Gene: TRIM66

9866
C11orf29|TIF1D|TIF1DELTA
tripartite motif containing 66
protein-coding
11p15.4
Ensembl:ENSG00000166436 MIM:612000 Vega:OTTHUMG00000150481 UniprotKB:O15016
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.283e-1 (AD)  7.804e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10840110chr11:8682544 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LMLN0.898
TRANK10.887
L3MBTL10.871
ARMC20.869
CAPRIN20.865
RIC30.861
PHC10.858
MAP3K120.857
DOPEY10.854
ZMYM30.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.505
EIF4EBP1-0.454
ROM1-0.446
ZNF114-0.429
VAX2-0.421
MYL3-0.42
TMEM102-0.418
HEBP2-0.418
FAM89A-0.417
COPZ2-0.416

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in decreased expression of TRIM66 mRNA25929836
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRIM66 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TRIM66 mRNA24901218
C006780bisphenol Abisphenol A results in decreased expression of TRIM66 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRIM66 mRNA28628672
D003471CuprizoneCuprizone results in increased expression of TRIM66 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of TRIM66 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRIM66 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRIM66 mRNA28628672
C016366dibenzothiophenedibenzothiophene results in decreased expression of TRIM66 mRNA23656968
D002945CisplatinCisplatin results in increased expression of TRIM66 mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of TRIM66 mRNA26033743
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRIM66 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRIM66 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRIM66 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRIM66 mRNA28628672
C544151jinfukangjinfukang results in increased expression of TRIM66 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TRIM66 mRNA24796395
C045463leflunomideleflunomide results in decreased expression of TRIM66 mRNA28988120
C045463leflunomideleflunomide results in increased expression of TRIM66 mRNA19751817
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TRIM66 mRNA24810058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRIM66 mRNA26377647
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TRIM66 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TRIM66 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of TRIM66 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of TRIM66 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IBA21873635  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0016235aggresome-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal