Gene: SPOCK2

9806
testican-2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
protein-coding
10q22.1
Ensembl:ENSG00000107742 MIM:607988 Vega:OTTHUMG00000018430 UniprotKB:Q92563
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.049e-1 (AD)  4.152e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12752647chr10:73849106SPOCK22.010e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC22A170.963
USP110.961
NDRG40.96
GPI0.959
SPTAN10.959
MAPRE30.956
HK10.956
ATP13A20.954
DNAJC50.954
ATP6V0A10.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.708
OR4F29-0.678
TFPI2-0.41
KCNJ15-0.388
RAI14-0.386
MTRNR2L6-0.382
SGMS2-0.378
KLRB1-0.375
IL18RAP-0.37
MTRNR2L9-0.369

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SPOCK2 mRNA19933214
D000082AcetaminophenAcetaminophen results in increased expression of SPOCK2 mRNA29067470
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SPOCK2 mRNA22129741
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SPOCK2 mRNA24449571
D001280AtrazineAtrazine results in increased expression of SPOCK2 mRNA22378314
D001554BenzeneBenzene results in increased expression of SPOCK2 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SPOCK2 mRNA22316170
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SPOCK2 mRNA"26238291
C038328BEP protocolBEP protocol results in increased expression of SPOCK2 mRNA18987330
C452139BIRB 796BIRB 796 results in decreased expression of SPOCK2 mRNA24303162
C006780bisphenol Abisphenol A affects the expression of SPOCK2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SPOCK2 mRNA29097150
C013418bromfenacoumbromfenacoum results in increased expression of SPOCK2 protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SPOCK2 mRNA22079614
D002220CarbamazepineCarbamazepine affects the expression of SPOCK2 mRNA25979313
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SPOCK2 mRNA27188386
D002994ClofibrateClofibrate results in increased expression of SPOCK2 mRNA17585979
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SPOCK2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SPOCK2 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of SPOCK2 mRNA20705681
D002945CisplatinCisplatin results in decreased expression of SPOCK2 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of SPOCK2 mRNA25016146
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SPOCK2 mRNA22129741
D004237DiuronDiuron results in decreased expression of SPOCK2 mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SPOCK2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SPOCK2 mRNA16467188|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SPOCK2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SPOCK2 mRNA17557909
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SPOCK2 mRNA29097150
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SPOCK2 mRNA22129741
D007545IsoproterenolIsoproterenol results in increased expression of SPOCK2 mRNA20003209
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SPOCK2 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SPOCK2 mRNA24810058
D009532NickelNickel results in increased expression of SPOCK2 mRNA24768652|2558310
D009966OrphenadrineOrphenadrine affects the expression of SPOCK2 mRNA23665939
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of SPOCK2 mRNA20705681
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SPOCK2 mRNA22237054
D010705PhosgenePhosgene affects the expression of SPOCK2 mRNA16300373
C005556propionaldehydepropionaldehyde results in increased expression of SPOCK2 mRNA26079696
D012906SmokeSmoke results in decreased expression of SPOCK2 mRNA21095227
D013629TamoxifenTamoxifen affects the expression of SPOCK2 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SPOCK2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPOCK2 mRNA16467188
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SPOCK2 mRNA19933214
C009495titanium dioxidetitanium dioxide results in increased expression of SPOCK2 mRNA23409001
D014635Valproic AcidValproic Acid affects the expression of SPOCK2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of SPOCK2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SPOCK2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SPOCK2 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IDA10386950  
GO:0005518collagen binding-IBA21873635  
GO:0005539glycosaminoglycan binding-IEA-  
GO:0008191metalloendopeptidase inhibitor activity-TAS12810672  
GO:0050840extracellular matrix binding-IBA21873635  
GO:0050840extracellular matrix binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007416synapse assembly-NAS10386950  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0010951negative regulation of endopeptidase activity-TAS12810672  
GO:0019800peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan-IEA-  
GO:0030198extracellular matrix organization-NAS10386950  
GO:0045595regulation of cell differentiation-NAS10386950  
GO:0048856anatomical structure development-IBA21873635  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO:2000147positive regulation of cell motility-TAS12810672  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0031012extracellular matrix-NAS10386950  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22832964Genome-wide meta-analyses of smoking behaviors in African Americans. (2012 May 22)David SPTransl Psychiatry