Gene: CDK1

983
CDC2|CDC28A|P34CDC2
cyclin dependent kinase 1
protein-coding
10q21.2
Ensembl:ENSG00000170312 MIM:116940 Vega:OTTHUMG00000018290 UniprotKB:P06493
NG_029877.1
PubMed|SNP Mapped
CD|ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.646e-1 (AD)  6.702e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2456778chr10:60792132 (GRCh38.p7)A>Tcocaine dependenceSNV(Single Nucleotide Variation)
rs2448363chr10:60790961 (GRCh38.p7)C>Tcocaine dependenceSNV(Single Nucleotide Variation)
rs744383chr10:60777020 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SETDB20.548
CKAP2L0.542
PTPRK0.539
TUBGCP30.535
PLAG10.533
ARL150.531
USP430.529
PIGL0.528
RHOBTB10.527
VPS13A0.527

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AQP5-0.298
PINLYP-0.294
PLA2G5-0.293
SIX3-0.292
BANF2-0.27
ZNF114-0.256
S100A1-0.255
NPPB-0.253
TBX5-0.25
VAX2-0.247

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02052Indirubin-3'-MonoximeSmall MoleculeExperimentalTarget
DB02116OlomoucineSmall Molecule101622-51-9ExperimentalTarget
DB02950HymenialdisineSmall MoleculeExperimentalTarget
DB03428SU9516Small MoleculeExperimentalTarget
DB03496AlvocidibSmall Molecule146426-40-6Experimental|InvestigationalTarget
DB04014AlsterpaulloneSmall MoleculeExperimentalTarget
DB05037AT7519Small Molecule-InvestigationalTarget
DB06195SeliciclibSmall Molecule186692-46-6InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CDK1 mRNA"26377693
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane inhibits the reaction [Cisplatin results in increased phosphorylation of CDK1 protein]"20195699
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CDK1 mRNA"22698814|2890350
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CDK1 mRNA]"22698814
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of CDK1 mRNA"21530604
C495172(19Z)-halichondramide(19Z)-halichondramide results in decreased expression of CDK1 protein23147639
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Doxorubicin] results in decreased phosphorylation of CDK1 protein"20826841
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of CDK1 protein"20826841
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK1 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDK1 mRNA"26988655
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDK1 protein"26988655
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]19038232
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]22230261
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein]22230261
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]22230261
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of CDK1 mRNA"20826375
C4881852-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]"26385184
C4881852-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]"26385184
C0445652-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide results in decreased activity of CDK1 protein15529313|1575432
C0445652-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide results in decreased expression of CDK1 protein modified form16142332
C0445652-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide results in increased expression of CDK1 protein15754328
C0445652-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide results in increased expression of CDK1 protein modified form16857806
C0445652-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide results in increased phosphorylation of CDK1 protein15529313|1575432
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CDK1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of CDK1 mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDK1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CDK1 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CDK1 protein23301080
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK1 mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of CDK1 mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDK1 mRNA"20816883
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CDK1 mRNA"23681119
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of CDK1 protein20469912
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of CDK1 protein20469912
C0702792'-cyano-2'-deoxyarabinofuranosylcytosine2'-cyano-2'-deoxyarabinofuranosylcytosine results in increased phosphorylation of CDK1 protein16061671
C5452392'-epi-2'-O-acetylthevetin B2'-epi-2'-O-acetylthevetin B results in decreased expression of CDK1 protein19874809
C0228302-methoxyestradiol2-methoxyestradiol results in decreased phosphorylation of CDK1 protein23967052
C0194992-nitrofluorene2-nitrofluorene results in increased expression of CDK1 mRNA15890375
C5467063-(3,4,5-trimethoxybenzylidene)-5-carboethoxyindolin-2-one"3-(3,4,5-trimethoxybenzylidene)-5-carboethoxyindolin-2-one results in decreased expression of CDK1 protein"19883635
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDK1 mRNA"23196670
C5000673-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol3-((5-(6-((3-chlorophenyl)amino)pyrazinyl)-3-pyridinyl)amino)-1-propanol binds to and results in decreased activity of CDK1 protein15771433
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CDK1 protein19477251
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CDK1 mRNA22841810
C5277933-methyl-9-(2-oxa-2lambda(5)-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro(5.5)undecane"3-methyl-9-(2-oxa-2lambda(5)-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro(5.5)undecane affects the phosphorylation of CDK1 protein"18176113
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CDK1 mRNA"25380136
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in decreased activity of CDK1 protein]17373649
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of CDK1 protein"24161432
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDK1 mRNA15890375
C4948984-oxofenretinide4-oxofenretinide results in decreased phosphorylation of CDK1 protein16540676
C5241355-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide"5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide inhibits the reaction [Chromium results in increased phosphorylation of CDK1 protein]"20089605
C5497535,7,3'-trihydroxy-3,4'-dimethoxyflavone"5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDK1 protein"21229608
C5805985-OH-BDE-475-OH-BDE-47 results in increased expression of CDK1 mRNA26988655
C5805985-OH-BDE-475-OH-BDE-47 results in increased expression of CDK1 protein26988655
C5762686-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide"6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog affects the phosphorylation of CDK1 protein"27720946
C5762686-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide"AKT1 protein affects the reaction [6-(3,4-dihydro-1H-isoquinolin-2-yl)-N-(6-methylpyridin-2-yl)nicotinamide analog affects the phosphorylation of CDK1 protein]"27720946
C4718436-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine results in decreased activity of CDK1 protein15958644
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased phosphorylation of and results in decreased expression of CDK1 protein"23274516
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"TP53 mutant form inhibits the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased phosphorylation of and results in decreased expression of CDK1 protein]"23274516
C5838836-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone"6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CDK1 protein"23212307
C5838836-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone"pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CDK1 protein]"23212307
C5319376-O-angeloylenolin6-O-angeloylenolin results in decreased expression of CDK1 protein21192922
C5319376-O-angeloylenolin6-O-angeloylenolin results in decreased expression of CDK1 protein modified form21192922
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of CDK1 protein26988655
C5591457-benzylamino-5-(2-(hydroxymethyl)propyl)amino-3-isopropyl-1(2)H-pyrazolo(4,3-d)pyrimidine"7-benzylamino-5-(2-(hydroxymethyl)propyl)amino-3-isopropyl-1(2)H-pyrazolo(4,3-d)pyrimidine results in decreased activity of CDK1 protein"21417417
C0548527-hydroxystaurosporine[7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 mRNA19223503
C0548527-hydroxystaurosporine[7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 protein15767555|1922350
C0548527-hydroxystaurosporine[7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of CDK1 protein15767555
C0548527-hydroxystaurosporine7-hydroxystaurosporine inhibits the reaction [erythritol anhydride results in increased expression of CDK1 protein modified form]25633853
D000082AcetaminophenAcetaminophen results in decreased expression of CDK1 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of CDK1 mRNA22230336
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sinularin results in decreased phosphorylation of CDK1 protein]28548367
D000111AcetylcysteineAcetylcysteine inhibits the reaction [erythritol anhydride results in increased expression of CDK1 protein]25633853
D020106AcrylamideAcrylamide results in increased expression of CDK1 mRNA28959563
C016601afimoxifeneafimoxifene results in increased expression of CDK1 mRNA19901195
C016601afimoxifeneCDK1 results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CDK1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CDK1 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDK1 mRNA15890375|2363061
C512484AG-012986AG-012986 results in decreased activity of CDK1 protein22095879
C430898AGN 194204AGN 194204 results in decreased expression of CDK1 protein15318936|2108096
C430898AGN 194204CREBBP protein inhibits the reaction [AGN 194204 results in decreased expression of CDK1 protein]21080969
C430898AGN 194204NCOA1 protein inhibits the reaction [AGN 194204 results in decreased expression of CDK1 protein]21080969
C000188alachloralachlor results in increased expression of CDK1 mRNA12419858
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein]22266097
C077990alvocidib[alvocidib co-treated with PBOX-6] results in decreased activity of CDK1 protein20206141
C077990alvocidibalvocidib results in decreased activity of CDK1 protein12517783|9427698
C077990alvocidibalvocidib results in decreased expression of CDK1 protein modified form16905211
C077990alvocidibalvocidib results in decreased activity of CDK1 protein11464216|2020614
D004999AmifostineAmifostine results in decreased phosphorylation of CDK1 protein16628227
D004999Amifostineolomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]16628227
D004999AmifostineTP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]16628227
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDK1 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CDK1 mRNA"22863853
D000872AnthocyaninsAnthocyanins promotes the reaction [CDK1 protein binds to CCNB1 protein]27444805
D000872AnthocyaninsAnthocyanins results in increased expression of and results in increased phosphorylation of CDK1 protein27444805
D047310ApigeninApigenin results in decreased expression of CDK1 protein26872304
D047310ApigeninApigenin results in increased phosphorylation of and results in decreased activity of CDK1 protein11322924
D001115ArecolineArecoline results in decreased activity of CDK1 protein22108589
D001115Arecoline[[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein22108589
C000228aristolochic acid Iaristolochic acid I results in decreased expression of CDK1 mRNA17483316
D034341Aristolochic AcidsAristolochic Acids results in increased expression of CDK1 mRNA19717638
D001151ArsenicArsenic results in increased expression of CDK1 mRNA20654705
D001151ArsenicArsenic results in increased expression of CDK1 protein25868784
D001151Arsenicsilybin inhibits the reaction [Arsenic results in increased expression of CDK1 protein]25868784
C006632arsenic trioxidearsenic trioxide affects the expression of CDK1 mRNA18088464
C006632arsenic trioxide[arsenic trioxide co-treated with Paclitaxel] results in increased activity of CDK1 protein19781537
C006632arsenic trioxide[arsenic trioxide co-treated with Paclitaxel] results in increased expression of CDK1 protein modified form19781537
C006632arsenic trioxidearsenic trioxide promotes the reaction [CDK1 protein binds to CDKN1A protein]10850458
C006632arsenic trioxidearsenic trioxide results in decreased activity of CDK1 protein10850458
C006632arsenic trioxidearsenic trioxide results in decreased expression of and results in increased phosphorylation of CDK1 protein10850458|2273017
C006632arsenic trioxidearsenic trioxide results in decreased expression of CDK1 protein modified form19825857
C006632arsenic trioxidearsenic trioxide results in increased expression of CDK1 mRNA20862710
C006632arsenic trioxidePTEN protein promotes the reaction [arsenic trioxide results in increased phosphorylation of CDK1 protein]22730174
C006632arsenic trioxidearsenic trioxide results in increased expression of and results in increased phosphorylation of CDK1 protein23337567
C015001arsenite4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in decreased activity of CDK1 protein]17373649
C015001arsenitearsenite results in decreased activity of CDK1 protein17373649
C015001arsenitearsenite results in decreased expression of CDK1 protein20083129
C015001arsenitearsenite results in decreased expression of CDK1 mRNA18929588
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of CDK1 protein modified form"21570478
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CDK1 protein]21621607
D001262AtenololAtenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA]9593584
D001280AtrazineAtrazine results in increased expression of CDK1 mRNA27655631
D001285AtropineAtropine results in increased expression of CDK1 mRNA17390078
D001285Atropine[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA17390078
C105832auraptenaurapten affects the expression of CDK1 mRNA23320178
D001374AzacitidineAzacitidine analog results in increased expression of CDK1 protein18324645
D001374Azacitidine[Azacitidine co-treated with Thalidomide] affects the expression of CDK1 mRNA18720364
D001379AzathioprineAzathioprine results in decreased expression of CDK1 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of CDK1 mRNA22323515
C006680baicaleinbaicalein results in decreased phosphorylation of CDK1 protein18025287
C006680baicaleinSB 203580 inhibits the reaction [baicalein results in decreased phosphorylation of CDK1 protein]18025287
C006680baicaleinwortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein]18025287
C487081belinostatbelinostat results in decreased expression of CDK1 mRNA19606018
D001554BenzeneBenzene analog results in increased phosphorylation of CDK1 protein15826604
D001554BenzeneBenzene results in increased expression of CDK1 protein modified form20850422
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CDK1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDK1 mRNA18164116
C047723benzophenonebenzophenone results in increased expression of CDK1 mRNA22584684
D001564Benzo(a)pyreneBenzo(a)pyrene affects the localization of CDK1 protein15837074
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDK115837074
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDK1 mRNA20064835|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDK1 protein modified form20850422
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDK1 mRNA19770486|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDK1 mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDK1 mRNA20061341
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of CDK1 mRNA25566086
C038328BEP protocolBEP protocol results in decreased expression of CDK1 mRNA18987330
D004958EstradiolEstradiol results in increased expression of CDK1 mRNA16474171|1831028
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of CDK1 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of CDK1 mRNA20826375|2521013
C044887beta-methylcholinebeta-methylcholine affects the expression of CDK1 mRNA21179406
C095105bexarotenebexarotene results in decreased expression of CDK1 protein19067706
C053541bicalutamidebicalutamide results in decreased expression of CDK1 mRNA15638997
D017438Bisphenol A-Glycidyl MethacrylateBisphenol A-Glycidyl Methacrylate results in decreased expression of CDK1 mRNA20673999
D017438Bisphenol A-Glycidyl MethacrylateBisphenol A-Glycidyl Methacrylate results in decreased expression of CDK1 protein20673999
D017438Bisphenol A-Glycidyl MethacrylateCAT protein inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in decreased expression of CDK1 mRNA]20673999
C006780bisphenol Abisphenol A results in decreased expression of CDK1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CDK1 mRNA16474171
C006780bisphenol Abisphenol A results in increased expression of CDK1 protein25130739
C006780bisphenol Abisphenol A results in increased expression of CDK1 mRNA20826375|2762328
C006780bisphenol Abisphenol A results in decreased expression of CDK1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CDK1 mRNA17553608
D000069286BortezomibBortezomib inhibits the reaction [docetaxel results in increased activity of CDK1 protein]14749476|1692882
D000069286BortezomibBortezomib results in decreased activity of CDK1 protein14749476
D000069286BortezomibBortezomib results in increased activity of CDK1 protein19074855
D000069286BortezomibBortezomib results in increased phosphorylation of CDK1 protein20367638
C046785bryostatin 1bryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein]10516758
D002065BuspironeBuspirone results in decreased expression of CDK1 mRNA24136188
D002083Butylated Hydroxyanisole[propylparaben co-treated with Butylated Hydroxyanisole] results in decreased expression of CDK1 mRNA25086368
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of CDK1 protein23535288
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CDK1 mRNA15003993
D002087ButyratesButyrates results in decreased activity of CDK1 protein16007142
D002087ButyratesButyrates results in decreased expression of CDK1 mRNA14674679
D002104CadmiumCadmium results in increased expression of CDK1 mRNA25543212
D002104CadmiumCadmium promotes the reaction [CDKN1A protein binds to CDK1 protein binds to CCNE1 protein]20839231
D002104CadmiumCadmium results in decreased expression of CDK1 protein16730872
C028031cadmium acetatecadmium acetate promotes the reaction [CDKN1A protein binds to CDK1 protein]20839231
C028031cadmium acetatecadmium acetate results in decreased activity of [CCNE1 protein binds to CDK1 protein]20839231
C028031cadmium acetatecadmium acetate results in decreased expression of CDK1 mRNA20839231
C028031cadmium acetatecadmium acetate results in decreased expression of CDK1 protein20839231
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CDK1 mRNA17961207
D019256Cadmium Chloride"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]"26385184
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDK1 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDK1 protein26385184
D019256Cadmium Chloridetyrphostin AG 1478 inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]26385184
D019256Cadmium ChlorideCadmium Chloride affects the expression of CDK1 mRNA29287790
D019256Cadmium ChlorideCadmium Chloride affects the expression of CDK1 protein29287790
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDK1 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CDK1 mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CDK1 protein16730872
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in decreased expression of CDK1 protein16085347
D002110CaffeineCaffeine inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]19038232
D002110CaffeineCaffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDK1 protein]15975956
D002110CaffeineCaffeine results in decreased phosphorylation of and results in increased activity of CDK1 protein11835680
D002110CaffeineCaffeine inhibits the reaction [Cisplatin results in increased expression of CDK1 protein]9098629
C553149camphorquinonecamphorquinone results in decreased expression of CDK1 mRNA26658076
C553149camphorquinonecamphorquinone results in decreased expression of CDK1 protein26658076
C081643candesartancandesartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of CDK1 protein]18314486
D002211CapsaicinCapsaicin results in increased expression of CDK1 mRNA20349343
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CDK1 mRNA17484886|2733941
D002392CatechinCatechin affects the phosphorylation of CDK1 protein15134381
C034221catecholcatechol results in decreased expression of CDK1 protein23535288
C034221catecholcatechol results in increased expression of CDK1 protein23535288
C495817CC-8490CC-8490 results in decreased expression of CDK1 mRNA15604281
D002509CephaloridineCephaloridine results in decreased expression of CDK1 mRNA18500788
D002699ChlorambucilChlorambucil analog results in increased phosphorylation of and results in decreased activity of CDK1 protein16861886
D002706ChlordanChlordan results in increased expression of CDK1 mRNA20403969
C035377chlorendic acidchlorendic acid results in increased expression of CDK1 mRNA22584684
D002737ChloropreneChloroprene results in increased expression of CDK1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDK1 mRNA20938992
D002857Chromium"5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide inhibits the reaction [Chromium results in increased phosphorylation of CDK1 protein]"20089605
D002857ChromiumChromium results in increased phosphorylation of CDK1 protein20089605
C074702chromium hexavalent ionAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CDK1 protein]21621607
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of CDK1 protein21621607
C039671ciglitazoneciglitazone results in decreased expression of CDK1 protein21080969
C039671ciglitazoneCREBBP protein inhibits the reaction [ciglitazone results in decreased expression of CDK1 protein]21080969
C039671ciglitazoneNCOA1 protein inhibits the reaction [ciglitazone results in decreased expression of CDK1 protein]21080969
D002939CiprofloxacinCiprofloxacin results in increased expression of CDK1 mRNA18512786
D002939CiprofloxacinCiprofloxacin results in increased expression of CDK1 protein18512786
D002953CitrininCitrinin results in decreased expression of CDK1 protein modified form20929984
D002994ClofibrateClofibrate results in decreased expression of CDK1 protein21080969
D002994ClofibrateCREBBP protein inhibits the reaction [Clofibrate results in decreased expression of CDK1 protein]21080969
D002994ClofibrateNCOA1 protein inhibits the reaction [Clofibrate results in decreased expression of CDK1 protein]21080969
D003022ClotrimazoleClotrimazole results in decreased expression of CDK120724915
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDK1 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CDK1 mRNA20971185
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CDK1 mRNA15467011
D003300CopperCopper results in decreased expression of CDK1 mRNA19497425
D003300CopperCopper results in increased expression of CDK1 mRNA22465980
C464760copper-1,10-phenanthroline"copper-1,10-phenanthroline results in decreased expression of CDK1 protein"24638265
D019327Copper SulfateCopper Sulfate results in decreased expression of CDK1 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of CDK1 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDK1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CDK1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CDK1 mRNA19167446
C038106cucurbitacin Icucurbitacin I results in decreased expression of CDK1 protein24858077
C029892cupric chloridecupric chloride results in decreased expression of CDK1 protein22699969
C030973cupric oxidecupric oxide results in decreased expression of CDK1 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of CDK1 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of CDK1 mRNA22258452
D003474CurcuminCurcumin results in decreased expression of CDK1 protein17148446|1940170
D003474CurcuminCurcumin results in decreased expression of CDK1 mRNA18299980
C057862cyanoginosin LRcyanoginosin LR results in increased phosphorylation of CDK1 protein26506538
D016572CyclosporineCyclosporine results in decreased expression of CDK1 mRNA20106945|2163298
D003571Cytochalasin BCytochalasin B results in decreased expression of CDK1 protein27640744
D000069439DasatinibDasatinib results in decreased expression of CDK1 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CDK1 mRNA24317228
C014347decitabinedecitabine results in increased phosphorylation of CDK1 protein19372550
C014347decitabinedecitabine results in increased expression of CDK1 mRNA27915011
C014347decitabine[decitabine co-treated with Hydroxamic Acids analog] results in decreased expression of CDK121445578
D013759DronabinolCDK1 inhibits the reaction [Dronabinol results in decreased expression of BIRC5 protein]16818634
D013759DronabinolCDK1 results in decreased susceptibility to Dronabinol16818634
D013759DronabinolDronabinol results in decreased expression of CDK1 mRNA18454173
D013759DronabinolDronabinol results in decreased expression of CDK1 protein16818634
D013759DronabinolDronabinol results in decreased phosphorylation of and results in increased activity of CDK1 protein16818634
D013759DronabinolDronabinol results in increased expression of CDK1 mRNA18163980
D013759DronabinolSR 144528 inhibits the reaction [Dronabinol results in decreased expression of CDK1 protein]16818634
D003703DemecolcineDemecolcine results in decreased expression of CDK1 mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of CDK1 mRNA23137833
D003907DexamethasoneDexamethasone results in decreased expression of CDK1 mRNA14618091
C028009diallyl disulfidediallyl disulfide results in decreased expression of CDK1 protein16691315
C042577diallyl trisulfidediallyl trisulfide affects the localization of CDK1 protein20143254
C042577diallyl trisulfidediallyl trisulfide promotes the reaction [CDK1 protein binds to CCNB1 protein]20143254
C042577diallyl trisulfidediallyl trisulfide results in decreased activity of [CDK1 protein binds to CCNB1 protein]20143254
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of and results in increased phosphorylation of CDK1 protein23754639
D003976DiazinonDiazinon affects the expression of CDK1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDK1 mRNA21266533
D002945Cisplatin"(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane inhibits the reaction [Cisplatin results in increased phosphorylation of CDK1 protein]"20195699
D002945CisplatinCDK1 results in decreased susceptibility to Cisplatin21849418
D002945CisplatinCisplatin affects the reaction [Piroxicam results in decreased expression of CDK1 mRNA]21858171
D002945CisplatinCisplatin results in decreased activity of [CCNB1 protein binds to CDK1 protein]21592546
D002945CisplatinCisplatin results in decreased expression of CDK1 mRNA21603599
D002945CisplatinCisplatin results in increased phosphorylation of CDK1 protein20195699|2159254
D002945CisplatinCaffeine inhibits the reaction [Cisplatin results in increased expression of CDK1 protein]9098629
D002945CisplatinCisplatin results in increased expression of CDK1 protein9098629
C000944dicrotophosdicrotophos results in decreased expression of CDK1 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CDK1 mRNA26924002
D004026DieldrinDieldrin affects the expression of CDK1 mRNA22546817
D004041Dietary FatsDietary Fats affects the expression of CDK1 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of CDK1 mRNA18042831|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDK1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDK1 mRNA17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDK1 protein19887370
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDK1 mRNA]17854601
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDK1 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 mRNA12616621
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 protein12616621
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 mRNA12616621
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 protein12616621
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDK1 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CDK1 mRNA15890375
C035318diethylthioureadiethylthiourea results in increased expression of CDK1 mRNA22584684
D004074DigitoxinDigitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]22037315
D004074DigitoxinDigitoxin analog results in decreased expression of CDK1 protein22037315
D004074DigitoxinDigitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]22037315
D004074DigitoxinDigitoxin results in decreased expression of CDK1 protein22037315
D002117CalcitriolCalcitriol results in decreased expression of CDK1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CDK1 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CDK1 mRNA15890375|2538013
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of CDK1 mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of CDK1 mRNA22302311
D004237DiuronDiuron results in increased expression of CDK1 mRNA21551480
C067311docetaxelBortezomib inhibits the reaction [docetaxel results in increased activity of CDK1 protein]14749476|1692882
C067311docetaxelCDK1 results in increased susceptibility to docetaxel16928825
C067311docetaxeldocetaxel results in increased activity of CDK1 protein14749476|1692882
D004317Doxorubicin"[2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Doxorubicin] results in decreased phosphorylation of CDK1 protein"20826841
D004317DoxorubicinCDC25C protein inhibits the reaction [Doxorubicin results in increased phosphorylation of CDK1 protein]19074854
D004317DoxorubicinCDK1 protein affects the susceptibility to Doxorubicin16036217|1621774
D004317DoxorubicinDoxorubicin affects the activity of CDK1 protein16036217
D004317DoxorubicinDoxorubicin promotes the reaction [RBL2 protein binds to CDK1 promoter]16537896
D004317DoxorubicinDoxorubicin results in decreased expression of CDK1 mRNA15205334
D004317DoxorubicinDoxorubicin results in decreased expression of CDK1 protein15870702
D004317DoxorubicinDoxorubicin results in increased phosphorylation of and results in decreased activity of CDK1 protein15141020|1732027
D004317DoxorubicinDoxorubicin results in increased phosphorylation of CDK1 protein19074854
D004317DoxorubicinGo 6976 inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of CDK1 protein]17320279
D004317DoxorubicinDoxorubicin results in increased phosphorylation of CDK1 protein15861398
D004317DoxorubicinDoxorubicin results in decreased expression of CDK1 protein15124910
D004610Ellagic AcidEllagic Acid results in decreased expression of CDK1 protein23554011
C034192ellipticineellipticine results in decreased expression of and results in increased phosphorylation of CDK1 protein16027529
C007366erythritol anhydride7-hydroxystaurosporine inhibits the reaction [erythritol anhydride results in increased expression of CDK1 protein modified form]25633853
C007366erythritol anhydrideAcetylcysteine inhibits the reaction [erythritol anhydride results in increased expression of CDK1 protein]25633853
C007366erythritol anhydrideCHEK1 protein promotes the reaction [erythritol anhydride results in increased expression of CDK1 protein modified form]25633853
C007366erythritol anhydrideerythritol anhydride results in increased expression of CDK1 protein25633853
C007366erythritol anhydrideerythritol anhydride results in increased expression of CDK1 protein modified form25633853
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of CDK1 mRNA24412560
D004918Erythromycin EstolateErythromycin Estolate results in increased expression of CDK1 mRNA24412560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CDK1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDK1 mRNA12072388|1617478
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDK1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CDK1 mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDK1 mRNA15576828|1617478
C093323farnesylthiosalicylic acidfarnesylthiosalicylic acid results in decreased phosphorylation of CDK1 protein16780807
D005273FenbendazoleFenbendazole results in increased expression of CDK1 mRNA23411599
D005273FenbendazoleFenbendazole results in increased expression of CDK1 protein23411599
C082360fipronilfipronil results in increased expression of CDK1 mRNA23962444
C017875fisetinfisetin results in decreased expression of CDK1 protein28181380
C012976flumequine"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of CDK1 mRNA"23681119
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of CDK1 mRNA19167416|2258468
D005472FluorouracilFluorouracil affects the expression of CDK1 mRNA16557594
D005472FluorouracilFluorouracil results in decreased expression of CDK1 mRNA15205334|1703926
D005472FluorouracilFluorouracil results in increased expression of CDK1 mRNA15152939
D005472Fluorouracil[Leucovorin co-treated with Fluorouracil] results in increased expression of CDK1 mRNA15342418
D005472FluorouracilFluorouracil results in decreased expression of CDK1 mRNA26272751
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CDK1 mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDK1 mRNA20938992
D002955Leucovorin[Leucovorin co-treated with Fluorouracil] results in increased expression of CDK1 mRNA15342418
C058728fosbretabulinfosbretabulin analog results in increased phosphorylation of and results in decreased expression of CDK1 protein25529822
C070081fulvestrant[fulvestrant co-treated with Sirolimus] results in decreased expression of CDK1 mRNA19016759
C070081fulvestrantfulvestrant results in decreased expression of CDK1 mRNA19016759
C039281furanfuran results in increased expression of CDK1 mRNA25539665
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in decreased expression of CDK1 protein15318936
D019833GenisteinGenistein affects the expression of CDK1 mRNA18214933
D019833Genistein2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]19038232
D019833GenisteinCaffeine inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]19038232
D019833GenisteinGenistein affects the expression of CDK1 mRNA18847459
D019833GenisteinGenistein results in decreased phosphorylation of CDK1 protein10601582
D019833GenisteinGenistein results in increased expression of CDK1 mRNA16474171
D019833GenisteinGenistein results in increased phosphorylation of and results in decreased activity of CDK1 protein11322924
D019833GenisteinGenistein results in increased phosphorylation of CDK1 protein19038232
D019833GenisteinU 0126 inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]19038232
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]26577051
C007845gingerolgingerol results in decreased expression of CDK1 mRNA28249781
D005944GlucosamineGlucosamine results in decreased expression of CDK1 mRNA17109745
C010974glyphosateglyphosate affects the phosphorylation of CDK1 protein15375296
C081021Go 6976Go 6976 inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of CDK1 protein]17320279
C081021Go 6976Go 6976 inhibits the reaction [xanthatin results in increased phosphorylation of CDK1 protein]29074359
C081021Go 6976Go 6976 results in decreased phosphorylation of and results in increased activity of CDK1 protein17320279
D006046GoldGold results in decreased expression of CDK1 mRNA25523186
C103280goniothalamingoniothalamin results in decreased expression of CDK1 mRNA26522230
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CDK1 mRNA]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] inhibits the reaction [HRAS protein results in increased expression of CDK1 protein]22473992
C479979GW0742[GW0742 binds to and results in increased activity of PPARD protein] which results in decreased expression of CDK1 protein22473992
D006247HarmineHarmine results in increased expression of CDK1 mRNA25751815
D006247HarmineHarmine results in increased expression of CDK1 protein25751815
C001330hellebrigeninhellebrigenin results in increased phosphorylation of CDK1 protein24954031
D006540HerbicidesHerbicides results in decreased activity of CDK1 protein11896679
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde affects the expression of CDK1 mRNA22302311
D017313FenretinideFenretinide results in decreased expression of CDK1 mRNA16671099
D017313FenretinideFenretinide results in increased expression of CDK1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CDK1 mRNA20044591|2117940
D006877Hydroxamic Acids[decitabine co-treated with Hydroxamic Acids analog] results in decreased expression of CDK121445578
D000068877Imatinib Mesylate[Imatinib Mesylate co-treated with tetraarsenic tetrasulfide] results in decreased expression of CDK1 mRNA19208803
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of CDK1 mRNA18190601|1920880
C027185indirubinindirubin results in decreased expression of CDK1 mRNA15056799
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CDK1 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of CDK1 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of CDK1 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of CDK1 mRNA20097248
D007545IsoproterenolAtenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA]9593584
D007545IsoproterenolIsoproterenol results in increased expression of CDK1 mRNA9593584
D007545IsoproterenolIsoproterenol results in increased expression of CDK1 protein9593584
C545474JAI-51JAI-51 results in increased expression of CDK1 protein24134853
C544151jinfukangjinfukang results in increased expression of CDK1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of CDK1 mRNA12832151
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDK1 mRNA24796395|2596192
C410337K 7174K 7174 results in decreased expression of CDK1 mRNA24086573
C006552kaempferolkaempferol results in increased phosphorylation of and results in decreased activity of CDK1 protein11322924
C524169kaempferol 7-O-glucosidekaempferol 7-O-glucoside results in decreased expression of CDK1 mRNA18343026
C524169kaempferol 7-O-glucosidekaempferol 7-O-glucoside results in decreased expression of CDK1 protein18343026
D007649KetamineKetamine results in decreased expression of CDK1 mRNA20080153
D007840LatexLatex analog results in increased expression of CDK1 mRNA24768652
C045463leflunomideleflunomide results in decreased expression of CDK1 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of CDK1 mRNA24136188
C038753leptomycin Bleptomycin B results in decreased expression of CDK1 mRNA20803015
D064704LevofloxacinLevofloxacin results in decreased expression of CDK1 mRNA24136188
C541528licochalcone Blicochalcone B results in decreased expression of CDK1 mRNA24384411
C008281limonenelimonene results in increased expression of CDK1 mRNA12815608
D008070LipopolysaccharidesLipopolysaccharides affects the expression of CDK1 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of CDK1 mRNA]28070326
C506643liposomal doxorubicinliposomal doxorubicin results in decreased expression of CDK1 protein27923599
