Gene: DLGAP5

9787
DLG7|HURP
DLG associated protein 5
protein-coding
14q22.3
Ensembl:ENSG00000126787 MIM:617859 Vega:OTTHUMG00000140310 UniprotKB:Q15398
NC_000014.9
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.520e-1 (AD)  1.169e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23678254chr14:55647471DLGAP52.530e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF20A0.792
MKI670.76
TOP2A0.722
AURKB0.72
RRM20.711
HJURP0.697
MYBL20.666
TROAP0.649
IGF2BP10.624
NDC800.621

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WIF1-0.311
ADRA1D-0.293
ARSF-0.286
CYP1A1-0.284
KREMEN2-0.281
ABCD2-0.279
CRH-0.27
BHLHA15-0.263
ACY3-0.259
PAH-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of DLGAP5 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DLGAP5 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of DLGAP5 mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DLGAP5 mRNA"25614096
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DLGAP5 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DLGAP5 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DLGAP5 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DLGAP5 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DLGAP5 mRNA"25510870
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of DLGAP5 mRNA19191707
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of DLGAP5 mRNA19191707
D000082AcetaminophenAcetaminophen results in decreased expression of DLGAP5 mRNA29067470
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of DLGAP5 mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DLGAP5 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DLGAP5 mRNA23630614
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of DLGAP5 mRNA17639512
D001379AzathioprineAzathioprine results in decreased expression of DLGAP5 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of DLGAP5 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DLGAP5 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DLGAP5 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DLGAP5 mRNA"20018196|2038263
D004958EstradiolEstradiol results in increased expression of DLGAP5 mRNA18310284|1916744
C044887beta-methylcholinebeta-methylcholine affects the expression of DLGAP5 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of DLGAP5 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of DLGAP5 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of DLGAP5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of DLGAP5 mRNA25181051
D000069286Bortezomib[BRCA1 mutant form results in increased susceptibility to Bortezomib] which results in decreased expression of DLGAP5 mRNA25522274
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of DLGAP5 mRNA23410634
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of DLGAP5 mRNA15003993
D002104CadmiumCadmium results in decreased expression of DLGAP5 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride affects the expression of DLGAP5 mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DLGAP5 mRNA25993096
C004656chloroacetaldehydechloroacetaldehyde affects the expression of DLGAP5 mRNA25596134
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DLGAP5 mRNA23650126
C059262cidofovircidofovir results in increased expression of DLGAP5 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of DLGAP5 mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of DLGAP5 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of DLGAP5 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of DLGAP5 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DLGAP5 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of DLGAP5 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of DLGAP5 mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of DLGAP5 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of DLGAP5 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DLGAP5 mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of DLGAP5 mRNA20579391
C014347decitabinedecitabine affects the expression of DLGAP5 mRNA23300844
D003976DiazinonDiazinon affects the expression of DLGAP5 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DLGAP5 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of DLGAP5 mRNA28962523
D002945CisplatinCisplatin affects the expression of DLGAP5 mRNA23300844
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in increased expression of DLGAP5 mRNA]21858171
D002945CisplatinCisplatin results in decreased expression of DLGAP5 mRNA25596134|2759478
C000944dicrotophosdicrotophos results in decreased expression of DLGAP5 mRNA28302478
D004026DieldrinDieldrin affects the expression of DLGAP5 mRNA22546817
D002117CalcitriolCalcitriol results in decreased expression of DLGAP5 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of DLGAP5 mRNA21592394
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of DLGAP5 mRNA17374397
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DLGAP5 mRNA22079256
D005054EugenolEugenol results in decreased expression of DLGAP5 mRNA17374397
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of DLGAP5 mRNA24657277
D005557FormaldehydeFormaldehyde results in decreased expression of DLGAP5 mRNA23649840
C039281furanfuran results in increased expression of DLGAP5 mRNA25539665
D019833GenisteinGenistein affects the expression of DLGAP5 mRNA18847459
D019833GenisteinGenistein results in decreased expression of DLGAP5 mRNA22228119
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DLGAP5 mRNA23410634
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DLGAP5 mRNA25613284
C544151jinfukangjinfukang results in increased expression of DLGAP5 mRNA27392435
D007840LatexLatex analog results in increased expression of DLGAP5 mRNA24768652
C045463leflunomideleflunomide results in decreased expression of DLGAP5 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of DLGAP5 mRNA24136188
D008154LucanthoneLucanthone results in decreased expression of DLGAP5 mRNA21148553
D008627Mercuric ChlorideMercuric Chloride affects the expression of DLGAP5 mRNA20353558
D008687MetforminMetformin results in increased expression of DLGAP5 mRNA25596134
D008694MethamphetamineMethamphetamine results in decreased expression of DLGAP5 mRNA25290377
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of DLGAP5 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of DLGAP5 mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of DLGAP5 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DLGAP5 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of DLGAP5 mRNA24810058
D009151Mustard GasMustard Gas results in decreased expression of DLGAP5 mRNA25102026
C017096n-butoxyethanoln-butoxyethanol results in increased expression of DLGAP5 mRNA19812364
C022838nickel chloridenickel chloride affects the expression of DLGAP5 mRNA22546817
C570897NSC668394NSC668394 results in decreased expression of DLGAP5 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of DLGAP5 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DLGAP5 mRNA25729387
D010081OxazoloneOxazolone results in decreased expression of DLGAP5 mRNA17374397
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of DLGAP5 mRNA25658374
D010126OzoneOzone results in decreased expression of DLGAP5 mRNA24336422
C500026palbociclibpalbociclib results in decreased expression of DLGAP5 mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DLGAP5 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of DLGAP5 mRNA24642059
D010634PhenobarbitalPhenobarbital results in increased expression of DLGAP5 mRNA23091169
D048789PhytoestrogensPhytoestrogens results in increased expression of DLGAP5 mRNA18310284
C006253pirinixic acidpirinixic acid results in increased expression of DLGAP5 mRNA19162173
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in increased expression of DLGAP5 mRNA]21858171
D010894PiroxicamPiroxicam results in increased expression of DLGAP5 mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DLGAP5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DLGAP5 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of DLGAP5 mRNA21795739
C005556propionaldehydepropionaldehyde results in decreased expression of DLGAP5 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of DLGAP5 mRNA24780913
D011748PyrogallolPyrogallol results in increased expression of DLGAP5 mRNA20362636
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of DLGAP5 mRNA17639512
D011794QuercetinQuercetin results in decreased expression of DLGAP5 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of DLGAP5 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DLGAP5 mRNA25895662
C017947sodium arsenitesodium arsenite inhibits the reaction [E2F1 protein binds to DLGAP5 promoter]17998272
C017947sodium arsenitesodium arsenite promotes the reaction [E2F4 protein binds to DLGAP5 promoter]17998272
C017947sodium arsenitesodium arsenite results in decreased expression of DLGAP5 mRNA17998272
D013629TamoxifenTamoxifen results in decreased expression of DLGAP5 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of DLGAP5 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of DLGAP5 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DLGAP5 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DLGAP5 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DLGAP5 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of DLGAP5 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of DLGAP5 mRNA26217789
D019284ThapsigarginThapsigargin results in decreased expression of DLGAP5 mRNA22378314
D019284ThapsigarginThapsigargin results in increased expression of DLGAP5 protein24648495
D013853ThioacetamideThioacetamide results in increased expression of DLGAP5 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DLGAP5 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DLGAP5 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of DLGAP5 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of DLGAP5 gene27618143
C012589trichostatin Atrichostatin A results in decreased expression of DLGAP5 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of DLGAP5 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DLGAP5 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of DLGAP5 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of DLGAP5 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of DLGAP5 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of DLGAP5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DLGAP5 mRNA27188386|2800136
D024483Vitamin K 3Vitamin K 3 affects the expression of DLGAP5 mRNA20044591|2341063
C111237vorinostatvorinostat results in increased expression of DLGAP5 mRNA27188386
D015032ZincZinc deficiency results in increased expression of DLGAP5 mRNA22171008
C088658zoledronic acidzoledronic acid results in decreased expression of DLGAP5 mRNA24714768|2559613

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004721phosphoprotein phosphatase activity-IDA15145941  
GO:0004721phosphoprotein phosphatase activity-ISS-  
GO:0005515protein binding-IPI15145941  15987997  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006470protein dephosphorylation-IEA-  
GO:0007079mitotic chromosome movement towards spindle pole-NAS12527899  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0008283cell proliferation-NAS12527899  
GO:0045842positive regulation of mitotic metaphase/anaphase transition-NAS12527899  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12527899  
GO:0005634nucleus-ISS-  
GO:0005739mitochondrion-IDA-  
GO:0005815microtubule organizing center-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0031616spindle pole centrosome-IDA12527899  
GO:0031616spindle pole centrosome-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionTAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal