Gene: CDA

978
CDD
cytidine deaminase
protein-coding
1p36.12
Ensembl:ENSG00000158825 MIM:123920 Vega:OTTHUMG00000002845 UniprotKB:P32320
NC_000001.11
PubMed
0   ANCO-SNPs
CD|ND|AD
4   
6.470e-1 (AD)  3.307e-1 (ND)   (Frontal_Cortex)
5.171e-1 (AD)  3.781e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC52A30.768
PKN30.757
GGT50.754
MECOM0.747
FXYD50.746
FGR0.744
ACSL50.742
ACVRL10.742
PERP0.74
NAALADL10.738

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VWC2-0.61
MARCH4-0.602
GAD2-0.6
SLC32A1-0.594
TAC1-0.577
CRH-0.575
ABCC12-0.572
DLX1-0.569
SVOP-0.568
NEUROD6-0.567

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB031851-Beta-Ribofuranosyl-1,3-DiazepinoneSmall MoleculeExperimentalTarget
DB00441GemcitabineSmall Molecule95058-81-4ApprovedEnzyme
DB00928AzacitidineSmall Molecule320-67-2Approved|InvestigationalEnzyme
DB00987CytarabineSmall Molecule147-94-4Approved|InvestigationalEnzyme
DB01101CapecitabineSmall Molecule154361-50-9Approved|InvestigationalEnzyme
DB031851-Beta-Ribofuranosyl-1,3-DiazepinoneSmall MoleculeExperimentalEnzyme
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CDA mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDA mRNA"25614096
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of CDA mRNA"20713471
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDA mRNA"27188386
C4182085'-deoxy-5-fluorocytidineCDA protein results in increased metabolism of 5'-deoxy-5-fluorocytidine18077151
C0077455-fluorocytidineCDA protein results in increased metabolism of 5-fluorocytidine21804305
C0077455-fluorocytidineCDA protein results in increased metabolism of 5-fluorocytidine21804305
C0077455-fluorocytidineCDA protein results in increased metabolism of 5-fluorocytidine21804305
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDA mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CDA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDA mRNA27153756
D000638AmiodaroneAmiodarone results in increased expression of CDA mRNA24535564
C547126AZM551248AZM551248 results in increased expression of CDA mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of CDA mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDA mRNA19770486
D004958Estradiol[Progesterone co-treated with Estradiol] affects the expression of CDA mRNA17404688
C006780bisphenol Abisphenol A affects the expression of CDA mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CDA mRNA18804290
D002104CadmiumCadmium results in increased expression of CDA mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CDA mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDA mRNA24643881
D002699ChlorambucilCDA protein results in decreased susceptibility to Chlorambucil10830723
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CDA mRNA18804290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDA mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CDA mRNA28472532
D019327Copper SulfateCopper Sulfate results in increased expression of CDA mRNA19549813
C551994crizotinibcrizotinib results in decreased expression of CDA protein22973962
C551994crizotinib[crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to gemcitabine22973962
D016572CyclosporineCyclosporine affects the expression of CDA mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of CDA mRNA25562108
C014347decitabineCDA protein results in increased degradation of decitabine17616700
D003907DexamethasoneDexamethasone results in increased activity of CDA protein6882797
C074608diazepinone ribosidediazepinone riboside binds to and results in decreased activity of CDA protein15689149
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CDA mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CDA mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CDA mRNA28085963
D002117CalcitriolCalcitriol results in increased expression of CDA mRNA16002434
C118739entinostatentinostat results in increased expression of CDA mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDA mRNA"27188386
C082360fipronilfipronil results in increased expression of CDA mRNA23962444
D005472Fluorouracil[CYP2B1 co-treated with CDA] results in increased susceptibility to Fluorouracil10811482
D005472Fluorouracil[CYP2B1 co-treated with CDA] results in increased susceptibility to [Ifosfamide co-treated with Fluorouracil]10811482
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDA mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of CDA mRNA27664576
C039281furanfuran results in increased expression of CDA mRNA25539665
C546771gardiquimodgardiquimod results in decreased expression of CDA mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CDA mRNA]28003376
C056507gemcitabineCDA protein affects the susceptibility to gemcitabine18728667
C056507gemcitabineCDA protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]18728667
C056507gemcitabineCDA protein affects the susceptibility to [gemcitabine co-treated with oxaliplatin]18728667
C056507gemcitabine[crizotinib results in decreased expression of CDA protein] which results in increased susceptibility to gemcitabine22973962
C010974glyphosateglyphosate results in increased expression of CDA mRNA25636363
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA19695318
D017313FenretinideFenretinide results in increased expression of CDA mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CDA mRNA20044591
D007069Ifosfamide[CYP2B1 co-treated with CDA] results in increased susceptibility to Ifosfamide10811482
D007069Ifosfamide[CYP2B1 co-treated with CDA] results in increased susceptibility to [Ifosfamide co-treated with Fluorouracil]10811482
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDA mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CDA mRNA27392435
C544151jinfukangjinfukang results in increased expression of CDA mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDA mRNA24796395
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CDA mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CDA mRNA26378955
D008558MelphalanCDA protein results in decreased susceptibility to Melphalan10830723
D008713MethimazoleMethimazole results in increased expression of CDA mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDA mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CDA mRNA20713471
D016685MitomycinCDA protein affects the susceptibility to [gemcitabine co-treated with Mitomycin]18728667
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CDA mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CDA mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CDA mRNA"25554681|2562005
C030110oxaliplatinCDA protein affects the susceptibility to [gemcitabine co-treated with oxaliplatin]18728667
D017239PaclitaxelCDA protein affects the susceptibility to Paclitaxel18728667
D010634PhenobarbitalPhenobarbital results in decreased expression of CDA mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CDA mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDA mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CDA mRNA17426115|1830175
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA19695318
D011374Progesterone[Progesterone co-treated with Estradiol] affects the expression of CDA mRNA17404688
D011441PropylthiouracilPropylthiouracil results in decreased expression of CDA mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of CDA mRNA22504374
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CDA mRNA]28003376
D011794QuercetinQuercetin results in increased expression of CDA mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of CDA mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CDA mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of CDA mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CDA mRNA23221170
D012834SilverSilver results in increased expression of CDA mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of CDA mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of CDA mRNA22714537
D053260SootSoot results in increased expression of CDA mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CDA mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CDA mRNA26378955
C016766sulforafansulforafan results in increased expression of CDA mRNA26833863
D013629TamoxifenTamoxifen affects the expression of CDA mRNA20937368
D013629TamoxifenTamoxifen results in decreased expression of CDA mRNA25123088
D005641TegafurCDA gene polymorphism affects the susceptibility to Tegafur18537153
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CDA mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDA mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDA mRNA21354282|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDA mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDA mRNA25613284
D013767TetrahydrouridineTetrahydrouridine results in decreased activity of CDA protein21804305
D013767TetrahydrouridineTetrahydrouridine results in decreased activity of CDA protein21804305
D013767TetrahydrouridineTetrahydrouridine results in decreased activity of CDA protein21804305
C009495titanium dioxidetitanium dioxide results in increased expression of CDA mRNA27760801
C050414tripterinetripterine results in increased expression of CDA mRNA27374097
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CDA mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDA mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CDA mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of CDA mRNA24535564
C029297vinylidene chloridevinylidene chloride results in decreased expression of CDA mRNA26682919
D002762CholecalciferolCholecalciferol results in increased expression of CDA mRNA18537153
D019287Zinc SulfateZinc Sulfate results in increased expression of CDA mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001882nucleoside binding-IDA15689149  
GO:0004126cytidine deaminase activity-EXP7923172  
GO:0004126cytidine deaminase activity-IBA21873635  
GO:0004126cytidine deaminase activity-IDA7923172  9596658  
GO:0005515protein binding-IPI25416956  25910212  
GO:0008270zinc ion binding-IBA21873635  
GO:0008270zinc ion binding-IDA15689149  
GO:0008270zinc ion binding-TAS9596658  
GO:0042803protein homodimerization activity-IDA15689149  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-NAS9596658  
GO:0008655pyrimidine-containing compound salvage-NAS9596658  
GO:0009972cytidine deamination-IBA21873635  
GO:0009972cytidine deamination-IDA9596658  
GO:0019858cytosine metabolic process-TAS7923172  
GO:0030308negative regulation of cell growth-IDA9596658  
GO:0043097pyrimidine nucleoside salvage-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045980negative regulation of nucleotide metabolic process-IDA9596658  
GO:0051289protein homotetramerization-IDA9596658  15689149  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS9596658  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-NAS16303324  
GO:0005829cytosol-TAS9596658  
GO:0034774secretory granule lumen-TAS-  
GO:1904724tertiary granule lumen-TAS-  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa00240Pyrimidine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-73614Pyrimidine salvageTAS
R-HSA-8956321Nucleotide salvageTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15084902Psychiatric comorbidity in treatment-seeking alcoholics: the role of childhood trauma and perceived parental dysfunction. (2004 Mar)Langeland WAlcohol Clin Exp Res
9038761Limited value of serum holo-transcobalamin II measurements in the differential diagnosis of macrocytosis. (1996 Sep)Wickramasinghe SNJ Clin Pathol
11466158Regional cerebral blood flow in cocaine- versus methamphetamine-dependent patients with a history of alcoholism. (2001 Jun)Alhassoon OMInt J Neuropsychopharmacol
25433492Effectiveness of cladribine therapy in patients with pulmonary Langerhans cell histiocytosis. (2014 Nov 30)Grobost VOrphanet J Rare Dis