Gene: TESPA1

9840
HSPC257|KIAA0748
thymocyte expressed, positive selection associated 1
protein-coding
12q13.2
Ensembl:ENSG00000135426 MIM:615664 Vega:OTTHUMG00000165407 UniprotKB:A2RU30
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.258e-2 (AD)  5.366e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2252795chr12:54949844 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CBLN20.965
KCNS10.948
ENC10.942
GABBR20.936
MEF2C0.936
MPPED10.933
RGS40.929
HAPLN40.924
SRRM40.922
SATB20.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAP1-0.623
LRAT-0.555
ARHGEF5-0.553
EVA1A-0.549
WWTR1-0.546
TFPI2-0.546
C1orf87-0.546
C9orf135-0.542
HEY2-0.53
SLC51B-0.527

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TESPA1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TESPA1 mRNA24449571
D001151ArsenicArsenic results in increased methylation of TESPA1 gene24525453
C008261lead acetatelead acetate results in increased expression of TESPA1 mRNA21829687
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TESPA1 mRNA"25554681
D009532NickelNickel results in increased expression of TESPA1 mRNA24768652|2558310
C005556propionaldehydepropionaldehyde results in decreased expression of TESPA1 mRNA26079696
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TESPA1 gene25560391
C088658zoledronic acidzoledronic acid results in decreased expression of TESPA1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010387COP9 signalosome assembly-ISS-  
GO:0033089positive regulation of T cell differentiation in thymus-ISS-  
GO:0050862positive regulation of T cell receptor signaling pathway-IBA21873635  
GO:0050862positive regulation of T cell receptor signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0008180COP9 signalosome-IDA22561606  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal