Gene: TOMM20

9804
MAS20|MOM19|TOM20
translocase of outer mitochondrial membrane 20
protein-coding
1q42.3
Ensembl:ENSG00000173726 MIM:601848 Vega:OTTHUMG00000039619 UniprotKB:Q15388
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.563e-1 (AD)  6.834e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4329572chr1:235127607 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PJA20.973
SLU70.971
RAB6A0.97
GDAP10.97
REEP50.967
YWHAB0.967
RUFY30.966
DNM1L0.966
PAFAH1B10.965
RTN40.964

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.653
OR4F29-0.646
EVC2-0.388
WDR38-0.37
MTRNR2L6-0.36
FOXJ1-0.356
CSAG1-0.354
MTRNR2L10-0.347
MTRNR2L9-0.339
RUNX3-0.332

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of TOMM20 mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TOMM20 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TOMM20 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TOMM20 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TOMM20 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of TOMM20 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of TOMM20 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of TOMM20 protein28827156
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TOMM20 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TOMM20 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of TOMM20 mRNA22378314
C006780bisphenol Abisphenol A results in decreased expression of TOMM20 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of TOMM20 gene22576693
C006780bisphenol Abisphenol A results in decreased expression of TOMM20 protein26139607
C006780bisphenol Abisphenol A results in increased expression of TOMM20 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TOMM20 mRNA18804290
D002220CarbamazepineCarbamazepine affects the expression of TOMM20 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of TOMM20 mRNA18804290
C100187chloropicrinchloropicrin results in increased expression of TOMM20 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TOMM20 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TOMM20 mRNA28472532
D002994ClofibrateClofibrate results in increased expression of TOMM20 mRNA12851107
D002995Clofibric AcidClofibric Acid affects the expression of TOMM20 mRNA17602206
D019327Copper SulfateCopper Sulfate results in decreased expression of TOMM20 mRNA21595052
D019327Copper SulfateCopper Sulfate results in decreased expression of TOMM20 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TOMM20 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of TOMM20 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TOMM20 mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TOMM20 mRNA21266533
D004026DieldrinDieldrin results in increased expression of TOMM20 mRNA20584760
D004041Dietary FatsDietary Fats results in decreased expression of TOMM20 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in decreased expression of TOMM20 mRNA]19030233
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOMM20 mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of TOMM20 promoter25374375
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of TOMM20 mRNA27638505
D004317DoxorubicinTOMM20 mRNA results in decreased susceptibility to Doxorubicin16322897
D004656EnalaprilEnalapril results in decreased expression of TOMM20 mRNA18765277
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TOMM20 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TOMM20 mRNA20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TOMM20 mRNA24096037
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TOMM20 mRNA24096037
D005485FlutamideFlutamide results in increased expression of TOMM20 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TOMM20 mRNA20938992
D005839GentamicinsGentamicins results in increased expression of TOMM20 mRNA22061828
D017313FenretinideFenretinide results in increased expression of TOMM20 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of TOMM20 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TOMM20 mRNA25613284
D007657Ketone BodiesKetone Bodies results in increased expression of TOMM20 mRNA16807920
C067713lactacystinlactacystin affects the localization of TOMM20 protein11161710
D019808LosartanLosartan results in decreased expression of TOMM20 mRNA18765277
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TOMM20 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TOMM20 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of TOMM20 mRNA12884408
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TOMM20 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TOMM20 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of TOMM20 mRNA24136188
C012655nimesulidenimesulide results in increased expression of TOMM20 mRNA24136188
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of TOMM20 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of TOMM20 mRNA]"21673326
C016340o,p'-DDT"o,p'-DDT results in increased expression of TOMM20 mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of TOMM20 mRNA"24096037
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TOMM20 mRNA19162173
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TOMM20 mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of TOMM20 promoter25374375
C006253pirinixic acidpirinixic acid results in increased expression of TOMM20 mRNA18445702|2381119
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TOMM20 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TOMM20 mRNA22079256
C045950propiconazolepropiconazole results in increased expression of TOMM20 mRNA21278054
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in decreased expression of TOMM20 mRNA]19030233
C089730rosiglitazonerosiglitazone affects the expression of TOMM20 mRNA22013433
C009277sodium arsenatesodium arsenate results in decreased expression of TOMM20 mRNA23922661
C009277sodium arsenatesodium arsenate results in increased expression of TOMM20 mRNA16882884
D012999SomanSoman results in increased expression of TOMM20 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TOMM20 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TOMM20 mRNA26232522
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TOMM20 mRNA25613284
C066340tolcaponetolcapone binds to TOMM20 protein19783845
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TOMM20 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of TOMM20 mRNA28973697
D014501UraniumUranium affects the expression of TOMM20 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of TOMM20 mRNA15672453
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of TOMM20 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of TOMM20 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TOMM20 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of TOMM20 mRNA17292431|1796380

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14557246  20231292  
GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity-IBA21873635  
GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity-IDA14557246  
GO:0030943mitochondrion targeting sequence binding-IBA21873635  
GO:0051082unfolded protein binding-IDA14557246  
GO ID GO Term Qualifier Evidence PubMed
GO:0006626protein targeting to mitochondrion-IDA14557246  
GO:0014850response to muscle activity-IEA-  
GO:0016031tRNA import into mitochondrion-IBA21873635  
GO:0016579protein deubiquitination-TAS-  
GO:0030150protein import into mitochondrial matrix-IBA21873635  
GO:0070096mitochondrial outer membrane translocase complex assembly-IBA21873635  
GO:1905242response to 3,3',5-triiodo-L-thyronine-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA25327288  
GO:0005741mitochondrial outer membrane-IDA25997101  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005742mitochondrial outer membrane translocase complex-IBA21873635  
GO:0005742mitochondrial outer membrane translocase complex-NAS7498524  
GO:0005742mitochondrial outer membrane translocase complex-TAS14557246  15644312  
GO:0031307integral component of mitochondrial outer membrane-IBA21873635  
GO:0044233ER-mitochondrion membrane contact site-IDA23455425  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1268020Mitochondrial protein importIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-5205647MitophagyTAS
R-HSA-5205685Pink/Parkin Mediated MitophagyTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal