Gene: ZNF623

9831
-
zinc finger protein 623
protein-coding
8q24.3
Ensembl:ENSG00000183309 Vega:OTTHUMG00000165186 UniprotKB:O75123
NC_000008.11
SNP Mapped
2   ANCO-SNPs
AD
0   
9.489e-1 (AD)  6.839e-1 (ND)   (Frontal_Cortex)
6.662e-1 (AD)  7.088e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12679735chr8:143651635 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3750204chr8:143650280 (GRCh38.p7)G>A / G>C / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP53BP10.908
TNPO30.901
RNF1110.898
TUBGCP40.885
MYO9A0.885
IPPK0.878
SMCR80.877
SSH10.876
SBNO10.876
PRR14L0.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.413
APOM-0.402
BCL7C-0.394
S100A1-0.389
MYL3-0.38
RBP1-0.379
OR4F5-0.374
HES1-0.373
C19orf18-0.366
HEY2-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ZNF623 gene27153756
D019327Copper SulfateCopper Sulfate results in decreased expression of ZNF623 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of ZNF623 mRNA19167446
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZNF623 mRNA22079256
D005557FormaldehydeFormaldehyde results in decreased expression of ZNF623 mRNA20655997
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZNF623 mRNA28001369
D010936Plant ExtractsPlant Extracts results in increased expression of ZNF623 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZNF623 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ZNF623 mRNA22079256
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ZNF623 mRNA25351596
C017947sodium arsenitesodium arsenite results in decreased expression of ZNF623 mRNA22714537
D014635Valproic AcidValproic Acid results in decreased expression of ZNF623 mRNA28001369
D014638VanadatesVanadates results in increased expression of ZNF623 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal