 mRNA25888808
D012822Silicon DioxideSilicon Dioxide results in decreased expression of TBC1D5 mRNA25351596
C009277sodium arsenatesodium arsenate results in increased expression of TBC1D5 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of TBC1D5 protein21925251
C016104sodium bichromatesodium bichromate results in decreased expression of TBC1D5 mRNA17685462
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TBC1D5 mRNA21641980
C061133tamibarotenetamibarotene results in decreased expression of TBC1D5 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBC1D5 mRNA21570461
D014212TretinoinTretinoin results in decreased expression of TBC1D5 mRNA15498508
D014635Valproic AcidValproic Acid affects the expression of TBC1D5 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TBC1D5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005515protein binding-IPI16189514  16713569  20923837  22354992  24603492  27107014  
27385586  
GO:0017137Rab GTPase binding-IBA21873635  
GO:0035612AP-2 adaptor complex binding-IDA24603492  
GO:1905394retromer complex binding-IMP27385586  
GO ID GO Term Qualifier Evidence PubMed
GO:0002092positive regulation of receptor internalization-IMP22354992  
GO:0006886intracellular protein transport-IBA21873635  
GO:0006914autophagy-IDA22354992  
GO:0016236macroautophagy-IMP24603492  
GO:0042147retrograde transport, endosome to Golgi-IMP22354992  
GO:0042594response to starvation-IDA22354992  
GO:0090630activation of GTPase activity-IBA21873635  
GO:1902017regulation of cilium assemblyNOTIMP17646400  
GO ID GO Term Qualifier Evidence PubMed
GO:0005776autophagosome-IDA22354992  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IEA-  
GO:0010008endosome membrane-IDA20923837  
GO:0030122AP-2 adaptor complexcolocalizes_withIDA24603492  
GO:0030904retromer complex-IDA20923837  
GO:0030904retromer complexcolocalizes_withIDA19531583  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:1990316Atg1/ULK1 kinase complexcolocalizes_withIDA24603492  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25589837Proteomic differences with and without ozone-exposure in a smoking-induced emphysema lung model. (2015 Jan)Uh STKorean J Intern Med