Gene: LRBA

987
BGL|CDC4L|CVID8|LAB300|LBA
LPS responsive beige-like anchor protein
protein-coding
4q31.3
Ensembl:ENSG00000198589 MIM:606453 Vega:OTTHUMG00000161443 UniprotKB:P50851
NG_032855.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.701e-1 (AD)  5.769e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11099777chr4:150854107 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS13B0.899
AKAP90.866
KIAA11090.865
SYNRG0.858
PCMTD10.854
RSF10.85
VWA80.846
DNAJC130.846
DYNC2H10.844
PIKFYVE0.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.483
OR4F29-0.454
HMX1-0.322
NANOGNB-0.271
GNG8-0.26
RRAD-0.254
S100A14-0.253
S100A1-0.251
NANOS2-0.247
C17orf64-0.238

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of LRBA mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of LRBA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of LRBA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of LRBA mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of LRBA mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of LRBA mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of LRBA mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of LRBA mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of LRBA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LRBA protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LRBA mRNA21641981|2210060
D000393Air PollutantsAir Pollutants analog results in decreased expression of LRBA mRNA21757418
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRBA mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LRBA mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LRBA mRNA"26238291
C053541bicalutamidebicalutamide results in increased expression of LRBA mRNA15790403
C006780bisphenol Abisphenol A results in decreased expression of LRBA mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LRBA gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of LRBA mRNA14729362
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LRBA gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of LRBA mRNA19320972
D016572CyclosporineCyclosporine results in decreased expression of LRBA mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of LRBA mRNA21198554
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of LRBA mRNA27392435
D002945CisplatinCisplatin results in decreased expression of LRBA mRNA27392435|2759478
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in increased expression of LRBA mRNA21858171
D004026DieldrinDieldrin results in increased expression of LRBA mRNA23041725
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LRBA mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LRBA mRNA23649840
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of LRBA mRNA]15016801
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LRBA gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of LRBA mRNA23649840
D017313FenretinideFenretinide results in increased expression of LRBA mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of LRBA mRNA14729362
C492448ICG 001ICG 001 results in decreased expression of LRBA mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of LRBA mRNA27392435
C544151jinfukangjinfukang results in decreased expression of LRBA mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of LRBA mRNA24796395
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LRBA gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LRBA mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LRBA mRNA23649840
D009151Mustard GasMustard Gas results in decreased expression of LRBA mRNA25102026
D009151Mustard GasMustard Gas affects the expression of LRBA mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LRBA mRNA"25554681
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] affects the expression of LRBA mRNA"25510870
D010672PhenytoinPhenytoin results in increased expression of LRBA mRNA20345932
C006253pirinixic acidpirinixic acid results in increased expression of LRBA mRNA23811191
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in increased expression of LRBA mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LRBA mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LRBA mRNA22079256
C016104sodium bichromatesodium bichromate affects the expression of LRBA mRNA22110744
D012999SomanSoman results in decreased expression of LRBA mRNA19281266
C061133tamibarotenetamibarotene affects the expression of LRBA mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LRBA mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LRBA mRNA28065790
D014212TretinoinTretinoin results in decreased expression of LRBA mRNA15498508
D014635Valproic AcidValproic Acid affects the expression of LRBA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of LRBA gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LRBA mRNA23179753
C025643vinclozolinvinclozolin results in increased expression of LRBA mRNA23034163
D014750VincristineVincristine results in decreased expression of LRBA mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal