Gene: RNF144A

9781
RNF144|UBCE7IP4|hUIP4
ring finger protein 144A
protein-coding
2p25.1
Ensembl:ENSG00000151692 Vega:OTTHUMG00000090353 UniprotKB:P50876
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.444e-1 (AD)  8.525e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19240637chr2:7172297RNF144A3.210e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFASC0.903
UBE4B0.901
EZH10.891
POGZ0.884
CBFA2T20.883
OGT0.877
CALCOCO10.875
ABCC50.875
CEP970.875
SORT10.874

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.541
OR4F29-0.512
TFPI2-0.367
KLRB1-0.355
FOXL1-0.35
GJB2-0.339
S100A14-0.338
PDZK1IP1-0.338
TBX21-0.338
SIX1-0.336

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of RNF144A mRNA"26377693
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of RNF144A mRNA16788091
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to RNF144A protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to RNF144A protein]26598702
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RNF144A mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to RNF144A protein]26598702
C006632arsenic trioxidearsenic trioxide results in increased expression of RNF144A mRNA15761015
D001379AzathioprineAzathioprine results in decreased expression of RNF144A mRNA22623647
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of RNF144A mRNA27858113
D001554BenzeneBenzene results in decreased expression of RNF144A mRNA19162166
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of RNF144A mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of RNF144A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RNF144A mRNA20106945|2163298
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of RNF144A mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RNF144A mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of RNF144A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RNF144A gene28505145
D002737ChloropreneChloroprene results in decreased expression of RNF144A mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of RNF144A mRNA27858113
D016572CyclosporineCyclosporine results in decreased expression of RNF144A mRNA25562108
D003703DemecolcineDemecolcine results in decreased expression of RNF144A mRNA23649840
D002945CisplatinCisplatin results in decreased expression of RNF144A mRNA19561079
D002117CalcitriolCalcitriol results in decreased expression of RNF144A mRNA26485663
D002117CalcitriolCalcitriol results in increased expression of RNF144A mRNA16002434
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of RNF144A mRNA22634610
D017313FenretinideFenretinide results in increased expression of RNF144A mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RNF144A mRNA25613284
C544151jinfukangjinfukang results in increased expression of RNF144A mRNA27392435
C410337K 7174K 7174 results in decreased expression of RNF144A mRNA24086573
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RNF144A mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RNF144A mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RNF144A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RNF144A mRNA"25554681|2562005
D010416PentachlorophenolPentachlorophenol results in increased expression of RNF144A mRNA23892564
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of RNF144A mRNA17097637
C006253pirinixic acidpirinixic acid results in increased expression of RNF144A mRNA21318169|2381119
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of RNF144A mRNA]21318169
D011192Potassium DichromatePotassium Dichromate results in increased expression of RNF144A mRNA23608068
C059514resveratrolresveratrol results in decreased expression of RNF144A mRNA19371625
C017947sodium arsenitesodium arsenite affects the methylation of RNF144A gene28589171
D053260SootSoot results in decreased expression of RNF144A mRNA26551751
D013629TamoxifenTamoxifen results in increased expression of RNF144A mRNA25123088
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of RNF144A mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RNF144A mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RNF144A mRNA26377647|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RNF144A promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RNF144A mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of RNF144A mRNA23557971|2776080
C012589trichostatin Atrichostatin A results in increased expression of RNF144A mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RNF144A mRNA"26179874
D014501UraniumUranium affects the expression of RNF144A mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of RNF144A mRNA15672453
D014635Valproic AcidValproic Acid results in increased expression of RNF144A mRNA24935251|2915479
D014750VincristineVincristine results in decreased expression of RNF144A mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19549727  
GO:0031624ubiquitin conjugating enzyme binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-EXP24979766  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0016567protein ubiquitination-TAS-  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005794Golgi apparatus-IDA10942595  
GO:0005886plasma membrane-IEA-  
GO:0010008endosome membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8852135Protein ubiquitinationTAS
R-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29551738Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus. (2018 Mar 15)Dong JClin Gastroenterol Hepatol