Gene: NUAK1

9891
ARK5
NUAK family kinase 1
protein-coding
12q23.3
Ensembl:ENSG00000074590 MIM:608130 Vega:OTTHUMG00000169763 UniprotKB:O60285
NC_000012.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.590e-1 (AD)  9.585e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OPCML0.961
NCALD0.949
RGS40.949
PAK10.948
HECW10.947
MAPK90.947
FAM131B0.946
SATB10.946
PPM1H0.944
CDK140.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.548
HEY2-0.533
RAB13-0.533
CHST14-0.53
STON2-0.524
TMEM176A-0.523
RNF135-0.52
RHOD-0.52
HVCN1-0.52
CYP11A1-0.518

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NUAK1 mRNA"19167446
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NUAK1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NUAK1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of NUAK1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NUAK1 mRNA24449571
D001151ArsenicArsenic affects the methylation of NUAK1 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of NUAK1 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NUAK1 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NUAK1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NUAK1 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of NUAK1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of NUAK1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of NUAK1 mRNA25596134
D002220CarbamazepineCarbamazepine affects the expression of NUAK1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NUAK1 mRNA17484886
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of NUAK1 mRNA25596134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NUAK1 gene20938992
D004002Clodronic AcidClodronic Acid results in decreased expression of NUAK1 mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of NUAK1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of NUAK1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of NUAK1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NUAK1 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of NUAK1 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of NUAK1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of NUAK1 mRNA20106945|2559613
D000069439DasatinibDasatinib results in increased expression of NUAK1 mRNA20579391
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of NUAK1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of NUAK1 mRNA25596134
D019422Dietary SucroseDietary Sucrose results in increased expression of NUAK1 mRNA26033743
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NUAK1 mRNA22079256
D011345FenofibrateFenofibrate results in decreased expression of NUAK1 mRNA25596134
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NUAK1 gene20938992
D017313FenretinideFenretinide results in decreased expression of NUAK1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of NUAK1 mRNA20044591
D007052IbuprofenIbuprofen results in decreased expression of NUAK1 mRNA25596134
D007069IfosfamideIfosfamide results in decreased expression of NUAK1 mRNA25596134
D007213IndomethacinIndomethacin results in increased expression of NUAK1 mRNA16984733
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUAK1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NUAK1 mRNA24796395|2530787
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NUAK1 mRNA25613284
D008558MelphalanMelphalan results in decreased expression of NUAK1 mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of NUAK1 gene20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NUAK1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of NUAK1 mRNA19812364
D009532NickelNickel results in decreased expression of NUAK1 mRNA24768652|2558310
C000594117ON123300ON123300 results in decreased phosphorylation of NUAK1 protein24568969
C000594117ON123300ON123300 results in decreased activity of NUAK1 protein26174628
D010100OxygenOxygen deficiency results in increased expression of NUAK1 mRNA25596134
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NUAK1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NUAK1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NUAK1 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of NUAK1 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of NUAK1 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNA19059307
C089730rosiglitazonerosiglitazone results in decreased expression of NUAK1 mRNA25596134
C547874SAR 020106SAR 020106 results in decreased activity of NUAK1 protein22111927
D012834SilverSilver results in decreased expression of NUAK1 mRNA27131904
D053260SootSoot results in decreased expression of NUAK1 mRNA22461453
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NUAK1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NUAK1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NUAK1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of NUAK1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NUAK1 mRNA28111298
D014212TretinoinTretinoin results in decreased expression of NUAK1 mRNA23724009
C057693troglitazonetroglitazone results in decreased expression of NUAK1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of NUAK1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of NUAK1 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of NUAK1 gene29154799
D014638VanadatesVanadates results in decreased expression of NUAK1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NUAK1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002039p53 binding-IPI21317932  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA19927127  20354225  21317932  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004679AMP-activated protein kinase activity-IBA21873635  
GO:0005515protein binding-IPI19927127  20354225  21317932  25329316  
GO:0005524ATP binding-IEA-  
GO:0035174histone serine kinase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IDA25329316  
GO:0006974cellular response to DNA damage stimulus-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0030155regulation of cell adhesion-IDA20354225  
GO:0035507regulation of myosin-light-chain-phosphatase activity-IDA20354225  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0042127regulation of cell proliferation-TAS21317932  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:2000772regulation of cellular senescence-IDA19927127  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA21317932  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA21317932  
GO:0015630microtubule cytoskeleton-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26174813New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder. (2015 Sep)Alemany SAm J Med Genet B Neuropsychiatr Genet
23459936Exploring the genetic basis of chronic periodontitis: a genome-wide association study. (2013 Jun 1)Divaris KHum Mol Genet