Gene: MTSS1

9788
MIM|MIMA|MIMB
MTSS1, I-BAR domain containing
protein-coding
8q24.13
Ensembl:ENSG00000170873 MIM:608486 Vega:OTTHUMG00000048189 UniprotKB:O43312
NC_000008.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.329e-1 (AD)  7.261e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24838345chr8:125737353MTSS11.700e-12Smoking27651444
cg24838345chr8:125737353MTSS12.020e-8Tobacco smoking28225026
cg24838345chr8:125737353MTSS15.980e-11Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DYNC1I20.828
SLC39A60.821
SCARB20.817
APBB20.816
SF3B10.811
ITCH0.809
ACER30.806
SNX10.802
HNRNPA30.802
CTTNBP20.801

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.676
OR4F29-0.65
NANOGNB-0.178
AHSP-0.158
LBP-0.154
PLA2G5-0.152
LCE3B-0.147
MBD3L3-0.14
HOXD4-0.139
MT1B-0.137

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of MTSS1 mRNA"26377693
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of MTSS1 mRNA"22101062
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of MTSS1 mRNA"19095052
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of MTSS1 mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MTSS1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTSS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTSS1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of MTSS1 mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of MTSS1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTSS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTSS1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MTSS1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of MTSS1 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of MTSS1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MTSS1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MTSS1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MTSS1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MTSS1 mRNA24449571
D001194AsbestosAsbestos results in decreased expression of MTSS1 mRNA21563230
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MTSS1 mRNA20064835|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MTSS1 mRNA19770486|2156981
D004958EstradiolEstradiol affects the expression of MTSS1 mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of MTSS1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of MTSS1 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of MTSS1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of MTSS1 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of MTSS1 protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MTSS1 mRNA22079614
D002065BuspironeBuspirone results in increased expression of MTSS1 mRNA24136188
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of MTSS1 protein"23026733
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MTSS1 mRNA23650126
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTSS1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of MTSS1 mRNA26272509
D002737ChloropreneChloroprene results in decreased expression of MTSS1 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of MTSS1 mRNA17382205
D002922CiguatoxinsCiguatoxins affects the expression of MTSS1 mRNA18353800
D002994ClofibrateClofibrate affects the expression of MTSS1 mRNA16081524
D019327Copper SulfateCopper Sulfate results in decreased expression of MTSS1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of MTSS1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of MTSS1 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of MTSS1 mRNA19770486
C014347decitabinedecitabine affects the methylation of MTSS1 promoter16921485
C014347decitabine[decitabine affects the methylation of MTSS1 promoter] which affects the expression of MTSS1 mRNA16921485|1692148
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of MTSS1 mRNA]21095227
C014347decitabinedecitabine results in increased expression of MTSS1 mRNA16367923
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MTSS1 mRNA]27941970
D004008DiclofenacDiclofenac results in increased expression of MTSS1 mRNA26934552
D002117CalcitriolCalcitriol results in increased expression of MTSS1 mRNA16002434
C024629dimethyl phthalatedimethyl phthalate affects the expression of MTSS1 mRNA26924002
D004317DoxorubicinMTSS1 mRNA affects the susceptibility to Doxorubicin16243817
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MTSS1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MTSS1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTSS1 mRNA17942748
C069837fullerene C60fullerene C60 results in decreased expression of MTSS1 mRNA19167457
C039281furanfuran results in increased expression of MTSS1 mRNA26194646
D017313FenretinideFenretinide results in increased expression of MTSS1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTSS1 mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of MTSS1 mRNA20003209
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MTSS1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MTSS1 mRNA26582142
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MTSS1 mRNA21641980
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of MTSS1 mRNA20843944
C042720mercuric bromidemercuric bromide results in decreased expression of MTSS1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MTSS1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MTSS1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MTSS1 mRNA28001369
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of MTSS1 protein"23026733
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MTSS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MTSS1 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of MTSS1 mRNA19812364
C051752nefazodonenefazodone results in increased expression of MTSS1 mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of MTSS1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of MTSS1 mRNA16780908|1738220
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of MTSS1 mRNA19074003
C507134ON 01910ON 01910 results in increased expression of MTSS1 mRNA22351695
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MTSS1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of MTSS1 mRNA26516004
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of MTSS1 mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of MTSS1 mRNA23892564
D010634PhenobarbitalPhenobarbital results in decreased expression of MTSS1 mRNA19270015|2309116
D010795Phthalic AcidsPhthalic Acids results in increased expression of MTSS1 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of MTSS1 mRNA20813756|2381119
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MTSS1 mRNA17382205
C045950propiconazolepropiconazole results in decreased expression of MTSS1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of MTSS1 mRNA24780913
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of MTSS1 mRNA"21152443
D011794QuercetinQuercetin results in decreased expression of MTSS1 mRNA21632981
C089730rosiglitazonerosiglitazone results in decreased expression of MTSS1 mRNA25572481
C410733scriptaidscriptaid affects the expression of MTSS1 mRNA18813790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MTSS1 mRNA25895662
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of MTSS1 mRNA]21095227
D012906SmokeSmoke results in decreased expression of MTSS1 mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of MTSS1 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of MTSS1 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of MTSS1 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of MTSS1 mRNA24431212
D012999SomanSoman results in decreased expression of MTSS1 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MTSS1 mRNA21641980
D013629TamoxifenTamoxifen affects the expression of MTSS1 mRNA17555576
C112765tanespimycintanespimycin results in increased expression of MTSS1 mRNA19514085
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of MTSS1 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTSS1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MTSS1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MTSS1 mRNA18691609|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MTSS1 mRNA25270620|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MTSS1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTSS1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of MTSS1 mRNA23557971|2776080
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MTSS1 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of MTSS1 mRNA24935251|2854253
C057693troglitazonetroglitazone results in decreased expression of MTSS1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased methylation of MTSS1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MTSS1 mRNA24935251
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MTSS1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003785actin monomer binding-IDA12570871  
GO:0005102signaling receptor binding-IPI12570871  
GO:0005515protein binding-IPI15383276  15688017  
GO:0042802identical protein binding-IPI14752106  
GO ID GO Term Qualifier Evidence PubMed
GO:0007009plasma membrane organization-IEA-  
GO:0007155cell adhesion-NAS12570871  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-TAS12570871  
GO:0030035microspike assembly-NAS12570871  
GO:0030036actin cytoskeleton organization-TAS12082544  
GO:0050680negative regulation of epithelial cell proliferation-ISS-  
GO:0061333renal tubule morphogenesis-ISS-  
GO:0071498cellular response to fluid shear stress-ISS-  
GO:0072102glomerulus morphogenesis-ISS-  
GO:0072160nephron tubule epithelial cell differentiation-ISS-  
GO:2001013epithelial cell proliferation involved in renal tubule morphogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-NAS12570871  
GO:0005737cytoplasm-TAS12570871  
GO:0015629actin cytoskeleton-IDA12570871  
GO:0030139endocytic vesicle-TAS12570871  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17409975Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers. (2006 Nov)Lam DCJ Thorac Oncol
26829059Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study. (2015)Sayols-Baixeras SEpigenetics