Gene: TBC1D4

9882
AS160|NIDDM5
TBC1 domain family member 4
protein-coding
13q22.2
Ensembl:ENSG00000136111 MIM:612465 Vega:OTTHUMG00000017088 UniprotKB:O60343
NG_042850.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.055e-1 (AD)  6.518e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ESYT20.848
SLC7A10.805
PCMTD10.799
NAB10.796
NCOA30.792
ANKRD290.78
SOS10.775
SNRK0.774
MEF2A0.767
DNAJC100.765

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.493
OR4F5-0.476
S100A1-0.355
AQP5-0.312
WNT7B-0.303
PLA2G5-0.298
S100A14-0.295
VAX2-0.286
LRAT-0.284
SDS-0.284

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of TBC1D4 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TBC1D4 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TBC1D4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TBC1D4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TBC1D4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TBC1D4 mRNA"25510870
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased phosphorylation of TBC1D4 protein"18063688
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein]]"24343960
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein]24343960|2662746
C103303alitretinoinalitretinoin results in increased phosphorylation of TBC1D4 protein18063688
C103303alitretinoinOligomycins promotes the reaction [alitretinoin results in increased phosphorylation of TBC1D4 protein]18063688
D001205Ascorbic Acid[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TBC1D4 protein]21911000
D001374AzacitidineAzacitidine results in decreased expression of TBC1D4 mRNA19194470
C547126AZM551248AZM551248 results in decreased expression of TBC1D4 mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBC1D4 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of and results in decreased phosphorylation of TBC1D4 protein28739533
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of TBC1D4 mRNA16197558
C039671ciglitazoneciglitazone results in increased phosphorylation of TBC1D4 protein18063688
C018021cobaltous chloridecobaltous chloride results in decreased expression of TBC1D4 mRNA19320972
D003078ColchicineColchicine affects the phosphorylation of TBC1D4 protein18063688
D003078ColchicineColchicine inhibits the reaction [Oligomycins results in increased phosphorylation of TBC1D4 protein]18063688
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TBC1D4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of TBC1D4 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of TBC1D4 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of TBC1D4 mRNA25562108
D003561CytarabineCytarabine results in decreased expression of TBC1D4 mRNA21198554
D003703DemecolcineDemecolcine results in increased expression of TBC1D4 mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TBC1D4 mRNA27392435
D004051Diethylhexyl Phthalate[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TBC1D4 protein]21911000
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein]28526321
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of TBC1D4 protein21911000
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TBC1D4 protein23301498
D005557FormaldehydeFormaldehyde results in increased expression of TBC1D4 mRNA23649840
C049864ginsenoside Reginsenoside Re results in increased phosphorylation of TBC1D4 protein17885204
D005947GlucoseGH1 protein promotes the reaction [Glucose results in increased phosphorylation of TBC1D4 protein]21559284
D005947GlucoseGlucose results in increased phosphorylation of TBC1D4 protein21559284
D017313FenretinideFenretinide results in decreased expression of TBC1D4 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TBC1D4 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D4 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TBC1D4 mRNA27392435
C544151jinfukangjinfukang results in increased expression of TBC1D4 mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TBC1D4 mRNA21641980
D008694MethamphetamineMethamphetamine results in increased expression of TBC1D4 mRNA26307267
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TBC1D4 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TBC1D4 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of TBC1D4 mRNA29191790
C016599mono-(2-ethylhexyl)phthalate[INS1 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of TBC1D4 protein28526321
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein]28526321
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TBC1D4 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TBC1D4 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TBC1D4 mRNA20971185
D009840OligomycinsColchicine inhibits the reaction [Oligomycins results in increased phosphorylation of TBC1D4 protein]18063688
D009840OligomycinsOligomycins promotes the reaction [alitretinoin results in increased phosphorylation of TBC1D4 protein]18063688
D009840OligomycinsOligomycins results in increased phosphorylation of TBC1D4 protein18063688
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TBC1D4 mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of TBC1D4 mRNA18301758
D011441PropylthiouracilPropylthiouracil results in decreased expression of TBC1D4 mRNA24780913
D011794Quercetin"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [Quercetin inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein]]"24343960
D011794QuercetinQuercetin inhibits the reaction [INS1 protein results in increased phosphorylation of TBC1D4 protein]24343960|2662746
D011794QuercetinQuercetin results in increased phosphorylation of TBC1D4 protein24343960|2662746
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TBC1D4 mRNA21641980
D013739TestosteroneTestosterone results in decreased expression of TBC1D4 mRNA20403060
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D4 mRNA25613284
D019772TopotecanTBC1D4 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in decreased expression of TBC1D4 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of TBC1D4 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of TBC1D4 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TBC1D4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TBC1D4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TBC1D4 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TBC1D4 gene25560391
D014747VinblastineTBC1D4 protein affects the susceptibility to Vinblastine16217747
D014750VincristineVincristine results in increased expression of TBC1D4 mRNA23649840
D014810Vitamin E[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TBC1D4 protein]21911000
C088658zoledronic acidzoledronic acid results in decreased expression of TBC1D4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0017137Rab GTPase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0016192vesicle-mediated transport-IMP22908308  
GO:0031339negative regulation of vesicle fusion-IEA-  
GO:0032869cellular response to insulin stimulus-IMP22908308  
GO:0090630activation of GTPase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0031982vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1445148Translocation of GLUT4 to the plasma membraneIEA
R-HSA-199991Membrane TraffickingIEA
R-HSA-5653656Vesicle-mediated transportIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24098343Genome-wide association study of gene by smoking interactions in coronary artery calcification. (2013)Polfus LMPLoS One