Gene: ZEB2

9839
HSPC082|SIP-1|SIP1|SMADIP1|ZFHX1B
zinc finger E-box binding homeobox 2
protein-coding
2q22.3
Ensembl:ENSG00000169554 MIM:605802 Vega:OTTHUMG00000187624 UniprotKB:O60315
NG_016431.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.260e-2 (AD)  4.909e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12336777chr2:145210222ZEB28.800e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNK10.936
PTP4A20.931
ANKRD400.926
GAB20.921
MAP4K40.915
DYNC1LI20.913
RASSF20.91
CDK190.905
AIF1L0.902
PLA2G160.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.433
OR4F5-0.354
PCDH8-0.351
CUX2-0.351
CHRNA2-0.349
PRTN3-0.347
POU3F1-0.343
SCRT2-0.337
SHISA8-0.335
CCNO-0.335

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of ZEB2 mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ZEB2 mRNA"27291303
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of ZEB2 mRNA"23829299
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of ZEB2 protein26194647
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ZEB2 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ZEB2 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB2 mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of ZEB2 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ZEB2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ZEB2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ZEB2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ZEB2 mRNA24449571
D001151ArsenicArsenic affects the expression of ZEB2 mRNA18414638
D001151ArsenicArsenic results in decreased expression of ZEB2 mRNA19654921
D004958EstradiolEstradiol results in decreased expression of ZEB2 mRNA20068009
C006780bisphenol Abisphenol A affects the methylation of ZEB2 promoter27334623
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZEB2 mRNA28628672
D002220CarbamazepineCarbamazepine affects the expression of ZEB2 mRNA22634333
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ZEB2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ZEB2 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ZEB2 mRNA16934159
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ZEB2 mRNA26272509
D002737ChloropreneChloroprene results in decreased expression of ZEB2 mRNA23125180
D002737ChloropreneChloroprene results in increased expression of ZEB2 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ZEB2 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of ZEB2 mRNA18353800
D003471CuprizoneCuprizone results in decreased expression of ZEB2 mRNA26577399
D003703DemecolcineDemecolcine results in increased expression of ZEB2 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in increased expression of ZEB2 mRNA26763390
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZEB2 mRNA28628672
D003976DiazinonDiazinon results in increased expression of ZEB2 mRNA29108742
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ZEB2 mRNA21266533
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of ZEB2 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of ZEB2 mRNA27392435|2759478
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of ZEB2 mRNA]27392435
D004041Dietary FatsDietary Fats results in increased expression of ZEB2 mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ZEB2 mRNA25242112
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ZEB2 mRNA25380136
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of ZEB2 protein19167416
C061365flusilazoleflusilazole affects the expression of ZEB2 mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ZEB2 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of ZEB2 mRNA23649840
D017313FenretinideFenretinide results in decreased expression of ZEB2 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of ZEB2 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZEB2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ZEB2 mRNA28628672
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of ZEB2 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of ZEB2 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of ZEB2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZEB2 mRNA26254443
D008095Lithocholic AcidLithocholic Acid results in increased expression of ZEB2 mRNA19000923
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ZEB2 mRNA26378955
D015122MercaptopurineMercaptopurine results in increased expression of ZEB2 mRNA23358152
C042720mercuric bromidemercuric bromide results in decreased expression of ZEB2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ZEB2 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ZEB2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ZEB2 mRNA"26251327
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ZEB2 mRNA"29244179
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ZEB2 mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of ZEB2 mRNA19812364
C017557nickel subsulfidenickel subsulfide results in increased expression of ZEB2 mRNA21086188
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ZEB2 mRNA19074003
D019319Okadaic AcidOkadaic Acid results in increased expression of ZEB2 mRNA19000923
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of ZEB2 mRNA24888373
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ZEB2 mRNA25729387
