Gene: DHX38

9785
DDX38|PRP16|PRPF16
DEAH-box helicase 38
protein-coding
16q22.2
Ensembl:ENSG00000140829 MIM:605584 Vega:OTTHUMG00000137596 UniprotKB:Q92620
NG_034207.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.807e-1 (AD)  6.163e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs35794819chr16:72096204 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SUPT6H0.933
MCM3AP0.914
DCAF50.899
HDLBP0.897
ASXL10.893
SNRNP2000.892
DHX160.889
YY1AP10.889
NONO0.889
EIF3A0.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.659
OR4F5-0.642
OR4F16-0.251
MTRNR2L6-0.248
TRDN-0.239
MTRNR2L10-0.238
IAPP-0.233
MTRNR2L9-0.232
RSPO1-0.22
HMX2-0.204

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of DHX38 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DHX38 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DHX38 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DHX38 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DHX38 mRNA26001963
D004958EstradiolEstradiol affects the expression of DHX38 mRNA18214933
C006780bisphenol Abisphenol A affects the expression of DHX38 mRNA21786754
C006780bisphenol Abisphenol A results in increased methylation of DHX38 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of DHX38 gene28505145
C006780bisphenol Abisphenol A results in increased expression of DHX38 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DHX38 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DHX38 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DHX38 mRNA18804290
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DHX38 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DHX38 mRNA28628672
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of DHX38 mRNA27776689
C039281furanfuran results in decreased methylation of DHX38 gene22079235
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of DHX38 gene28505145
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of DHX38 mRNA22634610
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of DHX38 mRNA24680724
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DHX38 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DHX38 mRNA28628672
D008748MethylcholanthreneMethylcholanthrene results in increased expression of DHX38 mRNA18804290
D010936Plant ExtractsPlant Extracts results in increased expression of DHX38 mRNA23557933
C059514resveratrolresveratrol results in decreased expression of DHX38 protein18089832
D013629TamoxifenTamoxifen results in decreased expression of DHX38 mRNA15590111
C004648testosterone enanthatetestosterone enanthate affects the expression of DHX38 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DHX38 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of DHX38 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in increased methylation of DHX38 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of DHX38 mRNA19042947
D014520UrethaneUrethane results in increased expression of DHX38 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of DHX38 gene29154799
D014635Valproic AcidValproic Acid affects the expression of DHX38 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DHX38 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0005515protein binding-IPI21044950  22365833  25036637  
GO:0005524ATP binding-IEA-  
GO:0034459ATP-dependent 3'-5' RNA helicase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000398mRNA splicing, via spliceosome-IBA21873635  
GO:0000398mRNA splicing, via spliceosome-IC11991638  
GO:0000398mRNA splicing, via spliceosome-IDA9524131  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006405RNA export from nucleus-TAS-  
GO:0006406mRNA export from nucleus-TAS-  
GO:0031124mRNA 3'-end processing-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IBA21873635  
GO:0005634nucleus-NAS9524131  
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complex-IBA21873635  
GO:0016020membrane-HDA19946888  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-109688Cleavage of Growing Transcript in the Termination Region TAS
R-HSA-159236Transport of Mature mRNA derived from an Intron-Containing TranscriptTAS
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72187mRNA 3'-end processingTAS
R-HSA-72202Transport of Mature Transcript to CytoplasmTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-73856RNA Polymerase II Transcription TerminationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal