Gene: SEC24D

9871
CLCRP2
SEC24 homolog D, COPII coat complex component
protein-coding
4q26
Ensembl:ENSG00000150961 MIM:607186 Vega:OTTHUMG00000132957 UniprotKB:O94855
NG_042032.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.972e-1 (AD)  5.869e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC24A0.826
ELL20.815
OGFOD10.81
EIF2AK30.797
SCYL20.796
DCP1A0.796
NUP980.793
SPTY2D10.784
RIOK30.783
GBE10.782

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.412
DIAPH3-0.395
C16orf74-0.368
BTBD17-0.356
NXNL1-0.353
ARSF-0.338
KCNJ16-0.337
ALDH1L1-AS2-0.332
ARSE-0.33
GPR17-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SEC24D mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of SEC24D mRNA"19095052
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SEC24D mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of SEC24D mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of SEC24D mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SEC24D mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SEC24D mRNA22100608
C547126AZM551248AZM551248 results in increased expression of SEC24D mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SEC24D mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SEC24D mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SEC24D mRNA22228805
C006780bisphenol Abisphenol A affects the expression of SEC24D mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SEC24D mRNA25181051
D016642BupropionSEC24D protein results in increased susceptibility to Bupropion27555326
C018021cobaltous chloridecobaltous chloride results in increased expression of SEC24D mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SEC24D mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SEC24D mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of SEC24D mRNA19167446
D003471CuprizoneCuprizone results in increased expression of SEC24D mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of SEC24D mRNA20106945|2163298
C089595cylindrospermopsincylindrospermopsin results in decreased expression of SEC24D mRNA24921660
C093628cyproconazolecyproconazole results in increased expression of SEC24D mRNA22334560
D002945CisplatinCisplatin results in decreased expression of SEC24D mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of SEC24D mRNA18042831
D004237DiuronDiuron results in increased expression of SEC24D mRNA21551480
C118739entinostatentinostat results in increased expression of SEC24D mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SEC24D protein23301498
C109476epoxiconazoleepoxiconazole results in increased expression of SEC24D mRNA22334560
D005485FlutamideFlutamide results in increased expression of SEC24D mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of SEC24D mRNA23649840
D019833GenisteinGenistein results in increased expression of SEC24D mRNA15378649
C010974glyphosateglyphosate results in increased expression of SEC24D mRNA25636363
C492448ICG 001ICG 001 results in decreased expression of SEC24D mRNA26191083
C410337K 7174K 7174 results in increased expression of SEC24D mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SEC24D mRNA"24972896
D008627Mercuric ChlorideMercuric Chloride affects the expression of SEC24D mRNA20353558
D008727MethotrexateMethotrexate affects the expression of SEC24D mRNA18502557
D007050IbogaineSEC24D protein results in increased susceptibility to Ibogaine27555326
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SEC24D mRNA23179753|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SEC24D mRNA23649840
C008493methylselenic acidmethylselenic acid affects the expression of SEC24D mRNA14617803
C523184mocetinostatmocetinostat results in increased expression of SEC24D mRNA27255383
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SEC24D mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SEC24D mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of SEC24D mRNA24136188
D009532NickelNickel results in increased expression of SEC24D mRNA24768652|2558310
C017557nickel subsulfidenickel subsulfide results in increased expression of SEC24D mRNA21086188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SEC24D mRNA20971185
C055122orlistatorlistat results in increased expression of SEC24D mRNA18796435
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SEC24D mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of SEC24D mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SEC24D mRNA26272509
D010261ParaoxonParaoxon results in increased expression of SEC24D mRNA17223147
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SEC24D mRNA26272509
C014153pirimiphos methylpirimiphos methyl results in decreased expression of SEC24D mRNA27845199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SEC24D mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of SEC24D mRNA23811191
C045950propiconazolepropiconazole results in increased expression of SEC24D mRNA21278054|2233456
D011794QuercetinQuercetin results in decreased expression of SEC24D mRNA21632981
C017947sodium arsenitesodium arsenite results in increased stability of SEC24D mRNA25493608
C017947sodium arsenitesodium arsenite results in increased expression of SEC24D mRNA25270620
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SEC24D mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SEC24D mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SEC24D mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SEC24D mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SEC24D mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SEC24D mRNA"24407104
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SEC24D mRNA"26179874
C080163trovafloxacintrovafloxacin results in decreased expression of SEC24D mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SEC24D mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SEC24D mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SEC24D mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of SEC24D mRNA19136453|2489608
D019287Zinc SulfateZinc Sulfate results in increased expression of SEC24D mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IPI18843296  
GO:0005515protein binding-IPI16189514  21516116  24405750  25416956  
GO:0008270zinc ion binding-IDA18843296  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-IEA-  
GO:0002474antigen processing and presentation of peptide antigen via MHC class I-TAS-  
GO:0006886intracellular protein transport-IEA-  
GO:0006888ER to Golgi vesicle-mediated transport-IMP20427317  
GO:0006888ER to Golgi vesicle-mediated transport-NAS10329445  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0048208COPII vesicle coating-TAS-  
GO:0090110cargo loading into COPII-coated vesicle-IDA17499046  18843296  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005829cytosol-TAS-  
GO:0012507ER to Golgi transport vesicle membrane-TAS-  
GO:0030127COPII vesicle coat-IDA17499046  
GO:0030127COPII vesicle coat-NAS10329445  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1430728MetabolismIEA
R-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)IEA
R-HSA-168256Immune SystemTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-556833Metabolism of lipidsIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5694530Cargo concentration in the ERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957322Metabolism of steroidsIEA
R-HSA-948021Transport to the Golgi and subsequent modificationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHCTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21187334Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. (2011 Jan)Srinivasan RJ Gen Physiol