D052638Particulate MatterParticulate Matter results in increased expression of ZEB2 mRNA28846189
D052638Particulate MatterParticulate Matter results in increased expression of ZEB2 protein28846189
C410127PCB 180PCB 180 results in decreased expression of ZEB2 mRNA23829299
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ZEB2 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ZEB2 mRNA19429403
D010634PhenobarbitalPhenobarbital results in decreased expression of ZEB2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ZEB2 mRNA19000923
D010634PhenobarbitalPhenobarbital results in decreased expression of ZEB2 protein24157574
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZEB2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ZEB2 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of ZEB2 mRNA23557933
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of ZEB2 mRNA24888373
D011192Potassium DichromatePotassium Dichromate results in increased expression of ZEB2 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of ZEB2 mRNA19000923
D011441PropylthiouracilPropylthiouracil results in decreased expression of ZEB2 mRNA22504374
C059514resveratrolresveratrol affects the expression of ZEB2 mRNA26934322
C059514resveratrolresveratrol inhibits the reaction [EGF protein results in increased expression of ZEB2 mRNA]21794976
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ZEB2 mRNA25895662
D012834SilverSilver results in decreased expression of ZEB2 mRNA26551752
D012834SilverSilver results in decreased expression of ZEB2 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of ZEB2 mRNA21292642
D018038Sodium SeleniteSodium Selenite results in decreased expression of ZEB2 mRNA23274088
C471405sorafenibsorafenib results in decreased expression of ZEB2 mRNA21360571
D013311StreptozocinSOD1 protein inhibits the reaction [Streptozocin results in decreased expression of ZEB2 mRNA]27629361
D013311StreptozocinStreptozocin results in decreased expression of ZEB2 mRNA27629361
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ZEB2 mRNA26378955
C016766sulforafansulforafan results in decreased expression of ZEB2 mRNA26833863
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ZEB2 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZEB2 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZEB2 mRNA24154488|2756255
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB2 mRNA16979875
C009495titanium dioxidetitanium dioxide results in increased expression of ZEB2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ZEB2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ZEB2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ZEB2 mRNA21934132
C011559tributyltintributyltin results in increased expression of ZEB2 mRNA27614199
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZEB2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of ZEB2 mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of ZEB2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of ZEB2 mRNA28001369
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ZEB2 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA20516212  
GO:0005515protein binding-IPI26028330  
GO:0019208phosphatase regulator activity-NAS11477103  
GO:0043565sequence-specific DNA binding-IDA20516212  
GO:0046872metal ion binding-IEA-  
GO:0070412R-SMAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12837246  20516212  
GO:0000122negative regulation of transcription by RNA polymerase II-IMP24769727  
GO:0001755neural crest cell migration-IEA-  
GO:0001756somitogenesis-IEA-  
GO:0001843neural tube closure-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007399nervous system development-NAS11279515  
GO:0021540corpus callosum morphogenesis-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0021846cell proliferation in forebrain-IEA-  
GO:0021957corticospinal tract morphogenesis-IEA-  
GO:0030177positive regulation of Wnt signaling pathway-IEA-  
GO:0043507positive regulation of JUN kinase activity-IEA-  
GO:0045636positive regulation of melanocyte differentiation-ISS24769727  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP24769727  
GO:0048023positive regulation of melanin biosynthetic process-IC24769727  
GO:0048066developmental pigmentation-ISS24769727  
GO:0048668collateral sprouting-IEA-  
GO:0050772positive regulation of axonogenesis-IEA-  
GO:0061373mammillary axonal complex development-IEA-  
GO:0097324melanocyte migration-ISS24769727  
GO:1902748positive regulation of lens fiber cell differentiation-IEA-  
GO:1903056regulation of melanosome organization-ISS24769727  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA20516212  
GO:0005634nucleus-IDA24769727  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25600647beta-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition. (2015 Mar 15)Pillai SCancer Res
29375721Dysregulation of miR-200 family microRNAs and epithelial-mesenchymal transition markers in oral squamous cell carcinoma. (2018 Jan)Arunkumar GOncol Lett
24354880Effects of a functional variant c.353T>C in snai1 on risk of two contextual diseases. Chronic obstructive pulmonary disease and lung cancer. (2014 Jan 15)Yang LAm J Respir Crit Care Med