Gene info: ID 9829

Gene: DNAJC6

GENE ID: 9829

Synonyms: DJC6|PARK19

Description: DnaJ heat shock protein family (Hsp40) member C6

Gene type: protein-coding

Location: 1p31.3

dbXrefs: Ensembl:ENSG00000116675 MIM:608375 Vega:OTTHUMG00000009066 UniprotKB:O75061

RefSeq: NG_033843.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.486e-2 (AD) 6.013e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg07996785	chr1:65775125	DNAJC6		3.700e-9	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SRPK2	0.983
WDR47	0.973
SYNJ1	0.969
ATP6V1A	0.969
KIF3A	0.969
CLCN4	0.967
WDR7	0.967
G3BP2	0.967
DNM3	0.966
PPM1H	0.966

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSAG1	-0.53
RNF135	-0.514
CHST14	-0.47
OR4F5	-0.467
SYDE1	-0.465
RHOD	-0.46
INHBB	-0.459
RAB13	-0.457
MAGEA12	-0.447
GJB2	-0.445

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAJC6 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAJC6 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAJC6 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAJC6 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAJC6 mRNA"	25510870
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJC6 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJC6 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJC6 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJC6 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJC6 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJC6 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of DNAJC6 mRNA	29067470
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of DNAJC6 mRNA	28522335
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of DNAJC6 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of DNAJC6 gene	25304211
C015001	arsenite	arsenite results in increased methylation of DNAJC6 promoter	23974009
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DNAJC6 mRNA"	19150397
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in decreased expression of DNAJC6 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in decreased expression of DNAJC6 mRNA	26496021
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of DNAJC6 mRNA	26496021
C006780	bisphenol A	bisphenol A results in decreased expression of DNAJC6 mRNA	25181051
C013418	bromfenacoum	bromfenacoum results in decreased expression of DNAJC6 protein	28903499
D002220	Carbamazepine	Carbamazepine affects the expression of DNAJC6 mRNA	24752500
D016572	Cyclosporine	Cyclosporine results in decreased expression of DNAJC6 mRNA	27989131
D004008	Diclofenac	Diclofenac affects the expression of DNAJC6 mRNA	24752500
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNAJC6 mRNA	28085963
D005557	Formaldehyde	Formaldehyde results in increased expression of DNAJC6 mRNA	23649840
D017313	Fenretinide	Fenretinide results in decreased expression of DNAJC6 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of DNAJC6 mRNA	28973697
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of DNAJC6 mRNA	24435446\|2479639
D007854	Lead	Lead affects the expression of DNAJC6 mRNA	28903495
C045463	leflunomide	leflunomide results in increased expression of DNAJC6 mRNA	28988120
C042720	mercuric bromide	mercuric bromide results in increased expression of DNAJC6 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJC6 mRNA"	27188386
D008727	Methotrexate	Methotrexate affects the expression of DNAJC6 mRNA	18502557
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DNAJC6 mRNA"	20188158
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAJC6 mRNA"	25510870
D010634	Phenobarbital	Phenobarbital results in decreased expression of DNAJC6 mRNA	19363144
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJC6 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of DNAJC6 mRNA	26272509
D012402	Rotenone	Rotenone results in decreased expression of DNAJC6 mRNA	23186747
D012834	Silver	Silver results in increased expression of DNAJC6 mRNA	26551752
D020123	Sirolimus	Sirolimus results in decreased expression of DNAJC6 mRNA	21865292
C017947	sodium arsenite	sodium arsenite results in increased expression of DNAJC6 mRNA	22714537
D012999	Soman	Soman results in decreased expression of DNAJC6 mRNA	19281266
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of DNAJC6 mRNA	26496021
C012589	trichostatin A	trichostatin A results in increased expression of DNAJC6 mRNA	24935251\|2670570
D014520	Urethane	Urethane results in increased expression of DNAJC6 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJC6 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of DNAJC6 mRNA	23179753\|2438349
D014640	Vancomycin	Vancomycin results in increased expression of DNAJC6 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of DNAJC6 gene	25560391
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of DNAJC6 mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004725	protein tyrosine phosphatase activity	-	IEA	-
GO:0017124	SH3 domain binding	-	IEA	-
GO:0030276	clathrin binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006898	receptor-mediated endocytosis	-	IBA	21873635
GO:0016191	synaptic vesicle uncoating	-	IBA	21873635
GO:0016191	synaptic vesicle uncoating	-	ISS	20160091
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IEA	-
GO:0061024	membrane organization	-	TAS	-
GO:0072318	clathrin coat disassembly	-	IBA	21873635
GO:0072583	clathrin-dependent endocytosis	-	IBA	21873635
GO:2000369	regulation of clathrin-dependent endocytosis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0014069	postsynaptic density	-	IBA	21873635
GO:0014069	postsynaptic density	-	IEA	-
GO:0031982	vesicle	-	IBA	21873635
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635

KEGG ID	KEGG Term
hsa04144	Endocytosis

Reactome ID	Reactome Term	Evidence
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-199992	trans-Golgi Network Vesicle Budding	TAS
R-HSA-421837	Clathrin derived vesicle budding	TAS
R-HSA-432720	Lysosome Vesicle Biogenesis	TAS
R-HSA-432722	Golgi Associated Vesicle Biogenesis	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-8856828	Clathrin-mediated endocytosis	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24550170	Smoking induces transcription of the heat shock protein system in the joints. (2014 Jul)	Ospelt C	Ann Rheum Dis