Gene: ACYP2

98
ACYM|ACYP
acylphosphatase 2
protein-coding
2p16.2
Ensembl:ENSG00000170634 MIM:102595 Vega:OTTHUMG00000129287 UniprotKB:P14621
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.407e-1 (AD)  7.372e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FUNDC20.885
NDUFB40.877
DPY300.872
GABARAPL20.871
NDUFC10.87
MPC10.866
PARK70.864
NDUFA20.861
COA50.86
COA30.859

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.683
OR4F29-0.661
PZP-0.423
SIX1-0.407
DPPA4-0.405
FER1L6-0.404
C2orf83-0.398
IL2RB-0.394
CLEC12A-0.393
GADL1-0.392

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01942Formic AcidSmall Molecule64-18-6Approved|Experimental|InvestigationalTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of ACYP2 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of ACYP2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACYP2 mRNA19770486
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ACYP2 mRNA16631469
C006632arsenic trioxidearsenic trioxide results in increased expression of ACYP2 mRNA27829220
C015001arsenitearsenite results in increased expression of ACYP2 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in increased expression of ACYP2 mRNA]18929588
D001280AtrazineAtrazine results in increased expression of ACYP2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACYP2 mRNA21632981|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACYP2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ACYP2 mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of ACYP2 mRNA23019147
D004958EstradiolEstradiol results in decreased expression of ACYP2 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of ACYP2 mRNA21932408
C006780bisphenol Abisphenol A affects the expression of ACYP2 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of ACYP2 protein28903499
D007631ChlordeconeACYP2 gene SNP affects the susceptibility to Chlordecone25622337
C018021cobaltous chloridecobaltous chloride results in increased expression of ACYP2 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ACYP2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of ACYP2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ACYP2 mRNA25562108
D003703DemecolcineDemecolcine results in increased expression of ACYP2 mRNA23649840
C051716dichloroacetonitrileACYP2 gene SNP affects the susceptibility to dichloroacetonitrile25622337
D002945CisplatinACYP2 gene polymorphism results in increased susceptibility to Cisplatin25665007
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ACYP2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ACYP2 mRNA27392435
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACYP2 mRNA17942748
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ACYP2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ACYP2 mRNA27392435
C410337K 7174K 7174 results in increased expression of ACYP2 mRNA24086573
C008261lead acetatelead acetate results in decreased expression of ACYP2 mRNA20542052
C004925methylmercuric chloridemethylmercuric chloride affects the expression of ACYP2 protein27012723
C568376MT19c compoundMT19c compound results in increased expression of ACYP2 mRNA21781307
C016096N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine"ACYP2 gene SNP affects the susceptibility to N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine"25622337
D009532NickelNickel results in decreased expression of ACYP2 mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ACYP2 mRNA20971185
C006253pirinixic acidpirinixic acid results in increased expression of ACYP2 mRNA18301758|2081375
D011374ProgesteroneProgesterone results in increased expression of ACYP2 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of ACYP2 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACYP2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACYP2 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ACYP2 mRNA25613284
C057693troglitazonetroglitazone results in increased expression of ACYP2 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of ACYP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ACYP2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of ACYP2 gene29154799
C029297vinylidene chloridevinylidene chloride results in decreased expression of ACYP2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003998acylphosphatase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0042802identical protein binding-IPI16084386  
GO ID GO Term Qualifier Evidence PubMed
GO:0006796phosphate-containing compound metabolic process-TAS8268218  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
hsa00620Pyruvate metabolism
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29228661Interactions between ACYP2 genetic polymorphisms and environment factors with susceptibility to ischemic stroke in a Han Chinese Population. (2017 Nov 17)Cheng QOncotarget