Gene: GAB2

9846
-
GRB2 associated binding protein 2
protein-coding
11q14.1
Ensembl:ENSG00000033327 MIM:606203 Vega:OTTHUMG00000166673 UniprotKB:Q9UQC2
NG_016171.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.283e-1 (AD)  8.191e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNK10.932
MAP4K40.93
PTP4A20.923
ZEB20.921
ANKRD400.912
DYNC1LI20.903
LPAR10.902
TP53INP20.898
MAP40.894
PKP40.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.431
OR4F29-0.407
LTK-0.395
PCDH8-0.388
POU3F1-0.388
CHRNA2-0.379
GRB14-0.373
CALB2-0.359
PRTN3-0.357
ASB2-0.353

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GAB2 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GAB2 mRNA19933214
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GAB2 mRNA"21346803
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GAB2 mRNA]18700144
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of GAB2 mRNA]21233418
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GAB2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GAB2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GAB2 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GAB2 mRNA"26238291
C044887beta-methylcholinebeta-methylcholine affects the expression of GAB2 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of GAB2 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of GAB2 gene22576693
C006780bisphenol Abisphenol A results in decreased methylation of GAB2 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of GAB2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GAB2 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of GAB2 mRNA24752500
D019327Copper SulfateCopper Sulfate results in increased expression of GAB2 mRNA21595052
D019327Copper SulfateCopper Sulfate results in increased expression of GAB2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of GAB2 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of GAB2 mRNA19770486
D002945CisplatinCisplatin results in increased expression of GAB2 mRNA27594783
D004008DiclofenacDiclofenac affects the expression of GAB2 mRNA24752500
C000944dicrotophosdicrotophos results in increased expression of GAB2 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GAB2 mRNA22079256
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of GAB2 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of GAB2 mRNA21233418
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GAB2 mRNA28329830
D005485FlutamideFlutamide results in increased expression of GAB2 mRNA24793618
C069837fullerene C60fullerene C60 results in decreased expression of GAB2 mRNA19167457
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GAB2 mRNA20044591
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GAB2 mRNA23086925
C008261lead acetatelead acetate results in increased expression of GAB2 mRNA20542052
C045463leflunomideleflunomide results in increased expression of GAB2 mRNA28988120
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of GAB2 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GAB2 mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GAB2 mRNA"26251327
C028007nickel monoxidenickel monoxide results in decreased expression of GAB2 mRNA19167457
D010634PhenobarbitalPhenobarbital affects the expression of GAB2 mRNA19159669
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GAB2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GAB2 mRNA22079256
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of GAB2 mRNA"21148743
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GAB2 mRNA19933214
D014212TretinoinFGF2 protein promotes the reaction [Tretinoin results in increased expression of GAB2 protein]16009726
D014212TretinoinGAB2 protein promotes the reaction [FGF2 protein results in decreased susceptibility to Tretinoin]16009726
D014212TretinoinGAB2 protein results in decreased susceptibility to Tretinoin16009726
D014212TretinoinTretinoin results in increased expression of GAB2 protein16009726
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GAB2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of GAB2 mRNA29024780
D014520UrethaneUrethane results in increased expression of GAB2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of GAB2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GAB2 mRNA19101580
D014810Vitamin EVitamin E results in increased expression of GAB2 mRNA19244175
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]23994090

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005068transmembrane receptor protein tyrosine kinase adaptor activity-IDA19172738  
GO:0005515protein binding-IPI10704825  10913131  15170389  15750601  16219545  16253990  
19172738  19380743  20936779  21706016  25416956  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-ISS-  
GO:0043325phosphatidylinositol-3,4-bisphosphate binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IEA-  
GO:0007411axon guidance-TAS-  
GO:0008284positive regulation of cell proliferation-IDA19172738  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030316osteoclast differentiation-IMP15750601  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0043306positive regulation of mast cell degranulation-ISS-  
GO:0048015phosphatidylinositol-mediated signaling-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA19172738  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA19172738  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa05220Chronic myeloid leukemia
Reactome ID Reactome Term Evidence
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-1839117Signaling by cytosolic FGFR1 fusion mutantsTAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingIEA
R-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilizationTAS
R-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilizationIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-422475Axon guidanceTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-451927Interleukin-2 family signalingIEA
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-8853659RET signalingTAS
R-HSA-8983432Interleukin-15 signalingIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-912526Interleukin receptor SHC signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28960030GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers. (2017 Nov)Park YRJ Korean Med Sci
20675872[Risk factors for Alzheimer's disease]. (2010 Jul)Ikeda TBrain Nerve
29207374Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936. (2017 Dec 1)Harris SEAging (Albany NY)