Gene: GIT2

9815
CAT-2|CAT2|PKL
GIT ArfGAP 2
protein-coding
12q24.11
Ensembl:ENSG00000139436 MIM:608564 Vega:OTTHUMG00000169313 UniprotKB:Q14161
NG_029885.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.415e-1 (AD)  8.154e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs925368chr12:109953174 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TCERG10.931
HKR10.927
GTF3C20.922
CAPRIN20.92
QRICH10.917
WDR190.916
SEC16A0.916
TSC10.913
GGA20.913
ERCC30.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.538
OR4F29-0.494
KLRC2-0.317
LRAT-0.31
TRDN-0.306
MYL3-0.297
S100A1-0.284
ZNF114-0.281
AQP5-0.279
ANXA13-0.279

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GIT2 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GIT2 mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of GIT2 protein26194647
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GIT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GIT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GIT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GIT2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GIT2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GIT2 mRNA19770486
C006632arsenic trioxidearsenic trioxide results in increased expression of GIT2 mRNA15761015
D001280AtrazineAtrazine results in increased expression of GIT2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of GIT2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GIT2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GIT2 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased methylation of GIT2 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of GIT2 mRNA25181051
D002166CamptothecinGIT2 mRNA results in decreased susceptibility to Camptothecin25269479
D002220CarbamazepineCarbamazepine affects the expression of GIT2 mRNA24752500
D019327Copper SulfateCopper Sulfate results in increased expression of GIT2 mRNA19264136
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of GIT2 mRNA]21095227
D004008DiclofenacDiclofenac affects the expression of GIT2 mRNA24752500
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GIT2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GIT2 mRNA17555576|1794274
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GIT2 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of GIT2 mRNA23649840
C039281furanfuran results in increased methylation of GIT2 gene22079235
C492448ICG 001ICG 001 results in increased expression of GIT2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GIT2 mRNA25613284
D007854LeadLead results in increased expression of GIT2 mRNA19921347
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GIT2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GIT2 mRNA"20188158
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GIT2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GIT2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GIT2 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GIT2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GIT2 mRNA22079256
C059514resveratrolresveratrol results in decreased expression of GIT2 protein18089832
C059514resveratrolresveratrol results in increased expression of GIT2 mRNA23419489
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of GIT2 mRNA]21095227
D012999SomanSoman results in decreased expression of GIT2 mRNA19281266
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GIT2 mRNA"18579281
D013629TamoxifenTamoxifen affects the expression of GIT2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GIT2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GIT2 promoter]19654925
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GIT2 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of GIT2 mRNA27188386
C483909torcetrapibtorcetrapib results in increased expression of GIT2 mRNA23228038
C012589trichostatin Atrichostatin A results in decreased expression of GIT2 mRNA24935251
D014303TrinitrotolueneTrinitrotoluene affects the expression of GIT2 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of GIT2 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GIT2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GIT2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GIT2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of GIT2 mRNA19101580

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IEA-  
GO:0005515protein binding-IPI16628223  17353931  21295525  21988832  22728435  26496610  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-TAS10896954  
GO:0043547positive regulation of GTPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA10942595  
GO:0005925focal adhesion-HDA21423176  
KEGG ID KEGG Term
hsa04144Endocytosis
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal