Gene info: ID 9874

Gene: TLK1

GENE ID: 9874

Synonyms: PKU-beta

Description: tousled like kinase 1

Gene type: protein-coding

Location: 2q31.1

dbXrefs: Ensembl:ENSG00000198586 MIM:608438 Vega:OTTHUMG00000132243 UniprotKB:Q9UKI8

RefSeq: NC_000002.12

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.610e-1 (AD) 9.798e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs16859177	chr2:171150066 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg24527751	chr2:171877888	TLK1		1.580e-9	Alcohol consumption per day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PJA2	0.96
OPA1	0.95
TOMM20	0.949
USP33	0.948
PSIP1	0.946
GDAP1	0.946
ATAD1	0.946
RAB6A	0.946
BCAP29	0.945
CDC42SE2	0.945

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.627
OR4F29	-0.612
CSAG1	-0.388
MTRNR2L10	-0.346
MTRNR2L6	-0.342
WDR38	-0.334
EVC2	-0.334
MTRNR2L9	-0.327
NKX6-1	-0.317
CNN2	-0.315

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C066841	2,3,7,8-tetrabromodibenzo-4-dioxin	"2,3,7,8-tetrabromodibenzo-4-dioxin results in decreased expression of TLK1 protein"	27604104
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of TLK1 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLK1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLK1 mRNA"	27188386
C015060	4-chloro-1,2-diaminobenzene	"TLK1 gene SNP affects the susceptibility to 4-chloro-1,2-diaminobenzene"	25622337
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLK1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLK1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of TLK1 mRNA	21420995\|2223033
D000082	Acetaminophen	Acetaminophen affects the expression of TLK1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of TLK1 gene	27153756
D001280	Atrazine	Atrazine results in increased expression of TLK1 mRNA	25929836
C547126	AZM551248	AZM551248 results in increased expression of TLK1 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of TLK1 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TLK1 mRNA"	19150397
C006780	bisphenol A	bisphenol A results in increased expression of TLK1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of TLK1 mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of TLK1 mRNA	26079696
D002737	Chloroprene	Chloroprene results in increased expression of TLK1 mRNA	23125180
D003471	Cuprizone	Cuprizone results in decreased expression of TLK1 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of TLK1 mRNA	20106945\|2798913
D013759	Dronabinol	Dronabinol results in increased expression of TLK1 mRNA	11015613
D004008	Diclofenac	Diclofenac results in decreased expression of TLK1 mRNA	26934552
D004041	Dietary Fats	Dietary Fats results in increased expression of TLK1 mRNA	25016146
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of TLK1 mRNA	26924002
D005557	Formaldehyde	Formaldehyde results in decreased expression of TLK1 mRNA	23649840
C001277	geldanamycin	geldanamycin results in increased expression of TLK1 mRNA	26705709
D005839	Gentamicins	Gentamicins results in increased expression of TLK1 mRNA	22061828
D005947	Glucose	Glucose results in decreased expression of TLK1 mRNA	17178593
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLK1 mRNA	25613284
C544151	jinfukang	jinfukang results in decreased expression of TLK1 mRNA	27392435
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of TLK1 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of TLK1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of TLK1 mRNA"	25554681
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of TLK1 mRNA	25729387
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in increased expression of TLK1 mRNA	28973697
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of TLK1 mRNA	27153767
D011794	Quercetin	Quercetin results in decreased expression of TLK1 mRNA	21632981
C059514	resveratrol	resveratrol results in decreased expression of TLK1 mRNA	25905778
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of TLK1 mRNA	27862939
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TLK1 mRNA	21570461\|2637764
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLK1 mRNA	25613284
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of TLK1 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of TLK1 mRNA	25729387
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLK1 mRNA"	27188386
C012589	trichostatin A	trichostatin A affects the expression of TLK1 mRNA	28542535
C012589	trichostatin A	trichostatin A results in decreased expression of TLK1 mRNA	24935251\|2627250
D014501	Uranium	Uranium affects the expression of TLK1 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of TLK1 mRNA	15672453
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLK1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of TLK1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of TLK1 mRNA	22083351\|2317975
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TLK1 gene	25560391
D024483	Vitamin K 3	Vitamin K 3 affects the expression of TLK1 mRNA	20829426
C111237	vorinostat	vorinostat results in decreased expression of TLK1 mRNA	22083351

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004674	protein serine/threonine kinase activity	-	IDA	12660173
GO:0004674	protein serine/threonine kinase activity	-	TAS	9427565
GO:0005515	protein binding	-	IPI	25416956
GO:0005524	ATP binding	-	IDA	12660173

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001672	regulation of chromatin assembly or disassembly	-	IDA	12660173
GO:0006325	chromatin organization	-	IEA	-
GO:0006468	protein phosphorylation	-	IDA	12660173
GO:0006886	intracellular protein transport	-	IDA	10588641
GO:0006974	cellular response to DNA damage stimulus	-	IEA	-
GO:0007049	cell cycle	-	IEA	-
GO:0035556	intracellular signal transduction	-	IDA	12660173

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	10523312
GO:0005634	nucleus	-	TAS	9427565

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal