Gene: TOX4

9878
C14orf92|KIAA0737|LCP1|MIG7
TOX high mobility group box family member 4
protein-coding
14q11.2
Ensembl:ENSG00000092203 MIM:614032 Vega:OTTHUMG00000150278 UniprotKB:O94842
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
1.678e-1 (AD)  6.763e-2 (ND)   (Frontal_Cortex)
1.668e-2 (AD)  1.599e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSNK2A10.97
UBQLN10.964
WDR820.958
NOLC10.958
VCP0.958
UBE2Z0.957
ARCN10.957
ARIH10.956
PGK10.956
HNRNPA00.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.689
OR4F29-0.646
MTRNR2L6-0.339
MTRNR2L9-0.32
MTRNR2L10-0.319
KLRB1-0.297
VNN3-0.291
P2RY14-0.283
CTNNA3-0.272
CSAG1-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TOX4 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX4 mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to TOX4 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TOX4 protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX4 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TOX4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TOX4 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TOX4 mRNA16483693
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TOX4 protein]26598702
D001280AtrazineAtrazine results in increased expression of TOX4 mRNA25929836
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TOX4 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TOX4 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TOX4 mRNA27858113
C006780bisphenol Abisphenol A results in decreased expression of TOX4 mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TOX4 mRNA27858113
D002994ClofibrateClofibrate results in increased expression of TOX4 mRNA17585979
D019327Copper SulfateCopper Sulfate results in increased expression of TOX4 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of TOX4 mRNA19770486
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TOX4 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of TOX4 mRNA19467301|2501614
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TOX4 protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TOX4 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TOX4 mRNA20044591
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TOX4 mRNA23649840
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TOX4 mRNA26272509
D012402RotenoneRotenone results in increased expression of TOX4 mRNA19013527
D012643SeleniumSelenium results in increased expression of TOX4 mRNA19244175
C004648testosterone enanthatetestosterone enanthate affects the expression of TOX4 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TOX4 mRNA19465110
C012589trichostatin Atrichostatin A affects the expression of TOX4 mRNA28542535
D014635Valproic AcidValproic Acid results in decreased expression of TOX4 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of TOX4 mRNA22083351
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TOX4 gene25560391
D014810Vitamin EVitamin E results in increased expression of TOX4 mRNA19244175
C088658zoledronic acidzoledronic acid results in increased expression of TOX4 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI20516061  25416956  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000784nuclear chromosome, telomeric regioncolocalizes_withIDA24270157  
GO:0000785chromatin-IDA20516061  
GO:0072357PTW/PP1 phosphatase complex-IDA20516061  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22496870Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers. (2012)Tessema MPLoS One