Gene: MAML1

9794
Mam-1|Mam1
mastermind like transcriptional coactivator 1
protein-coding
5q35.3
Ensembl:ENSG00000161021 MIM:605424 Vega:OTTHUMG00000163237 UniprotKB:Q92585
NG_046922.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.801e-1 (AD)  7.753e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHF120.927
ZFYVE260.914
BAZ2A0.902
LRCH30.897
TTC170.893
NUP1880.891
NEK90.884
CASP20.881
NUP2140.876
PHF80.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.544
OR4F29-0.508
KLRC2-0.309
PAGE4-0.258
C22orf42-0.212
CRH-0.212
AVP-0.209
HMX2-0.208
FOXB1-0.208
IAPP-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of MAML1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAML1 gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of MAML1 mRNA20458559
C015001arsenitearsenite results in decreased expression of MAML124473123
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MAML1 mRNA"17331233
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAML1 mRNA22228805
C006780bisphenol Abisphenol A results in decreased methylation of MAML1 gene28505145
C006780bisphenol Abisphenol A results in increased methylation of MAML1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of MAML1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of MAML1 promoter22457795
D002273CarcinogensCarcinogens results in decreased expression of MAML1 mRNA22269147
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MAML1 gene20938992
D016572CyclosporineCyclosporine results in decreased expression of MAML1 mRNA25562108|2798913
C000944dicrotophosdicrotophos results in increased expression of MAML1 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MAML1 mRNA23550701
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MAML1 gene20938992
D005839GentamicinsGentamicins results in increased expression of MAML1 mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of MAML1 mRNA22634610
D007213IndomethacinIndomethacin results in decreased expression of MAML1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAML1 mRNA25613284
D007854LeadLead affects the expression of MAML1 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MAML1 gene20938992
C000621033napabucasinnapabucasin results in decreased expression of MAML1 mRNA25605917
C016030pantogabpantogab results in decreased expression of MAML1 mRNA17379144
C046012pentanalpentanal results in decreased expression of MAML1 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of MAML1 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAML1 mRNA19710929
C045950propiconazolepropiconazole results in decreased expression of MAML1 mRNA21278054
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MAML1 mRNA23221170
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAML1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MAML1 mRNA25613284
C057693troglitazonetroglitazone results in decreased expression of MAML1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of MAML1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MAML1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IBA21873635  
GO:0003713transcription coactivator activity-IDA11101851  
GO:0005515protein binding-IPI11101851  11390662  16510869  16530044  18427106  19907488  
20972443  22325781  23022380  
GO:0019901protein kinase binding-IPI15546612  
GO:0042605peptide antigen binding-IPI17317671  
GO ID GO Term Qualifier Evidence PubMed
GO:0003162atrioventricular node development-ISS-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006468protein phosphorylation-IDA16510869  
GO:0007219Notch signaling pathway-IDA11101851  
GO:0007219Notch signaling pathway-TAS-  
GO:0007221positive regulation of transcription of Notch receptor target-IBA21873635  
GO:0007221positive regulation of transcription of Notch receptor target-TAS-  
GO:0010831positive regulation of myotube differentiation-IGI16510869  
GO:0045445myoblast differentiation-IEA-  
GO:0045747positive regulation of Notch signaling pathway-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA11101851  16510869  
GO:0060928atrioventricular node cell development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002193MAML1-RBP-Jkappa- ICN1 complex-IDA16510869  
GO:0005634nucleus-IDA9874765  11101851  16510869  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0016607nuclear speck-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1912408Pre-NOTCH Transcription and TranslationIEA
R-HSA-1912408Pre-NOTCH Transcription and TranslationTAS
R-HSA-1912422Pre-NOTCH Expression and ProcessingIEA
R-HSA-1912422Pre-NOTCH Expression and ProcessingTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980143Signaling by NOTCH1TAS
R-HSA-1980145Signaling by NOTCH2TAS
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionIEA
R-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionTAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2197563NOTCH2 intracellular domain regulates transcriptionTAS
R-HSA-2197563NOTCH2 intracellular domain regulates transcriptionIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-350054Notch-HLH transcription pathwayTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3IEA
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8941856RUNX3 regulates NOTCH signalingIEA
R-HSA-8941856RUNX3 regulates NOTCH signalingTAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionTAS
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27814717Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations. (2016 Nov 5)Busch RRespir Res