Gene: LRIG2

9860
LIG-2|LIG2|UFS2
leucine rich repeats and immunoglobulin like domains 2
protein-coding
1p13.2
Ensembl:ENSG00000198799 MIM:608869 Vega:OTTHUMG00000012133 UniprotKB:O94898
NG_042819.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.755e-1 (AD)  2.974e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRCH30.892
UBN20.885
TTC170.882
INO80D0.877
PAN30.875
AGO30.87
ATP6V0A20.869
RC3H10.865
ZSCAN300.864
ZNF8410.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.476
OR4F29-0.429
KLRC2-0.261
OR4F16-0.229
NANOGNB-0.214
HMHB1-0.198
KRT78-0.193
PAGE4-0.19
PLA2G5-0.185
CNBD2-0.176

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of LRIG2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRIG2 mRNA22300585
C006780bisphenol Abisphenol A affects the expression of LRIG2 mRNA25181051
D016572CyclosporineCyclosporine results in increased expression of LRIG2 mRNA20106945
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LRIG2 mRNA29097150
D005557FormaldehydeFormaldehyde results in decreased expression of LRIG2 mRNA20655997
D017313FenretinideFenretinide results in increased expression of LRIG2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRIG2 mRNA25613284
C045463leflunomideleflunomide results in increased expression of LRIG2 mRNA28988120
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of LRIG2 mRNA19074003
D011192Potassium DichromatePotassium Dichromate results in decreased expression of LRIG2 mRNA23608068
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of LRIG2 mRNA19074003
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LRIG2 mRNA25613284
D014635Valproic AcidValproic Acid affects the expression of LRIG2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LRIG2 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LRIG2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007605sensory perception of sound-IEA-  
GO:0010640regulation of platelet-derived growth factor receptor signaling pathway-IEA-  
GO:0048681negative regulation of axon regeneration-IEA-  
GO:0051045negative regulation of membrane protein ectodomain proteolysis-IEA-  
GO:0060384innervation-IEA-  
GO:2000010positive regulation of protein localization to cell surface-IEA-  
GO:2001222regulation of neuron migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030426growth cone-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0097708intracellular vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24998916Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome. (2014 Apr 15)Lindstrom AKEur J Histochem
25813475LRIG1 is a prognostic biomarker in non-small cell lung cancer. (2015)Kvarnbrink SActa Oncol