C000589248LL-202LL-202 affects the phosphorylation of and results in decreased expression of CDK1 protein24752227
C581034longikaurin Alongikaurin A results in decreased expression of CDK1 protein28801140
D008154LucanthoneLucanthone results in decreased expression of CDK1 mRNA21148553
D047311LuteolinLuteolin results in decreased expression of CDK1 protein22926442
C015329lycopenelycopene results in decreased expression of CDK1 protein17337101
C005095malachite green[Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 mRNA12616621
C005095malachite green[Diethylnitrosamine co-treated with malachite green] results in increased expression of CDK1 protein12616621
C013592mangiferinmangiferin results in increased expression of CDK1 mRNA20518311
D008466MechlorethamineMechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]8463339
D008466MechlorethamineMechlorethamine results in decreased activity of CDK1 protein8463339
D008466MechlorethamineMechlorethamine results in increased stability of CDK1 protein modified form8463339
D008466MechlorethaminePentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]8463339
D008550MelatoninMelatonin results in decreased expression of CDK1 mRNA21108658
D008550MelatoninMelatonin results in decreased expression of CDK1 protein21108658
D008627Mercuric ChlorideMercuric Chloride affects the expression of CDK1 mRNA20353558
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of CDK1 mRNA16507785
C005108metanil yellow[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 mRNA12616621
C005108metanil yellow[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 protein12616621
D008694MethamphetamineMethamphetamine results in decreased expression of CDK1 mRNA28341135
D008694MethamphetamineMethamphetamine results in decreased expression of CDK1 protein28341135
D008694MethamphetamineMethamphetamine results in increased expression of CDK1 mRNA15644446
D008701MethapyrileneMethapyrilene results in increased expression of CDK1 mRNA15890375|2258468
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDK1 mRNA20938992
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CDK1 mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of CDK1 mRNA21678067|2465727
C005223methyleugenolmethyleugenol results in increased expression of CDK1 protein23411599
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CDK1 mRNA20061341
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDK1 mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of CDK115870882
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of CDK1 protein18593901
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of CDK1 mRNA16525678
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CDK1 mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CDK1 mRNA16026605
C033069methyl salicylatemethyl salicylate affects the expression of CDK1 mRNA22302311
C008493methylselenic acidHSPA5 protein affects the reaction [methylselenic acid results in decreased expression of CDK1 protein]16205645
C008493methylselenic acidmethylselenic acid results in decreased expression of CDK1 mRNA11830524|1251777
C008493methylselenic acidmethylselenic acid results in decreased expression of CDK1 protein11830524|1620564
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]26577051
D015735MifepristoneMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein]22266097
D015735MifepristoneMifepristone results in decreased expression of CDK1 protein17545545
D015735MifepristoneMifepristone results in increased expression of CDK1 mRNA17584828
D016685MitomycinMitomycin results in decreased expression of CDK1 mRNA25270620
C549567MK-1775MK-1775 results in decreased phosphorylation of CDK1 protein25125259
C070571ML 7ML 7 inhibits the reaction [EGF protein results in increased expression of CDK1 protein]16799973
C523184mocetinostatmocetinostat results in decreased expression of CDK1 mRNA26378038
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CDK1 mRNA26924002
C008548morinmorin results in decreased expression of CDK1 mRNA28689916
D009151Mustard GasMustard Gas results in decreased expression of CDK1 mRNA25102026
D009151Mustard GasMustard Gas results in increased phosphorylation of CDK1 protein25448276
D009151Mustard GasPF 00477736 inhibits the reaction [Mustard Gas results in increased phosphorylation of CDK1 protein]25448276
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CDK1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CDK1 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of CDK1 mRNA18978301
C031721naphthalenenaphthalene analog results in increased expression of CDK1 mRNA24976557
D009532NickelNickel results in increased expression of CDK1 mRNA25583101
C017557nickel subsulfidenickel subsulfide results in increased expression of CDK1 mRNA24952340
C012655nimesulidenimesulide results in decreased expression of CDK1 mRNA24136188
D009599NitroprussideNitroprusside results in decreased phosphorylation of CDK1 protein14988404
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of CDK1 mRNA17616710
D015739NocodazoleNocodazole analog results in increased expression of CDK1 protein28412508
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CDK1 mRNA20971185
C466913NU2058NU2058 results in decreased activity of CDK1 protein17599054
C025589ochratoxin A2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]22230261
C025589ochratoxin A2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein]22230261
C025589ochratoxin A2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]22230261
C025589ochratoxin AMAPK14 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]22230261
C025589ochratoxin AMAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]22230261
C025589ochratoxin AMAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]22230261
C025589ochratoxin AMAPK1 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]22230261
C025589ochratoxin AMAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein]22230261
C025589ochratoxin AMAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]22230261
C025589ochratoxin Aochratoxin A inhibits the reaction [CCNB1 protein binds to CDK1 protein]20060447
C025589ochratoxin Aochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]22230261
C025589ochratoxin Aochratoxin A results in decreased expression of CDK1 mRNA20060447
C025589ochratoxin Aochratoxin A results in decreased expression of CDK1 protein20060447|2223026
C025589ochratoxin Aochratoxin A results in decreased expression of CDK1 protein modified form22230261
C025589ochratoxin ASB 203580 inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]22230261
C025589ochratoxin ASB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein]22230261
C025589ochratoxin ASB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]22230261
C025589ochratoxin Aochratoxin A results in increased expression of CDK1 mRNA25636497
C025589ochratoxin ATRP53 gene mutant form promotes the reaction [ochratoxin A results in increased expression of CDK1 mRNA]25636497
C025589ochratoxin Aochratoxin A results in increased expression of CDK1 mRNA19237604|1971763
C025589ochratoxin Aochratoxin A results in increased expression of CDK1 protein19237604
D019319Okadaic AcidOkadaic Acid results in decreased expression of CDK1 mRNA21512803
C090046olomoucineolomoucine inhibits the reaction [TP53 protein promotes the reaction [Amifostine results in decreased phosphorylation of CDK1 protein]]16628227
C090046olomoucineolomoucine inhibits the reaction [TP53 results in decreased phosphorylation of CDK1 protein]16628227
C507134ON 01910ON 01910 results in increased expression of CDK1 protein25472472
C016340o,p'-DDT"o,p'-DDT results in increased expression of CDK1 mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of CDK1 mRNA"24096037
C030110oxaliplatinoxaliplatin results in decreased expression of CDK1 protein16024531
C030110oxaliplatinoxaliplatin results in increased expression of CDK1 protein15204521
C030110oxaliplatinoxaliplatin results in increased expression of CDK1 protein modified form19735649
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CDK1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of CDK1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of CDK1 mRNA26516004
D010100OxygenOxygen deficiency results in increased expression of CDK1 protein26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of CDK1 protein]26476374
D010126OzoneOzone results in decreased expression of CDK1 mRNA24336422
D010126OzoneOzone results in increased expression of CDK1 mRNA12763052|1955522
D017239Paclitaxel[arsenic trioxide co-treated with Paclitaxel] results in increased activity of CDK1 protein19781537
D017239Paclitaxel[arsenic trioxide co-treated with Paclitaxel] results in increased expression of CDK1 protein modified form19781537
D017239Paclitaxelbryostatin 1 inhibits the reaction [Paclitaxel results in increased activity of CDK1 protein]10516758
D017239PaclitaxelPaclitaxel results in decreased expression of CDK1 mRNA18058816
D017239PaclitaxelPaclitaxel results in increased activity of CDK1 protein10516758
D017239Paclitaxel[pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein18516295
C500026palbociclibpalbociclib analog results in decreased expression of CDK1 mRNA15542782
C500026palbociclibpalbociclib results in decreased expression of CDK1 mRNA22869556
C500026palbociclibpalbociclib results in decreased expression of CDK1 mRNA24606660
D000073878Palm OilPalm Oil affects the expression of CDK1 mRNA19680557
D000073878Palm OilPalm Oil results in increased expression of CDK1 mRNA18042831
C482884panduratin Apanduratin A results in decreased expression of CDK1 protein16497706
D010278Parathion[Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA17390078
D010278ParathionParathion results in increased expression of CDK1 mRNA17390078
D052638Particulate MatterParticulate Matter results in decreased expression of CDK1 mRNA28366736
D052638Particulate MatterParticulate Matter results in increased expression of CDK1 protein modified form20850422
C418868PBOX-6[alvocidib co-treated with PBOX-6] results in decreased activity of CDK1 protein20206141
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK1 mRNA"25510870
C008776pelargonic acidpelargonic acid affects the expression of CDK1 mRNA22302311
D010431PentoxifyllinePentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]]8463339
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CDK1 mRNA26300304
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CDK1 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CDK1 protein26879310
C532366PF 00477736PF 00477736 inhibits the reaction [Mustard Gas results in increased phosphorylation of CDK1 protein]25448276
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of CDK1 protein23535288
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDK1 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CDK1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of CDK1 mRNA19482888|2309116
D010634PhenobarbitalPhenobarbital results in increased expression of CDK1 mRNA19162173
D010672PhenytoinPhenytoin results in decreased expression of CDK1 mRNA26272751
D009764o-Phthalaldehydeo-Phthalaldehyde affects the expression of CDK1 mRNA22302311
D048789PhytoestrogensPhytoestrogens results in increased expression of CDK1 mRNA18310284
C415032picropodophyllinpicropodophyllin results in decreased activity of CDK1 protein16166596
C121565pifithrin[pifithrin co-treated with Paclitaxel] results in decreased phosphorylation of CDK1 protein18516295
C121565pifithrinpifithrin results in increased expression of CDK1 protein16620711
C121565pifithrinpifithrin results in increased phosphorylation of CDK1 protein16620711
D010862PilocarpinePilocarpine results in increased expression of CDK1 mRNA14656328
C008922piperinepiperine inhibits the reaction [IL2 protein results in increased expression of CDK1 protein]25655587
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of CDK1 mRNA15890375
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of CDK1 protein23411599
C027260pirarubicinpirarubicin affects the phosphorylation of and results in decreased activity of CDK1 protein22580740
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of CDK1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of CDK1 mRNA17426115
C006253pirinixic acidpirinixic acid results in decreased phosphorylation of CDK1 protein19748123
C006253pirinixic acidpirinixic acid results in increased expression of CDK1 mRNA16377806|1795077
C006253pirinixic acidpirinixic acid results in increased expression of CDK1 protein17483499|1917653
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of CDK1 protein]17483499
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of CDK1 mRNA]17950772
C006253pirinixic acidRXRA protein promotes the reaction [pirinixic acid results in increased expression of CDK1 mRNA]19176532
C006253pirinixic acidRXRA protein promotes the reaction [pirinixic acid results in increased expression of CDK1 protein]19176532
C006253pirinixic acidpirinixic acid results in increased expression of CDK1 mRNA15890375
D010894PiroxicamCisplatin affects the reaction [Piroxicam results in decreased expression of CDK1 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of CDK1 mRNA21858171
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of CDK1 mRNA]28070326
D010936Plant ExtractsPlant Extracts results in decreased expression of CDK1 mRNA25051199
D010936Plant ExtractsPlant Extracts results in decreased expression of CDK1 protein26122529
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of CDK1 mRNA16474171
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of CDK1 mRNA23147375
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of CDK1 mRNA24583197
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CDK1 mRNA27989595
C443641poly(propyleneimine)poly(propyleneimine) analog results in decreased expression of CDK1 mRNA16308212
C019536potassium bromatepotassium bromate results in increased phosphorylation of CDK1 protein20067818
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CDK1 mRNA23628323
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CDK1 mRNA26348139
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CDK1 protein26348139
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione results in decreased expression of CDK1 protein"17475222
D011285Pregnenolone CarbonitrileNR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CDK1 mRNA]22698814
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CDK1 mRNA22698814
C017674procyanidinprocyanidin results in decreased phosphorylation of CDK1 protein15827326
D011374ProgesteroneProgesterone affects the expression of CDK1 mRNA23012394
D011374ProgesteroneProgesterone results in decreased expression of CDK1 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of CDK1 mRNA18070364
D011374ProgesteroneProgesterone results in decreased expression of CDK1 mRNA20726854
D011374ProgesteroneProgesterone results in decreased phosphorylation of CDK1 protein17055699
C045950propiconazolepropiconazole results in increased expression of CDK1 mRNA21278054
C005556propionaldehydepropionaldehyde results in decreased expression of CDK1 mRNA26079696
D015742PropofolPropofol results in decreased expression of CDK1 protein28804952
C006068propylparaben[propylparaben co-treated with Butylated Hydroxyanisole] results in decreased expression of CDK1 mRNA25086368
C006068propylparabenpropylparaben results in decreased expression of CDK1 mRNA25086368
D011441PropylthiouracilPropylthiouracil results in increased expression of CDK1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CDK1 mRNA27029645
C432165pyrazolanthrone"pyrazolanthrone inhibits the reaction [6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone results in increased expression of CDK1 protein]"23212307
C432165pyrazolanthronepyrazolanthrone results in decreased expression of CDK1 protein18593901
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of CDK1 mRNA"21152443
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of CDK1 mRNA"21152443
D011794QuercetinQuercetin results in decreased expression of CDK1 mRNA14715546|2372791
D011794QuercetinQuercetin results in decreased expression of CDK1 protein16049707|1900955
D011794QuercetinQuercetin affects the expression of CDK115067354
D011794QuercetinQuercetin affects the phosphorylation of CDK1 protein15067354
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of CDK1 protein]26476374
D011804QuinolinesQuinolines analog results in increased phosphorylation of CDK1 protein15826604
D017382Reactive Oxygen SpeciesReactive Oxygen Species results in decreased expression of CDK1 mRNA25800948
C059514resveratrolresveratrol results in decreased expression of CDK1 mRNA24314921
C059514resveratrolCaffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDK1 protein]15975956
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CDK1 mRNA19167446
C059514resveratrolresveratrol affects the activity of [CCNB1 protein co-treated with CDK1 protein]12392819
C059514resveratrolresveratrol affects the expression of CDK1 protein12392819
C059514resveratrolresveratrol results in decreased activity of [CCNB1 protein binds to CDK1 protein]17050787
C059514resveratrolresveratrol results in decreased expression of CDK1 mRNA15767336|2313783
C059514resveratrolresveratrol results in decreased expression of CDK1 protein17050787|1808983
C059514resveratrolresveratrol results in increased expression of CDK1 mRNA19167446
C059514resveratrolresveratrol results in increased expression of CDK1 protein11577002
C059514resveratrolresveratrol results in increased phosphorylation of CDK1 protein15975956|2352218
C059514resveratrol[temozolomide co-treated with resveratrol] results in decreased phosphorylation of CDK1 protein23522185
C059514resveratrolresveratrol affects the phosphorylation of CDK1 protein15134381
C059514resveratrolCDK1 protein mutant form results in decreased susceptibility to resveratrol15975956
C540615retigeric acid Bretigeric acid B results in decreased expression of CDK1 protein modified form20692244
D012176RetinoidsRetinoids results in decreased expression of CDK1 protein19067706
C104586roscovitineroscovitine results in decreased activity of CDK1 protein15231455|1531766
D012439SaccharinSaccharin results in increased expression of CDK1 mRNA26272751
C093642SB 203580SB 203580 inhibits the reaction [baicalein results in decreased phosphorylation of CDK1 protein]18025287
C093642SB 203580SB 203580 inhibits the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]22230261
C093642SB 203580SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein]22230261
C093642SB 203580SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDK1 protein modified form]22230261
C499814Scutellaria baicalensis extractScutellaria baicalensis extract results in decreased expression of and results in decreased activity of CDK1 protein17516867
D012643SeleniumSelenium deficiency results in decreased expression of CDK1 mRNA11925459
D012715Sesame OilSesame Oil results in decreased expression of CDK1 mRNA29191790
D017655Silicon CompoundsSilicon Compounds results in decreased expression of CDK1 protein23620807
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CDK1 mRNA23806026
D012834SilverNFE2L2 protein affects the reaction [Silver results in increased phosphorylation of CDK1 protein]22546375
D012834SilverSilver results in increased phosphorylation of CDK1 protein22546375
D012835Silver NitrateSilver Nitrate analog affects the expression of CDK1 mRNA22831968
C440975silybinsilybin inhibits the reaction [Arsenic results in increased expression of CDK1 protein]25868784
D019821SimvastatinSimvastatin results in decreased expression of CDK1 mRNA17428261|2087809
D019821SimvastatinSimvastatin results in decreased expression of CDK1 protein20878096
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]26577051
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein]26577051
D019821SimvastatinSimvastatin results in decreased expression of CDK1 protein26577051
C574383sinularinAcetylcysteine inhibits the reaction [sinularin results in decreased phosphorylation of CDK1 protein]28548367
C574383sinularinsinularin results in decreased phosphorylation of CDK1 protein28548367
D020123Sirolimus[7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 mRNA19223503
D020123Sirolimus[7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 protein15767555|1922350
D020123Sirolimus[7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of CDK1 protein15767555
D020123Sirolimus[fulvestrant co-treated with Sirolimus] results in decreased expression of CDK1 mRNA19016759
D020123SirolimusSirolimus results in decreased expression of CDK18419408
D020123SirolimusSirolimus inhibits the reaction [IL2 protein results in increased expression of CDK1 mRNA]11355896
D020123SirolimusSirolimus results in decreased activity of CDK1 protein7503980
D020123SirolimusSirolimus results in decreased expression of CDK1 mRNA19922502
D020123SirolimusSirolimus results in decreased expression of CDK1 protein19922502
D020123SirolimusSirolimus results in decreased activity of CDK1 protein7532117
C110881S-nitro-N-acetylpenicillamineS-nitro-N-acetylpenicillamine results in decreased phosphorylation of CDK1 protein14988404
C017947sodium arsenitesodium arsenite affects the phosphorylation of CDK1 protein18501396
C017947sodium arsenitesodium arsenite results in increased expression of and results in increased phosphorylation of CDK1 protein16614167
C017947sodium arsenitesodium arsenite results in increased expression of CDK1 mRNA12016162
C017947sodium arseniteTP53 protein inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of CDK1 protein]16614167
C017947sodium arsenitesodium arsenite results in decreased expression of CDK1 mRNA16014739
C017947sodium arsenitesodium arsenite results in decreased expression of CDK1 protein16338954
C017947sodium arsenitesodium arsenite results in decreased expression of CDK1 protein modified form16338954
C017947sodium arseniteTretinoin inhibits the reaction [sodium arsenite results in decreased expression of CDK1 protein]21964460
C016104sodium bichromatesodium bichromate results in increased expression of CDK1 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of CDK1 mRNA22561333
D012999SomanSoman results in increased expression of CDK1 mRNA19281266
C471405sorafenibsorafenib results in decreased expression of CDK1 protein19139124
C561322sparstolonin Bsparstolonin B results in decreased expression of CDK1 mRNA23940584
C075117squalestatin 1squalestatin 1 results in decreased expression of CDK1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of CDK1 mRNA27225895
C110630SR 144528SR 144528 inhibits the reaction [Dronabinol results in decreased expression of CDK1 protein]16818634
D013241SterigmatocystinMLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDK1 protein]23296099
D013241SterigmatocystinMLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDK1 protein modified form]23296099
D013241SterigmatocystinSterigmatocystin results in decreased expression of [CCNB1 protein binds to CDK1 protein]23296099
D013241SterigmatocystinSterigmatocystin results in increased expression of CDK1 mRNA23296099
D013241SterigmatocystinSterigmatocystin results in increased expression of CDK1 protein23296099
D013241SterigmatocystinSterigmatocystin results in increased expression of CDK1 protein modified form23296099
D013412SulfadimethoxineSulfadimethoxine results in increased expression of CDK1 protein23535288
D013449SulfonamidesSulfonamides analog results in increased phosphorylation of CDK1 protein15826604
D013467SulindacSulindac results in decreased expression of CDK1 mRNA16273229
D014284TriiodothyronineTriiodothyronine results in increased expression of CDK1 mRNA17399805|1740354
C013698tallowtallow affects the expression of CDK1 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of CDK1 mRNA14699072
D013629TamoxifenTamoxifen results in decreased expression of CDK1 mRNA15604281
D013629TamoxifenTamoxifen affects the expression of CDK1 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of CDK1 mRNA12841865
C112765tanespimycin[tanespimycin co-treated with NQO1 protein] results in decreased expression of CDK1 protein21156818
C047246temozolomideAKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of and results in decreased activity of CDK1 protein]15930307
C047246temozolomidetemozolomide affects the phosphorylation of CDK1 protein23522185
C047246temozolomide[temozolomide co-treated with resveratrol] results in decreased phosphorylation of CDK1 protein23522185
C047246temozolomidetemozolomide results in increased phosphorylation of and results in decreased activity of CDK1 protein15930307
C076852terameprocolterameprocol results in decreased expression of CDK1 mRNA15958646
C076852terameprocolterameprocol results in decreased expression of CDK1 protein15958646
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CDK1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CDK1 mRNA21592394
C004648testosterone enanthatetestosterone enanthate affects the expression of CDK1 mRNA17440010
C534735tetraarsenic tetrasulfide[Imatinib Mesylate co-treated with tetraarsenic tetrasulfide] results in decreased expression of CDK1 mRNA19208803
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of CDK1 mRNA26988606
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CDK1 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDK1 mRNA16714409
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein]22266097
D013749TetrachlorodibenzodioxinMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein]22266097
D013749TetrachlorodibenzodioxinPGR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein]22266097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDK1 mRNA15056799|1990119
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDK1 mRNA21496263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein22266097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDK1 protein9707505
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDK1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDK1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDK1 mRNA15667827|1794274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein23298284
D013755Tetradecanoylphorbol AcetatePPARD protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDK1 mRNA]10866668
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CDK1 mRNA10866668
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CDK1 mRNA25613284
D013792Thalidomide[Azacitidine co-treated with Thalidomide] affects the expression of CDK1 mRNA18720364
D019284ThapsigarginThapsigargin results in decreased expression of CDK1 mRNA22378314
D013849ThimerosalThimerosal results in increased expression of CDK1 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of CDK1 mRNA23411599
D013853ThioacetamideThioacetamide results in increased expression of CDK1 protein23411599
D013974ThyroxineThyroxine results in increased expression of CDK1 mRNA17403546
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in decreased expression of CDK1 mRNA23825117
C009495titanium dioxidetitanium dioxide results in increased expression of CDK1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CDK1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CDK1 mRNA28111298
D024505TocopherolsTocopherols results in increased expression of CDK1 mRNA17056531
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CDK1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CDK1 mRNA25729387
C099150trabectedintrabectedin results in increased expression of CDK1 mRNA12154027
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of CDK1 mRNA"17951470
D014212TretinoinCDK1 protein affects the reaction [Tretinoin results in increased expression of SCT mRNA]16888198
D014212TretinoinTretinoin results in decreased expression of CDK1 mRNA17138961
D014212TretinoinTretinoin results in decreased expression of CDK1 protein16517207
D014212TretinoinTretinoin inhibits the reaction [sodium arsenite results in decreased expression of CDK1 protein]21964460
D014241TrichloroethyleneTrichloroethylene results in increased expression of CDK1 mRNA25549359
D014241TrichloroethyleneTrichloroethylene results in increased expression of CDK1 mRNA17905399
C012589trichostatin Atrichostatin A results in decreased expression of CDK1 mRNA19606018|2377000
C020946triethylene glycol dimethacrylatetriethylene glycol dimethacrylate results in decreased expression of CDK1 mRNA22486746
C020946triethylene glycol dimethacrylatetriethylene glycol dimethacrylate results in decreased expression of CDK1 protein22486746
C015559trimellitic anhydridetrimellitic anhydride affects the expression of CDK1 mRNA22302311
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CDK1 mRNA19042947
C001899triptolidetriptolide results in increased expression of CDK1 mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDK1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CDK1 mRNA19140230
C057693troglitazonetroglitazone results in decreased expression of CDK1 protein12595159
C080163trovafloxacintrovafloxacin results in decreased expression of CDK1 mRNA24136188
D014415TunicamycinTunicamycin results in decreased expression of CDK1 mRNA22378314
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]26385184
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [EGF protein results in increased expression of CDK1 protein]26385184
C113580U 0126U 0126 inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]19038232
D014520UrethaneUrethane results in decreased expression of CDK1 mRNA28818685
D014747VinblastineCDK1 protein affects the susceptibility to Vinblastine16217747
D014750VincristineVincristine results in decreased expression of CDK1 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of CDK1 mRNA26682919
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in decreased expression of CDK1 mRNA23825117
D014800VitalliumVitallium analog results in decreased expression of CDK1 mRNA23825117
C111237vorinostatvorinostat results in decreased expression of CDK1 protein19875160
C111237vorinostatvorinostat results in increased expression of CDK1 mRNA27188386
C009687wortmannin"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]"26385184
C009687wortmannin"[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]"26385184
C009687wortmanninwortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein]18025287
C022186xanthatinGo 6976 inhibits the reaction [xanthatin results in increased phosphorylation of CDK1 protein]29074359
C022186xanthatinxanthatin results in decreased expression of CDK1 mRNA21568272
C022186xanthatinxanthatin results in increased phosphorylation of CDK1 protein29074359
C094299ZD 9331ZD 9331 results in increased expression of CDK1 mRNA15342418
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDK1 mRNA20370541
C000588918ziyuglycoside IIziyuglycoside II results in decreased expression of and results in increased phosphorylation of CDK1 protein24680927
C000588918ziyuglycoside IIziyuglycoside II results in decreased expression of CDK1 protein24680927
C088658zoledronic acidzoledronic acid results in decreased expression of CDK1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0003682chromatin binding-IEA-  
GO:0004672protein kinase activity-IDA22854038  
GO:0004674protein serine/threonine kinase activity-IDA11298763  19879842  21871177  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IDA11069302  18477460  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IMP24746669  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-TAS-  
GO:0005515protein binding-IPI7815540  9001210  9988268  10373560  11069302  11574543  
11687586  12612082  15148369  17283331  17349584  17681274  
18337751  18408765  18477460  19879842  20395957  21041660  
21871177  23602568  23799914  24218572  24358021  25218637  
25416956  25852190  26496610  26808496  
GO:0005524ATP binding-IEA-  
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity-IDA12721286  
GO:0030332cyclin binding-IDA7739547  
GO:0030332cyclin binding-IPI1312467  24746669  
GO:0030544Hsp70 protein binding-IEA-  
GO:0035173histone kinase activity-IDA21871177  
GO:0097472cyclin-dependent protein kinase activity-IDA1312467  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0000187activation of MAPK activity-TAS-  
GO:0000226microtubule cytoskeleton organization-IBA21873635  
GO:0000226microtubule cytoskeleton organization-TAS21655336  
GO:0006260DNA replication-TAS21655336  
GO:0006281DNA repair-TAS21655336  
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IMP24746669  
GO:0006915apoptotic process-IEA-  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0007077mitotic nuclear envelope disassembly-TAS-  
GO:0007095mitotic G2 DNA damage checkpoint-IEA-  
GO:0007098centrosome cycle-TAS19364923  
GO:0007344pronuclear fusion-TAS21535261  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0007569cell aging-IEA-  
GO:0008283cell proliferation-IEA-  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0010468regulation of gene expression-IBA21873635  
GO:0010628positive regulation of gene expression-IEA-  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-IMP24746669  
GO:0014038regulation of Schwann cell differentiation-TAS17200138  
GO:0014070response to organic cyclic compound-IEA-  
GO:0014075response to amine-IEA-  
GO:0014823response to activity-IEA-  
GO:0016477cell migration-TAS17200138  
GO:0016572histone phosphorylation-IEA-  
GO:0016579protein deubiquitination-TAS-  
GO:0018105peptidyl-serine phosphorylation-IDA11298763  19879842  
GO:0018107peptidyl-threonine phosphorylation-IDA11298763  
GO:0030154cell differentiation-IBA21873635  
GO:0030261chromosome condensation-IEA-  
GO:0030855epithelial cell differentiation-IEP21492153  
GO:0031100animal organ regeneration-IEA-  
GO:0031145anaphase-promoting complex-dependent catabolic process-TAS-  
GO:0033160positive regulation of protein import into nucleus, translocation-IEA-  
GO:0034501protein localization to kinetochore-IDA18195732  
GO:0043066negative regulation of apoptotic process-IDA11069302  
GO:0044772mitotic cell cycle phase transition-IBA21873635  
GO:0045471response to ethanol-IEA-  
GO:0045740positive regulation of DNA replication-IEA-  
GO:0045995regulation of embryonic development-TAS21535261  
GO:0046686response to cadmium ion-IEA-  
GO:0046688response to copper ion-IEA-  
GO:0046718viral entry into host cell-IEA-  
GO:0048678response to axon injury-IEA-  
GO:0051301cell division-IEA-  
GO:0055015ventricular cardiac muscle cell development-IEA-  
GO:0060045positive regulation of cardiac muscle cell proliferation-IEA-  
GO:0065003protein-containing complex assembly-IEA-  
GO:0070301cellular response to hydrogen peroxide-IEA-  
GO:0090166Golgi disassembly-ISS-  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO:1900182positive regulation of protein localization to nucleus-IMP21871177  
GO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transport-IMP24746669  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IDA1312467  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16109376  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-TAS19917720  
GO:0005759mitochondrial matrixcolocalizes_withIDA24746669  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005813centrosome-IDA17488717  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005876spindle microtubule-IDA11069302  
GO:0016020membrane-HDA19946888  
GO:0030496midbody-IDA11069302  
GO:0070062extracellular exosome-HDA19056867  
GO:0072686mitotic spindle-IBA21873635  
GO:0072686mitotic spindle-IDA17488717  
GO:0097125cyclin B1-CDK1 complex-IMP24746669  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04115p53 signaling pathway
hsa04540Gap junction
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-110056MAPK3 (ERK1) activationTAS
R-HSA-112409RAF-independent MAPK1/3 activationTAS
R-HSA-113507E2F-enabled inhibition of pre-replication complex formationIEA
R-HSA-113510E2F mediated regulation of DNA replicationIEA
R-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1IEA
R-HSA-1538133G0 and Early G1IEA
R-HSA-162582Signal TransductionTAS
R-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesTAS
R-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BTAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin ATAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176412Phosphorylation of the APC/CTAS
R-HSA-176417Phosphorylation of Emi1TAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2299718Condensation of Prophase ChromosomesTAS
R-HSA-2465910MASTL Facilitates Mitotic ProgressionIEA
R-HSA-2500257Resolution of Sister Chromatid CohesionTAS
R-HSA-2514853Condensation of Prometaphase ChromosomesIEA
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-2980766Nuclear Envelope BreakdownTAS
R-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7TAS
R-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4419969Depolymerisation of the Nuclear LaminaTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453274Mitotic G2-G2/M phasesIEA
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-453279Mitotic G1-G1/S phasesIEA
R-HSA-539107Activation of E2F1 target genes at G1/SIEA
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-5687128MAPK6/MAPK4 signalingTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689896Ovarian tumor domain proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestTAS
R-HSA-6804757Regulation of TP53 DegradationTAS
R-HSA-6806003Regulation of TP53 Expression and DegradationTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68875Mitotic ProphaseIEA
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68877Mitotic PrometaphaseIEA
R-HSA-68886M PhaseTAS
R-HSA-68886M PhaseIEA
R-HSA-69205G1/S-Specific TranscriptionIEA
R-HSA-69206G1/S TransitionIEA
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionIEA
R-HSA-69275G2/M TransitionTAS
R-HSA-69275G2/M TransitionIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69478G2/M DNA replication checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexTAS
R-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointTAS
R-HSA-8854518AURKA Activation by TPX2TAS
R-HSA-8878166Transcriptional regulation by RUNX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26622675Pathogenic mechanisms of lung adenocarcinoma in smokers and non-smokers determined by gene expression interrogation. (2015 Sep)Hu YOncol Lett
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. (2014 Jun)Gelernter JMol Psychiatry
21367897Treatment of a human papillomavirus type 31b-positive cell line with benzo[a]pyrene increases viral titer through activation of the Erk1/2 signaling pathway. (2011 May)Bowser BSJ Virol
25888331A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma. (2015 Mar 27)Kavalieris LBMC Urol
15837074Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway. (2005 Apr)Drukteinis JSPlacenta
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics