Gene: KEAP1

9817
INrf2|KLHL19
kelch like ECH associated protein 1
protein-coding
19p13.2
Ensembl:ENSG00000079999 MIM:606016 Vega:OTTHUMG00000180579 UniprotKB:Q14145
NC_000019.10
PubMed
ND
22   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.316e-1 (AD)  9.836e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS720.928
PHB0.927
RNF1670.924
YIPF30.923
UBE2L30.921
CUTA0.917
SNX150.916
AIP0.915
THAP40.915
MRPL380.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.788
OR4F29-0.741
IL18RAP-0.351
CEACAM3-0.333
DPPA4-0.331
FOXL1-0.321
CLEC12A-0.319
C2orf83-0.319
KCNJ15-0.319
KLRF1-0.318

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08908Dimethyl fumarateSmall Molecule624-49-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of and affects the localization of KEAP1 protein"27178040
C0506421,2-dihydroxynaphthalene"1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein"25807370
C0506421,2-dihydroxynaphthalene"Glutathione inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein]"25807370
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]"15302862
C1180091,2-epoxy-4-vinylcyclohexane"1,2-epoxy-4-vinylcyclohexane results in decreased expression of KEAP1 mRNA"26117601
C0407561,2-naphthoquinone"1,2-naphthoquinone results in increased metabolism of KEAP1 protein"21384861|2580737
C0407561,2-naphthoquinone"KEAP1 protein affects the susceptibility to 1,2-naphthoquinone"21384861
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of KEAP1 mRNA25596134
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 affects the metabolism of KEAP1 protein18785192
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KEAP1 mRNA"21346803
C0229602-oxindole2-oxindole inhibits the reaction [CUL3 protein binds to KEAP1 protein]22245129
C0229602-oxindole2-oxindole results in decreased activity of KEAP1 protein22245129
C0229602-oxindole[2-oxindole results in decreased activity of KEAP1 protein] which results in decreased ubiquitination of NFE2L2 protein22245129
C5529292-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene"2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased glutathionylation of KEAP1 protein"20800667
C5529292-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene"Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased glutathionylation of KEAP1 protein]"20800667
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]18417180
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]18417180
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone promotes the reaction [KEAP1 protein binds to NFE2L2 protein]18417180
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of KEAP1 protein19033392
C0188552-tert-butylhydroquinoneKEAP1 protein mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]23589329
C0188552-tert-butylhydroquinoneKEAP1 protein mutant form results in decreased susceptibility to 2-tert-butylhydroquinone23589329
C0188552-tert-butylhydroquinoneKEAP1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]23589329
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone binds to KEAP1 protein19808700
C0188552-tert-butylhydroquinone[2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]18512965
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]18512965
C0188552-tert-butylhydroquinoneCadmium Chloride inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]]18512965
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [CAV1 mutant form results in decreased expression of KEAP1 protein]"24709675
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of KEAP1 protein"24709675
C0930273-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone"KEAP1 protein inhibits the reaction [3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone affects the localization of HMOX1 protein]"19961840
C0930273-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone"KEAP1 protein inhibits the reaction [3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone affects the localization of NFE2L2 protein]"19961840
C5277963-morpholinopropyl isothiocyanate3-morpholinopropyl isothiocyanate results in decreased expression of KEAP1 protein20498004
C0283984-(2-pyridylazo)resorcinol4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]15865434
C0283984-(2-pyridylazo)resorcinol"4,4'-dipyridyl disulfide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]"15865434
C0283984-(2-pyridylazo)resorcinolHydrogen Peroxide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]15865434
C0283984-(2-pyridylazo)resorcinolsulforafan promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]15865434
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of KEAP1 mRNA"18648102
C0075424,4'-dipyridyl disulfide"4,4'-dipyridyl disulfide inhibits the reaction [5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate) binds to KEAP1 protein]"15865434
C0075424,4'-dipyridyl disulfide"4,4'-dipyridyl disulfide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]"15865434
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of KEAP1 mRNA"21346803
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide results in increased expression of KEAP1 mRNA26117601
C0137334-vinylcyclohexene4-vinylcyclohexene results in increased expression of KEAP1 mRNA24681254
C0357635,5'-bis(8-(phenylamino)-1-naphthalenesulfonate)"4,4'-dipyridyl disulfide inhibits the reaction [5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate) binds to KEAP1 protein]"15865434
C0357635,5'-bis(8-(phenylamino)-1-naphthalenesulfonate)"5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate) binds to KEAP1 protein"15865434
C5225895,6-dihydrocyclopenta-1,2-dithiole-3-thione"5,6-dihydrocyclopenta-1,2-dithiole-3-thione promotes the reaction [NFE2L2 protein binds to KEAP1 protein]"22558124
C5225895,6-dihydrocyclopenta-1,2-dithiole-3-thione"KEAP1 protein results in increased susceptibility to 5,6-dihydrocyclopenta-1,2-dithiole-3-thione"22558124
C5225895,6-dihydrocyclopenta-1,2-dithiole-3-thione"5,6-dihydrocyclopenta-1,2-dithiole-3-thione promotes the reaction [NFE2L2 protein binds to KEAP1 protein]"22558124
C5225895,6-dihydrocyclopenta-1,2-dithiole-3-thione"KEAP1 protein results in increased susceptibility to 5,6-dihydrocyclopenta-1,2-dithiole-3-thione"22558124
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA"27188386
C5798117-O-galloyltaxifolin7-O-galloyltaxifolin results in decreased expression of KEAP123294286
D000082AcetaminophenAcetaminophen results in decreased expression of KEAP1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of KEAP1 mRNA25881548
D000082AcetaminophenABCC3 protein affects the reaction [KEAP1 protein affects the glucuronidation of Acetaminophen]19246624
D000082AcetaminophenKEAP1 gene mutant form results in decreased susceptibility to Acetaminophen16293230|2549971
D000082AcetaminophenKEAP1 protein affects the glucuronidation of Acetaminophen19246624
D000082AcetaminophenKEAP1 protein affects the glutathionylation of Acetaminophen19246624
D000082AcetaminophenKEAP1 protein affects the sulfation of Acetaminophen19246624
D000082AcetaminophenKEAP1 results in increased susceptibility to Acetaminophen20404090
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein]19033392
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]]11909699
D000171AcroleinButhionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]19608619
D000171Acrolein[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein19608619
D000393Air PollutantsAir Pollutants results in decreased expression of KEAP1 mRNA28389379
D000393Air PollutantsAir Pollutants results in decreased expression of KEAP1 protein28389379
C050234altertoxin IIaltertoxin II results in increased expression of and affects the localization of KEAP1 protein27178040
D006710HomocysteineHomocysteine results in increased expression of KEAP1 protein22964297
D000638AmiodaroneAmiodarone results in decreased expression of KEAP1 mRNA17991464
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KEAP1 mRNA16483693
C000228aristolochic acid Iaristolochic acid I results in increased expression of KEAP1 protein24530882
C000228aristolochic acid I"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [aristolochic acid I results in increased expression of KEAP1 protein]"24530882
D001151ArsenicArsenic results in decreased expression of KEAP1 protein26385919
D001151ArsenicArsenic results in increased expression of KEAP1 mRNA14567983
D001151ArsenicArsenic results in increased expression of KEAP1 protein14567983
D001151ArsenicArsenic binds to KEAP1 protein19808700
D001151ArsenicKEAP1 protein affects the susceptibility to Arsenic19808700
C006632arsenic trioxidearsenic trioxide affects the reaction [KEAP1 protein results in increased expression of CCND1 protein]22684020
C006632arsenic trioxidearsenic trioxide results in increased expression of KEAP1 mRNA15894607|1941714
C006632arsenic trioxidearsenic trioxide results in increased expression of KEAP1 protein22684020
C006632arsenic trioxideKEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to arsenic trioxide]26708503
C006632arsenic trioxideKEAP1 mRNA results in increased susceptibility to arsenic trioxide26708503
C006632arsenic trioxideKEAP1 protein inhibits the reaction [arsenic trioxide results in decreased expression of CCND1 mRNA]22684020
C006632arsenic trioxideKEAP1 protein inhibits the reaction [arsenic trioxide results in increased expression of PPARG mRNA]22684020
C006632arsenic trioxideKEAP1 protein inhibits the reaction [arsenic trioxide results in increased expression of PPARG protein]22684020
C006632arsenic trioxideKEAP1 protein promotes the reaction [rosiglitazone results in increased susceptibility to arsenic trioxide]22684020
C006632arsenic trioxideKEAP1 protein promotes the reaction [troglitazone results in increased susceptibility to arsenic trioxide]22684020
C006632arsenic trioxideKEAP1 protein results in decreased susceptibility to arsenic trioxide22684020
C006632arsenic trioxideNFE2L2 protein promotes the reaction [arsenic trioxide results in increased expression of KEAP1 protein]22684020
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of KEAP1 mRNA15894607
C006632arsenic trioxidearsenic trioxide results in decreased expression of KEAP1 protein24634002
C015001arsenitearsenite results in decreased expression of KEAP1 mRNA22476201
C015001arsenitearsenite results in decreased expression of KEAP1 protein22476201
C015001arsenitearsenite results in increased expression of KEAP1 mRNA22476201
C015001arsenitearsenite results in increased expression of KEAP1 protein22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in decreased expression of NFE2L1 mRNA]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of GCLC mRNA]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of GCLC protein]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of GCLM mRNA]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of HMOX1 mRNA]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of NFE2L1 protein]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of NFE2L2 mRNA]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of NFE2L2 protein]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of NQO1 mRNA]22476201
C015001arseniteKEAP1 protein affects the reaction [arsenite results in increased expression of SRXN1 mRNA]22476201
C015001arseniteKEAP1 protein affects the susceptibility to arsenite22476201
C015001arseniteNFE2L2 protein inhibits the reaction [arsenite results in increased expression of KEAP1 mRNA]22476201
C015001arseniteNFE2L2 protein inhibits the reaction [arsenite results in increased expression of KEAP1 protein]22476201
C015001arseniteNFE2L2 protein promotes the reaction [arsenite results in decreased expression of KEAP1 mRNA]22476201
C015001arseniteNFE2L2 protein promotes the reaction [arsenite results in decreased expression of KEAP1 protein]22476201
D001280AtrazineAtrazine results in decreased expression of KEAP1 mRNA22378314
D001379AzathioprineKEAP1 protein affects the susceptibility to Azathioprine21803983
C487081belinostatbelinostat results in decreased expression of KEAP1 mRNA19606018
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KEAP1 mRNA20498004|2594648
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KEAP1 protein20498004
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KEAP1 mRNA20106945|2125695
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KEAP1 mRNA21569818|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KEAP1 mRNA"19150397
D016227BenzoquinonesBenzoquinones analog binds to and results in increased metabolism of KEAP1 protein21651925
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]18512965
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [NFE2L2 protein binds to KEAP1 protein]18512965
C034786bis(4-hydroxycinnamoyl)methaneKEAP1 protein inhibits the reaction [bis(4-hydroxycinnamoyl)methane results in increased expression of HMOX1 mRNA]17535857
C017807bisbenzimide ethoxide trihydrochlorideKEAP1 protein results in decreased export of bisbenzimide ethoxide trihydrochloride25841332
C006780bisphenol Abisphenol A results in increased expression of KEAP1 mRNA23606268
C006780bisphenol A[nonylphenol co-treated with bisphenol A] results in increased expression of KEAP1 mRNA23606268
C006780bisphenol Abisphenol A affects the expression of KEAP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KEAP1 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide affects the localization of KEAP1 protein21601586
D001761BleomycinBleomycin results in decreased expression of KEAP1 protein26768587
D001761Bleomycintripterine inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein]26768587
C020237brusatol[KEAP1 protein results in decreased expression of NFE2L2 protein] which results in decreased susceptibility to brusatol21205897
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]19608619
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]19608619
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]19608619
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]19608619
D020122tert-ButylhydroperoxidePlant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein]27050144
D020122tert-ButylhydroperoxideQuercetin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein]27050144
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of KEAP1 protein27050144
D002104CadmiumCadmium results in increased degradation of KEAP1 protein27658547
C028031cadmium acetatecadmium acetate results in decreased expression of KEAP1 protein29140578
C028031cadmium acetateTrehalose inhibits the reaction [cadmium acetate results in decreased expression of KEAP1 protein]29140578
D019256Cadmium ChlorideKEAP1 protein inhibits the reaction [Cadmium Chloride results in increased expression of MT1E mRNA]26827822
D019256Cadmium ChlorideCadmium Chloride affects the reaction [NFE2L2 protein binds to KEAP1 protein]18512965
D019256Cadmium Chloride[Cadmium Chloride affects the reaction [NFE2L2 protein binds to KEAP1 protein]] affects the localization of [NFE2L2 protein binds to KEAP1 protein]18512965
D019256Cadmium ChlorideCadmium Chloride binds to KEAP1 protein19808700|2682782
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]]18512965
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [KEAP1 gene mutant form results in increased expression of NFE2L2 protein]26827822
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of KEAP1 mRNA20061341
D019256Cadmium ChlorideKEAP1 gene mutant form promotes the reaction [Cadmium Chloride results in increased expression of NFE2L2 protein]26827822
D019256Cadmium ChlorideCadmium Chloride results in increased expression of KEAP1 protein26462792
D019256Cadmium Chloride[Grape Seed Proanthocyanidins co-treated with Cadmium Chloride] affects the expression of KEAP1 mRNA25719599
D019256Cadmium Chloride[Grape Seed Proanthocyanidins co-treated with Cadmium Chloride] affects the expression of KEAP1 protein25719599
D019256Cadmium ChlorideGrape Seed Proanthocyanidins inhibits the reaction [Cadmium Chloride results in increased expression of KEAP1 protein]26462792
D002246Carbon DisulfideCarbon Disulfide results in decreased expression of KEAP1 protein27530093
D002248Carbon MonoxideCarbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]18845810
D047188ChalconesChalcones analog results in decreased expression of KEAP1 protein23963778
D002699ChlorambucilButhionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]19608619
D002699Chlorambucil[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil19608619
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of KEAP1 mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of KEAP1 mRNA26272509
D002794CholineKEAP1 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CD36 mRNA]20350562
D002794CholineKEAP1 affects the susceptibility to [Choline deficiency co-treated with Methionine deficiency]20350562
D002794CholineNFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of KEAP1 mRNA]20350562
C059262cidofovircidofovir results in increased expression of KEAP1 mRNA25596134
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of KEAP1 protein19033392
C012843cinnamic aldehydecinnamic aldehyde affects the expression of KEAP1 mRNA28219650
C028677clivorineclivorine results in increased expression of KEAP1 mRNA25881548
D004002Clodronic AcidClodronic Acid results in increased expression of KEAP1 mRNA25596134
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNA17602206
D003035CobaltCobalt binds to KEAP1 protein15865434
D003035CobaltZinc inhibits the reaction [Cobalt binds to KEAP1 protein]15865434
C018021cobaltous chloridecobaltous chloride results in increased expression of KEAP1 mRNA24386269
D009249NADPKEAP1 protein affects the abundance of NADP21775727
D003300CopperCopper results in increased expression of KEAP1 mRNA25461751
C007164cumene hydroperoxideButhionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]19608619
C007164cumene hydroperoxide[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide19608619
D003474CurcuminCurcumin results in increased expression of KEAP1 mRNA23710286
D003474CurcuminCurcumin results in increased expression of KEAP1 mRNA21256849
D003474CurcuminCurcumin analog results in decreased expression of KEAP1 protein26991801
D003474CurcuminKEAP1 protein inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]17535857
C057862cyanoginosin LRcyanoginosin LR binds to KEAP1 protein20722399
D016572CyclosporineCyclosporine results in increased expression of KEAP1 mRNA25596134
D016572CyclosporineCyclosporine results in decreased expression of KEAP1 mRNA25596134
C014347decitabine[decitabine affects the methylation of KEAP1 promoter] which affects the expression of KEAP1 mRNA18555005|1855500
C014347decitabinedecitabine results in increased expression of KEAP1 mRNA20124447
C050229demethoxycurcuminKEAP1 protein inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]17535857
C031710dexamethasone 21-methanesulfonatedexamethasone 21-methanesulfonate affects the metabolism of KEAP1 protein18785192
C031710dexamethasone 21-methanesulfonatedexamethasone 21-methanesulfonate binds to KEAP1 protein15865434
C031710dexamethasone 21-methanesulfonateEdetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein]15865434
C031710dexamethasone 21-methanesulfonateEgtazic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein]15865434
C031710dexamethasone 21-methanesulfonate"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein]"15865434
C042577diallyl trisulfidediallyl trisulfide binds to KEAP1 protein24489685
C042577diallyl trisulfidediallyl trisulfide promotes the reaction [KEAP1 mutant form affects the localization of NFE2L2 protein]24489685
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of KEAP1 protein23453443
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KEAP1 mRNA17361019
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of KEAP1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of KEAP1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of KEAP1 mRNA25596134|2759478
D002945Cisplatin[KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Cisplatin20530669
D002945CisplatinKEAP1 protein results in increased susceptibility to Cisplatin25841332
D004026DieldrinDieldrin results in decreased expression of KEAP1 mRNA23041725
D004040Dietary Carbohydrates[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein21289251
D004040Dietary Carbohydrates[resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein]21289251
D004040Dietary Carbohydrates[resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein]21289251
D004041Dietary Fats[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein21289251
D004041Dietary Fats[resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein]21289251
D004041Dietary Fats[resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein]21289251
D004041Dietary FatsDietary Fats results in decreased expression of KEAP1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of KEAP1 protein23551926
D004041Dietary FatsFish Oils inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]23551926
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]23551926
C014476diethyl maleatediethyl maleate results in increased expression of KEAP1 protein27358234
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of KEAP1 mRNA17602206
C039060dihydroartemisinindihydroartemisinin analog binds to KEAP1 protein26340163
C472036dihydromyricetin[dihydromyricetin co-treated with Ethanol] results in decreased expression of KEAP1 protein28419832
D004112DimercaprolDimercaprol binds to KEAP1 protein19808700
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of KEAP1 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 mRNA"24995432
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 protein"24995432
D0151279,10-Dimethyl-1,2-benzanthracene"tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 mRNA]"24995432
D0151279,10-Dimethyl-1,2-benzanthracene"tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 protein]"24995432
D004137DinitrochlorobenzeneAcetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein]19033392
D004137DinitrochlorobenzeneDinitrochlorobenzene promotes the reaction [KEAP1 protein binds to KEAP1 protein]25742418
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of KEAP1 protein19033392
D004137Dinitrochlorobenzenetetrachlorobenzoquinone promotes the reaction [Dinitrochlorobenzene promotes the reaction [KEAP1 protein binds to KEAP1 protein]]25742418
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the metabolism of KEAP1 protein18785192
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of KEAP1 mRNA28219650
C019357dioscindioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein]28082111
D004178DiquatKEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]22762311
D004178Diquat[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA22762311
D004178DiquatKEAP1 gene mutant form inhibits the reaction [NFE2L2 gene mutant form results in increased susceptibility to Diquat]22762311
D004281Docosahexaenoic AcidsDocosahexaenoic Acids inhibits the reaction [KEAP1 protein binds to CUL3 protein]25742418
D004317DoxorubicinKEAP1 mRNA results in increased susceptibility to Doxorubicin26708503
D004317DoxorubicinKEAP1 protein results in decreased export of and results in increased susceptibility to Doxorubicin25841332
D004317DoxorubicinKEAP1 protein results in decreased susceptibility to Doxorubicin22684020
D004317Doxorubicindioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein]28082111
D004317DoxorubicinDoxorubicin results in decreased expression of KEAP1 protein24211725
D004317DoxorubicinDoxorubicin results in increased degradation of KEAP1 protein24211725
D004317DoxorubicinDoxorubicin results in increased expression of KEAP1 protein28082111
D004317DoxorubicinKEAP1 protein affects the susceptibility to Doxorubicin24211725
D004492Edetic AcidEdetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein]15865434
D004533Egtazic AcidEgtazic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein]15865434
D000431Ethanol[dihydromyricetin co-treated with Ethanol] results in decreased expression of KEAP1 protein28419832
D005000EthionamideKEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to arsenic trioxide]26708503
D005047EtoposideKEAP1 mRNA results in increased susceptibility to Etoposide26708503
D005047EtoposideKEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein]27982581
D005047EtoposideKEAP1 protein results in decreased susceptibility to Etoposide22684020
C034379falcarindiolfalcarindiol affects the folding of KEAP1 protein20026152
C034379falcarindiolfalcarindiol binds to and results in increased alkylation of KEAP1 protein20026152
C034379falcarindiolfalcarindiol inhibits the reaction [KEAP1 protein results in decreased activity of NFE2L2 protein]20026152
C034379falcarindiolfalcarindiol results in decreased activity of KEAP1 protein20026152
C034379falcarindiolGlutathione inhibits the reaction [falcarindiol binds to and results in increased alkylation of KEAP1 protein]20026152
C015881farrerolfarrerol results in decreased expression of KEAP1 protein26111761
D018120FinasterideFinasteride results in increased expression of KEAP1 mRNA24136188
D005395Fish OilsFish Oils inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]23551926
D005419FlavonoidsFlavonoids results in decreased expression of KEAP1 mRNA18035473
D005472FluorouracilKEAP1 protein affects the susceptibility to Fluorouracil18692501
D005485FlutamideFlutamide results in increased expression of KEAP1 mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of KEAP1 mRNA19167457
C419708gefitinibgefitinib results in increased expression of KEAP1 mRNA27639429
D005907GliclazideGliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]21439372
D005907GliclazideGliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein]21439372
D005947Glucose[NFE2L2 protein co-treated with KEAP1 protein] affects the abundance of Glucose23017736
D005978GlutathioneButhionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]19608619
D005978Glutathione[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione19608619
D005978Glutathione[Plant Extracts results in decreased expression of KEAP1 protein] which results in increased chemical synthesis of Glutathione21972102
D005978Glutathione"Glutathione inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein]"25807370
D005978Glutathione"Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased glutathionylation of KEAP1 protein]"20800667
D005978GlutathioneKEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]22762311
D005978Glutathione[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA22762311
D005978GlutathioneKEAP1 gene mutant form results in increased abundance of Glutathione26827822
D005978GlutathioneGlutathione inhibits the reaction [falcarindiol binds to and results in increased alkylation of KEAP1 protein]20026152
C511402Grape Seed Proanthocyanidins[Grape Seed Proanthocyanidins co-treated with Cadmium Chloride] affects the expression of KEAP1 mRNA25719599
C511402Grape Seed Proanthocyanidins[Grape Seed Proanthocyanidins co-treated with Cadmium Chloride] affects the expression of KEAP1 protein25719599
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins inhibits the reaction [Cadmium Chloride results in increased expression of KEAP1 protein]26462792
D006427HeminHemin results in decreased expression of KEAP1 protein27777014
C015924histidyl-proline diketopiperazinehistidyl-proline diketopiperazine affects the localization of KEAP1 protein19735445
C015924histidyl-proline diketopiperazineKEAP1 mRNA affects the susceptibility to histidyl-proline diketopiperazine19735445
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [KEAP1 protein binds to KEAP1 protein]25742418
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of KEAP1 mRNA23410634
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]15865434
D006894HydroxyestronesHydroxyestrones binds to KEAP1 protein19952498
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of KEAP1 mRNA17572062
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of KEAP1 mRNA17980396
D007069IfosfamideIfosfamide results in increased expression of KEAP1 mRNA25596134
D007213IndomethacinAcetylcysteine inhibits the reaction [Indomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]]11909699
D007213IndomethacinIndomethacin inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]11909699
D007213IndomethacinKEAP1 protein inhibits the reaction [Indomethacin results in increased expression of GCLC mRNA]11909699
D007460IodoacetamideIodoacetamide inhibits the reaction [sulforafan results in increased metabolism of KEAP1 protein]21391649
D007460IodoacetamideIodoacetamide results in increased expression of KEAP1 protein27358234
D007460IodoacetamideIodoacetamide affects the metabolism of KEAP1 protein18785192
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of KEAP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [oltipraz results in increased expression of KEAP1 mRNA]27233051
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of KEAP1 mRNA27233051
C561695(+)-JQ1 compoundoltipraz promotes the reaction [(+)-JQ1 compound results in increased expression of KEAP1 mRNA]27233051
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KEAP1 mRNA23430699|2476305
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KEAP1 protein24733848
C410337K 7174K 7174 results in increased expression of KEAP1 mRNA24086573
D048628KetolidesKetolides analog results in decreased expression of KEAP1 mRNA24967691
D064747LansoprazoleLansoprazole results in increased oxidation of KEAP1 protein19628634
C045463leflunomideleflunomide results in increased expression of KEAP1 mRNA24136188
C038018liliallilial results in increased expression of KEAP1 protein19033392
C002385linsidomineKEAP1 mRNA affects the susceptibility to linsidomine16092930
C482199lipopolysaccharide, E coli O55-B5"KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NQO1 mRNA]"23906629
C482199lipopolysaccharide, E coli O55-B5"Thiophenes inhibits the reaction [KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]"23906629
C482199lipopolysaccharide, E coli O55-B5"IKBKB gene mutant form inhibits the reaction [KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CD36 mRNA]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 mRNA]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NQO1 mRNA]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 protein affects the reaction [lipopolysaccharide, E coli O55-B5 affects the expression of CHUK protein]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 protein affects the reaction [lipopolysaccharide, E coli O55-B5 affects the expression of IKBKB protein]"23906629
C482199lipopolysaccharide, E coli O55-B5"KEAP1 protein affects the reaction [lipopolysaccharide, E coli O55-B5 affects the phosphorylation of and affects the expression of RELA protein]"23906629
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 promotes the reaction [KEAP1 gene mutant form results in increased expression of NFE2L2 protein]"23906629
C440499lipopolysaccharide, Escherichia coli O111 B4"[Plant Preparations co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of KEAP1 protein"24675710
D008294MalathionKEAP1 protein results in increased susceptibility to Malathion21896655
C025340manganese chloridemanganese chloride affects the expression of KEAP1 protein25288107
C025340manganese chlorideMelatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein]25288107
D008550MelatoninMelatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein]25288107
D008550MelatoninMelatonin results in decreased expression of KEAP1 protein25288107
C042720mercuric bromidemercuric bromide results in increased expression of KEAP1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA"27188386
D008687MetforminMetformin results in decreased expression of KEAP1 mRNA25596134
D008715MethionineKEAP1 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CD36 mRNA]20350562
D008715MethionineKEAP1 affects the susceptibility to [Choline deficiency co-treated with Methionine deficiency]20350562
D008715MethionineNFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of KEAP1 mRNA]20350562
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in increased expression of KEAP1 protein"27358234
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [aristolochic acid I results in increased expression of KEAP1 protein]"24530882
D008748MethylcholanthreneMethylcholanthrene results in increased expression of KEAP1 mRNA23712962
D008767Methylmercury CompoundsMethylmercury Compounds inhibits the reaction [KEAP1 gene mutant form results in increased expression of NFE2L2 protein]26827822
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of KEAP1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of KEAP1 promoter"26251327
C517880monascinmonascin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein]23331247
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [KEAP1 protein mutant form results in increased ubiquitination of NFE2L2 protein]18417180
C406082monomethylarsonous acidmonomethylarsonous acid inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]18417180
C406082monomethylarsonous acidmonomethylarsonous acid promotes the reaction [KEAP1 protein binds to CUL3 protein]18417180
C406082monomethylarsonous acidmonomethylarsonous acid promotes the reaction [KEAP1 protein binds to NFE2L2 protein]18417180
C028473N-acetyl-4-benzoquinoneimineKEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]19246624
C028473N-acetyl-4-benzoquinoneimineN-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein18785192
C051752nefazodonenefazodone results in increased expression of KEAP1 mRNA24136188
D009532NickelNickel results in increased expression of KEAP1 protein19033392
C028007nickel monoxidenickel monoxide results in increased expression of KEAP1 mRNA19167457
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein]"15865434
C025256nonylphenol[nonylphenol co-treated with bisphenol A] results in increased expression of KEAP1 mRNA23606268
C025256nonylphenolnonylphenol results in increased expression of KEAP1 mRNA23606268
D016627OxidopamineKEAP1 mRNA affects the susceptibility to Oxidopamine16092930
D016627OxidopamineOxidopamine promotes the reaction [NFE2L2 protein binds to KEAP1 protein]23274087
C026209oltipraz(+)-JQ1 compound promotes the reaction [oltipraz results in increased expression of KEAP1 mRNA]27233051
C026209oltiprazoltipraz promotes the reaction [(+)-JQ1 compound results in increased expression of KEAP1 mRNA]27233051
C026209oltiprazoltipraz results in increased expression of KEAP1 mRNA27233051
C029341oxophenylarsineoxophenylarsine binds to KEAP1 protein19786557|1980870
D010100OxygenOxygen deficiency results in decreased expression of KEAP1 mRNA25596134
D017239Paclitaxel[KEAP1 protein results in decreased stability of NFE2L2 protein] which results in increased susceptibility to Paclitaxel20530669
D000073878Palm OilPalm Oil results in decreased expression of KEAP1 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of KEAP1 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KEAP1 mRNA20621739
C033342perillaldehydeKEAP1 protein inhibits the reaction [perillaldehyde results in increased expression of TXN mRNA]19123792
D010590PhalloidineKEAP1 gene mutant form inhibits the reaction [Phalloidine results in increased expression of CXCL1 mRNA]25280775
D010590PhalloidineKEAP1 gene mutant form inhibits the reaction [Phalloidine results in increased expression of CXCL2 mRNA]25280775
D010590PhalloidineKEAP1 gene mutant form inhibits the reaction [Phalloidine results in increased expression of DDIT3 mRNA]25280775
D010590PhalloidineKEAP1 gene mutant form inhibits the reaction [Phalloidine results in increased expression of GADD45A mRNA]25280775
D010590PhalloidineKEAP1 gene mutant form inhibits the reaction [Phalloidine results in increased expression of HMOX1 mRNA]25280775
D010590PhalloidineKEAP1 gene mutant form results in decreased susceptibility to Phalloidine25280775
D010590Phalloidine[KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of CXCL1 mRNA25280775
D010590Phalloidine[KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of CXCL2 mRNA25280775
D010590Phalloidine[KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of DDIT3 mRNA25280775
D010590Phalloidine[KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of GADD45A mRNA25280775
D010590Phalloidine[KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in decreased expression of HMOX1 mRNA25280775
D010590Phalloidine[KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in increased expression of MT1 mRNA25280775
D010590Phalloidine[KEAP1 gene mutant form results in decreased susceptibility to Phalloidine] which results in increased expression of SLCO1B2 mRNA25280775
D010590PhalloidinePhalloidine promotes the reaction [KEAP1 gene mutant form results in increased expression of NFE2L2 mRNA]25280775
D010590PhalloidinePhalloidine promotes the reaction [KEAP1 gene mutant form results in increased expression of NQO1 mRNA]25280775
D010634PhenobarbitalKEAP1 protein affects the reaction [Phenobarbital results in increased expression of CYP6A2 mRNA]21896655
D010634PhenobarbitalKEAP1 protein affects the reaction [Phenobarbital results in increased expression of CYP6A8 mRNA]21896655
D010634PhenobarbitalKEAP1 protein affects the reaction [Phenobarbital results in increased expression of GSTD2 mRNA]21896655
D010634PhenobarbitalKEAP1 protein affects the reaction [Phenobarbital results in increased expression of GSTD7 mRNA]21896655
D010634PhenobarbitalKEAP1 protein affects the reaction [Phenobarbital results in increased expression of JHEH1 mRNA]21896655
D010634PhenobarbitalPhenobarbital results in increased expression of KEAP1 mRNA21896655
D010634PhenobarbitalKEAP1 protein affects the reaction [Phenobarbital results in increased expression of CYP2A5 mRNA]22859313
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KEAP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KEAP1 mRNA26272509
D010695PhlorhizinPhlorhizin results in increased expression of KEAP1 mRNA22538082
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KEAP1 mRNA19710929
D010936Plant ExtractsPlant Extracts inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein]27050144
D010936Plant ExtractsPlant Extracts results in decreased expression of KEAP1 protein21972102
D010936Plant Extracts[Plant Extracts results in decreased expression of KEAP1 protein] which results in increased chemical synthesis of Glutathione21972102
D010936Plant Extracts[resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein]21289251
D028321Plant Preparations"[Plant Preparations co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of KEAP1 protein"24675710
D028321Plant PreparationsPlant Preparations results in decreased expression of KEAP1 mRNA24973489
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of KEAP1 protein24361488
D059808Polyphenols[resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein]21289251
D011192Potassium DichromatePotassium Dichromate affects the localization of and results in decreased ubiquitination of KEAP1 protein17420218
D011192Potassium DichromatePotassium Dichromate inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]17420218
C107773pterostilbenepterostilbene inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]26700463
D011794QuercetinQuercetin inhibits the reaction [tert-Butylhydroperoxide results in increased expression of KEAP1 protein]27050144
D011794QuercetinQuercetin results in increased metabolism of and results in increased degradation of and results in decreased expression of KEAP1 protein17462537
D011794QuercetinQuercetin results in increased expression of KEAP1 mRNA23295412
D011794QuercetinQuercetin results in decreased expression of KEAP1 protein25339115
C012526quercitrinquercitrin results in increased expression of KEAP1 mRNA25193878
C502851quinocetonequinocetone results in decreased expression of KEAP1 protein27046791
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in increased expression of KEAP1 mRNA25800948
C059514resveratrol[resveratrol co-treated with Plant Extracts] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein]21289251
C059514resveratrol[resveratrol co-treated with Polyphenols] inhibits the reaction [[Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of KEAP1 protein]21289251
C059514resveratrolresveratrol inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]16948474
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of KEAP1 protein]23551926
C059514resveratrolresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]21439372
C059514resveratrolresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein]21439372
C059514resveratrolKEAP1 protein inhibits the reaction [resveratrol results in decreased activity of TNF protein]20418481
C059514resveratrolKEAP1 protein inhibits the reaction [resveratrol results in increased expression of GCLC mRNA]20418481
C059514resveratrolKEAP1 protein inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]20418481
C059514resveratrolKEAP1 protein inhibits the reaction [resveratrol results in increased expression of NQO1 mRNA]20418481
C059514resveratrol[KEAP1 protein results in decreased activity of NFE2L2 protein] which results in decreased susceptibility to resveratrol20418481
C059514resveratrolKEAP1 protein results in decreased susceptibility to resveratrol20418481
C089730rosiglitazoneKEAP1 protein promotes the reaction [rosiglitazone results in increased susceptibility to arsenic trioxide]22684020
C089730rosiglitazonerosiglitazone results in increased expression of KEAP1 mRNA25596134
C089730rosiglitazonerosiglitazone results in increased expression of KEAP1 mRNA25596134
D012402RotenoneKEAP1 gene mutant form results in decreased susceptibility to Rotenone19167360
D012402RotenoneRotenone results in decreased expression of KEAP1 mRNA23186747
D012402Rotenone[safranal co-treated with Rotenone] affects the expression of KEAP128145852
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of KEAP1 mRNA21427059
C087963safranal[safranal co-treated with Rotenone] affects the expression of KEAP128145852
D012643SeleniumSelenium results in increased expression of KEAP1 mRNA19244175
C040115shogaolshogaol metabolite results in decreased expression of KEAP1 protein25148906
C040115shogaolshogaol results in decreased expression of KEAP1 protein25148906
C040115shogaolshogaol results in increased alkylation of KEAP1 protein25148906
C040115shogaolKEAP1 protein affects the reaction [shogaol analog results in increased expression of HMOX1 protein]23899529
C040115shogaolKEAP1 protein affects the reaction [shogaol analog results in increased expression of NFE2L2 protein]23899529
C040115shogaolKEAP1 protein affects the reaction [shogaol analog results in increased expression of NQO1 protein]23899529
C440975silybinsilybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1]24062023
D012838SilymarinSilymarin inhibits the reaction [S100B protein results in increased expression of KEAP1 protein]23331247
C017947sodium arseniteKEAP1 protein promotes the reaction [sodium arsenite results in increased expression of and results in increased activity of NFE2L2 protein]23589329
C017947sodium arsenitesodium arsenite affects the localization of KEAP1 protein23589329
C017947sodium arsenitesodium arsenite inhibits the reaction [KEAP1 protein mutant form results in increased ubiquitination of NFE2L2 protein]18417180
C017947sodium arsenitesodium arsenite inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]18417180
C017947sodium arsenitesodium arsenite promotes the reaction [KEAP1 protein binds to CUL3 protein]18417180
C017947sodium arsenitesodium arsenite promotes the reaction [KEAP1 protein binds to NFE2L2 protein]18417180
C017947sodium arsenitesodium arsenite results in decreased expression of KEAP1 protein28229933
C017947sodium arsenitesulforafan inhibits the reaction [sodium arsenite affects the localization of KEAP1 protein]23589329
C017947sodium arsenitesodium arsenite inhibits the reaction [[CUL3 protein binds to KEAP1 protein] which binds to and results in increased ubiquitination of NFE2L2 protein]16785233
C017947sodium arsenitesodium arsenite results in increased expression of KEAP1 mRNA26371860
C017947sodium arsenitesodium arsenite results in increased expression of KEAP1 protein26371860
C017947sodium arsenitesilybin inhibits the reaction [sodium arsenite results in increased expression of KEAP1]24062023
C017947sodium arsenitesodium arsenite affects the expression of KEAP1 mRNA25625412
C017947sodium arsenitesodium arsenite results in increased expression of KEAP124062023
C016104sodium bichromatesodium bichromate results in decreased expression of KEAP1 mRNA22155349
C017719solanesolsolanesol inhibits the reaction [KEAP1 protein binds to CUL3 protein binds to RBX1 protein]25645596
C017719solanesolsolanesol inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]25645596
D013311StreptozocinGliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]21439372
D013311StreptozocinGliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein]21439372
D013311Streptozocinresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]21439372
D013311Streptozocinresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein]21439372
D013311Streptozocin[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA21439372
D013311Streptozocin[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein21439372
D013448SulfobromophthaleinKEAP1 protein results in decreased glutathionylation of Sulfobromophthalein19246623
D013448SulfobromophthaleinKEAP1 protein results in decreased transport of Sulfobromophthalein19246623
C016766sulforafanIodoacetamide inhibits the reaction [sulforafan results in increased metabolism of KEAP1 protein]21391649
C016766sulforafanKEAP1 protein mutant form inhibits the reaction [sulforafan results in increased expression of and results in increased activity of NFE2L2 protein]23589329
C016766sulforafanKEAP1 protein mutant form results in decreased susceptibility to sulforafan23589329
C016766sulforafanKEAP1 protein promotes the reaction [sulforafan results in increased expression of and results in increased activity of NFE2L2 protein]23589329
C016766sulforafanKEAP1 protein results in increased susceptibility to sulforafan22558124
C016766sulforafansulforafan inhibits the reaction [KEAP1 protein binds to CUL3 protein]18417180
C016766sulforafansulforafan inhibits the reaction [sodium arsenite affects the localization of KEAP1 protein]23589329
C016766sulforafansulforafan promotes the reaction [KEAP1 protein binds to NFE2L2 protein]18417180
C016766sulforafansulforafan promotes the reaction [NFE2L2 protein binds to KEAP1 protein]22558124
C016766sulforafansulforafan results in increased expression of KEAP1 protein19033392
C016766sulforafansulforafan results in increased metabolism of KEAP1 protein21391649
C016766sulforafanKEAP1 protein results in increased susceptibility to sulforafan22558124
C016766sulforafansulforafan promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]15865434
C016766sulforafansulforafan promotes the reaction [NFE2L2 protein binds to KEAP1 protein]22558124
C016766sulforafansulforafan inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]18417180
D013467SulindacSulindac results in decreased expression of KEAP1 mRNA24136188
C473643sulphoraphenesulphoraphene results in increased expression of KEAP1 mRNA29247643
C059006tangeretin"tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 mRNA]"24995432
C059006tangeretin"tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 protein]"24995432
C531972TBE 31TBE 31 binds to KEAP1 protein21361338
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone promotes the reaction [Dinitrochlorobenzene promotes the reaction [KEAP1 protein binds to KEAP1 protein]]25742418
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone promotes the reaction [KEAP1 protein binds to KEAP1 protein]25742418
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased ubiquitination of KEAP1 protein25742418
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KEAP1 mRNA21570461
D019284ThapsigarginThapsigargin results in increased expression of KEAP1 protein27358234
D008063Thioctic AcidThioctic Acid results in increased expression of KEAP1 protein19033392
D013876Thiophenes"Thiophenes inhibits the reaction [KEAP1 gene mutant form promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]"23906629
D014199TrehaloseTrehalose inhibits the reaction [cadmium acetate results in decreased expression of KEAP1 protein]29140578
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of KEAP1 mRNA15894607
C012589trichostatin Atrichostatin A affects the expression of KEAP1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of KEAP1 mRNA15901671
C050414tripterinetripterine inhibits the reaction [Bleomycin results in decreased expression of KEAP1 protein]26768587
C057693troglitazoneKEAP1 protein promotes the reaction [troglitazone results in increased susceptibility to arsenic trioxide]22684020
C406224valdecoxibvaldecoxib results in increased expression of KEAP1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of KEAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KEAP1 mRNA22083351|2915479
D014635Valproic AcidValproic Acid results in decreased expression of KEAP1 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of KEAP1 mRNA15901671
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of KEAP1 mRNA17459161
D009536NiacinamideGliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]21439372
D009536NiacinamideGliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein]21439372
D009536Niacinamideresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]21439372
D009536Niacinamideresveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein]21439372
D009536Niacinamide[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA21439372
D009536Niacinamide[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein21439372
D024483Vitamin K 3[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Vitamin K 319608619
D024483Vitamin K 3Vitamin K 3 results in decreased expression of KEAP1 mRNA23410634
D015032Zinc4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]15865434
D015032Zinc"4,4'-dipyridyl disulfide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]"15865434
D015032ZincHydrogen Peroxide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]15865434
D015032Zincsulforafan promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]]15865434
D015032ZincZinc binds to KEAP1 protein15865434
D015032ZincZinc inhibits the reaction [Cobalt binds to KEAP1 protein]15865434

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  16888629  17015834  17510365  18757741  19424503  
19615732  19706542  20173742  20452972  20562859  20600852  
21044950  21516116  21903422  21988832  23274085  24089205  
25416956  25910212  26517842  26649820  27107014  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-IPI17015834  
GO:0042803protein homodimerization activity-IEA-  
GO:0097718disordered domain specific binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0010499proteasomal ubiquitin-independent protein catabolic process-IDA15983046  
GO:0016567protein ubiquitination-IDA15983046  
GO:0016567protein ubiquitination-IEA-  
GO:0016579protein deubiquitination-TAS-  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-TAS17015834  
GO:0042994cytoplasmic sequestering of transcription factor-IBA21873635  
GO:0043433negative regulation of DNA-binding transcription factor activity-TAS17015834  
GO:0043687post-translational protein modification-TAS-  
GO:0045604regulation of epidermal cell differentiation-IEA-  
GO:0071353cellular response to interleukin-4-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA19424503  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005815microtubule organizing center-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS17015834  
GO:0005884actin filament-IEA-  
GO:0030496midbody-IDA15166316  
GO:0031463Cul3-RING ubiquitin ligase complex-IDA15983046  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19822148Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK. (2009 Nov 3)Goven DFEBS Lett
29787640Elevated levels of 8-OHdG and PARK7/DJ-1 in peri-implantitis mucosa. (2018 May 22)Kasnak GClin Implant Dent Relat Res
29793178Nrf2/P-glycoprotein axis is associated with clinicopathological characteristics in colorectal cancer. (2018 May 21)Sadeghi MRBiomed Pharmacother
20938484Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. (2007 Dec)Liu ZJ Neurochem
28256572Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities. (2017 Jun)Yoshida AMod Pathol
24137397Keap1 mutations in lung cancer patients. (2013 Sep)Sasaki HOncol Lett
24131734Acrolein exposure suppresses antigen-induced pulmonary inflammation. (2013 Oct 16)Spiess PCRespir Res
18757741Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. (2008 Sep 9)Shibata TProc Natl Acad Sci U S A
19671143Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population. (2009 Aug 11)Siedlinski MRespir Res
18559366Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. (2008 Oct)Goven DThorax
22686525Nrf2: friend and foe in preventing cigarette smoking-dependent lung disease. (2012 Sep 17)Muller TChem Res Toxicol
27806574Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis. (2017 Jan 17)Penning TMChem Res Toxicol
23075683[Keap1 expression for predicting the chemoresistance and prognosis of advanced non-small cell lung cancer]. (2012 Oct)Cao BZhongguo Fei Ai Za Zhi
23954767Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity. (2013 Nov 1)Li YToxicol Appl Pharmacol
25278450Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome. (2014 Dec 1)Karlsson AClin Cancer Res
28464886A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells. (2017 May 2)Yeo JBMC Cancer
29587953[Nrf2 and Keap1 Abnormalities in 104 Lung Adenocarcinoma Cases and Association with Clinicopathologic Features]. (2018 Mar 20)Xiao YZhongguo Fei Ai Za Zhi
18556627Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. (2008 Sep 15)Malhotra DAm J Respir Crit Care Med
20153624alpha-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells. (2010 Dec)Feng ZJ Nutr Biochem
28433662Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis. (2017 Jul)Toyokuni SFree Radic Biol Med
26540911[The expression of Nrf2 and Keap1 in laryngeal carcinoma and its clinical indication]. (2015 Jul)Yuan YLin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
26599269Mutation Profiling of Lung Cancers with Long-Term Response to Gefitinib Therapy. (2015)Gautschi OOncol Res Treat