Gene: SETDB1

9869
ESET|H3-K9-HMTase4|KG1T|KMT1E|TDRD21
SET domain bifurcated 1
protein-coding
1q21.3
Ensembl:ENSG00000143379 MIM:604396 Vega:OTTHUMG00000035003 UniprotKB:Q15047
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.087e-1 (AD)  1.657e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUP2140.924
ASXL10.92
TTC170.92
MDC10.916
FKBP150.912
PIGG0.911
METTL30.908
CHD80.9
TNRC6A0.9
CLK20.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.553
OR4F29-0.53
KLRC2-0.282
MTRNR2L6-0.236
MTRNR2L9-0.228
OR4F16-0.222
MTRNR2L10-0.195
TRDN-0.183
PAGE4-0.183
PTH-0.177

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SETDB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SETDB1 mRNA"27188386
C006632arsenic trioxidearsenic trioxide affects the methylation of SETDB1 promoter26046465
C006632arsenic trioxidearsenic trioxide affects the localization of SETDB1 protein21921037
C006632arsenic trioxidearsenic trioxide results in increased expression of SETDB1 mRNA21921037
D001280AtrazineAtrazine results in increased expression of SETDB1 mRNA25929836
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SETDB1 mRNA"19150397
D001599BerberineBerberine results in increased expression of SETDB1 mRNA27311644
C006780bisphenol Abisphenol A affects the expression of SETDB1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SETDB1 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SETDB1 mRNA18804290
C007262deoxynivalenoldeoxynivalenol results in increased expression of SETDB1 mRNA26988607
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SETDB1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SETDB1 mRNA17942748
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of SETDB1 mRNA22634610
C010974glyphosateglyphosate results in increased expression of SETDB1 mRNA26302742
D006418HemeHeme metabolite results in decreased expression of SETDB1 mRNA19191707
D001556LindaneLindane results in increased expression of SETDB1 mRNA18804290
D008748MethylcholanthreneMethylcholanthrene results in increased expression of SETDB1 mRNA18804290
D010416PentachlorophenolPentachlorophenol results in increased expression of SETDB1 mRNA23892564
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SETDB1 mRNA19073995
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of SETDB1 mRNA"26680231
D013605T-2 ToxinT-2 Toxin results in increased expression of SETDB1 mRNA26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SETDB1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SETDB1 mRNA17942748
D019284ThapsigarginThapsigargin results in increased expression of SETDB1 protein24648495
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SETDB1 mRNA28065790
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SETDB1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SETDB1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SETDB1 mRNA23179753|2438349
C025643vinclozolinvinclozolin results in increased expression of SETDB1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003682chromatin binding-IDA27029610  
GO:0005515protein binding-IPI16682412  17066076  17577629  20871592  21170338  26022416  
27029610  
GO:0008270zinc ion binding-IEA-  
GO:0018024histone-lysine N-methyltransferase activity-IEA-  
GO:1990841promoter-specific chromatin binding-IDA24623306  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0007265Ras protein signal transduction-IMP24623306  
GO:0033273response to vitamin-IEA-  
GO:0034968histone lysine methylation-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0090309positive regulation of methylation-dependent chromatin silencing-IMP24623306  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IEA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa00310Lysine degradation
Reactome ID Reactome Term Evidence
R-HSA-3214841PKMTs methylate histone lysinesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26542178Prognostic value of ERCC1, RRM1, BRCA1 and SETDB1 in early stage of non-small cell lung cancer. (2016 Aug)Lafuente-Sanchis AClin Transl Oncol