Gene: CDC6

990
CDC18L|HsCDC18|HsCDC6|MGORS5
cell division cycle 6
protein-coding
17q21.2
Ensembl:ENSG00000094804 MIM:602627 Vega:OTTHUMG00000133324 UniprotKB:Q99741
NG_028240.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.492e-1 (AD)  4.088e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT20.816
GRHL10.807
TRERF10.797
ZNF1840.794
MAN1C10.793
STEAP10.793
ITGA90.786
FBXO100.786
RND10.773
SRC0.772

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.494
SLCO1A2-0.465
CTNNA3-0.46
MBNL3-0.451
IL18RAP-0.431
ASB4-0.43
KLRB1-0.429
SH2D1A-0.426
HBA2-0.426
BCAS1-0.426

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CDC6 mRNA"28903501
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of CDC6 mRNA28329830
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of CDC6 mRNA"20453058
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CDC6 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC6 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CDC6 mRNA"23829299
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of CDC6 protein]20862710
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDC6 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC6 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC6 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC6 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of CDC6 mRNA"20713471
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC6 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of CDC6 mRNA"23829299
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of CDC6 mRNA25088246
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of CDC6 mRNA18544908
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CDC6 mRNA"18648102
C4943564-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione results in decreased expression of CDC6 mRNA"17440966
C4943809-methoxy-2-methylellipticinium acetate9-methoxy-2-methylellipticinium acetate inhibits the reaction [arsenic trioxide results in increased expression of CDC6 protein]20862710
D000082AcetaminophenAcetaminophen results in decreased expression of CDC6 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of CDC6 mRNA22230336
D000082AcetaminophenAcetaminophen results in increased expression of CDC6 mRNA18544908
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of CDC6 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CDC6 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CDC6 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDC6 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDC6 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDC6 protein16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CDC6 mRNA"22863853
C006632arsenic trioxide2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of CDC6 protein]20862710
C006632arsenic trioxide9-methoxy-2-methylellipticinium acetate inhibits the reaction [arsenic trioxide results in increased expression of CDC6 protein]20862710
C006632arsenic trioxideAKT1 protein affects the reaction [arsenic trioxide results in increased expression of CDC6 protein]20862710
C006632arsenic trioxidearsenic trioxide results in increased expression of CDC6 mRNA20862710|2325547
C006632arsenic trioxidearsenic trioxide results in increased expression of CDC6 protein20862710|2325547
C006632arsenic trioxideMAPK1 protein affects the reaction [arsenic trioxide results in increased expression of CDC6 protein]20862710
C006632arsenic trioxideMAPK3 protein affects the reaction [arsenic trioxide results in increased expression of CDC6 protein]20862710
C006632arsenic trioxideSB 203580 inhibits the reaction [arsenic trioxide results in increased expression of CDC6 protein]20862710
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of CDC6 mRNA17639512
D001285Atropine[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA17390078
D001379AzathioprineAzathioprine results in decreased expression of CDC6 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDC6 mRNA16120219
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDC6 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC6 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CDC6 mRNA"26238291
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of CDC6 mRNA24758408
D004958EstradiolEstradiol results in increased expression of CDC6 mRNA16474171|1726806
D004958EstradiolTamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CDC6 mRNA]24758408
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of CDC6 mRNA]24758408
D004958EstradiolEstradiol affects the expression of CDC6 mRNA15598610
C053541bicalutamidebicalutamide results in decreased expression of CDC6 mRNA15887248
C053541bicalutamidebicalutamide results in decreased expression of CDC6 protein15887248
C006780bisphenol Abisphenol A results in increased expression of CDC6 mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of CDC6 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of CDC6 mRNA16474171|1726806
C006780bisphenol Abisphenol A results in decreased expression of CDC6 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of CDC6 mRNA25181051
D002185CannabidiolCannabidiol results in decreased expression of CDC6 mRNA21542829
D002220CarbamazepineCarbamazepine affects the expression of CDC6 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CDC6 mRNA17484886|2733941
D002509CephaloridineCephaloridine results in increased expression of CDC6 mRNA18500788
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CDC6 mRNA20350560
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDC6 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDC6 mRNA19376846
D003078ColchicineColchicine results in decreased expression of CDC6 mRNA24211769
D005576ColforsinColforsin results in increased expression of CDC6 mRNA16751804
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDC6 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CDC6 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CDC6 mRNA19167446
C024015cryptolepinecryptolepine results in decreased expression of CDC6 mRNA16120219
D016572CyclosporineCyclosporine results in increased expression of CDC6 mRNA20106945|2556210
D000069439DasatinibDasatinib results in decreased expression of CDC6 mRNA20579391
D003703DemecolcineDemecolcine results in decreased expression of CDC6 mRNA23649840
D003976DiazinonDiazinon affects the expression of CDC6 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDC6 mRNA17361019|2126653
D002945CisplatinCisplatin results in decreased expression of CDC6 mRNA24211769
D002945CisplatinCisplatin results in increased expression of CDC6 mRNA27594783
D002945CisplatinCisplatin results in increased phosphorylation of CDC6 protein22006019
D004008DiclofenacDiclofenac affects the expression of CDC6 mRNA24752500
D004026DieldrinDieldrin affects the expression of CDC6 mRNA22546817
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDC6 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC6 mRNA]17854601
D002117CalcitriolCalcitriol results in decreased expression of CDC6 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CDC6 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of CDC6 mRNA19031421
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDC6 mRNA26159488
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of CDC6 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of CDC6 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CDC6 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDC6 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC6 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CDC6 mRNA23649840
D005047EtoposideEtoposide results in decreased expression of CDC6 mRNA16120219
D015025ZearalenoneZearalenone results in decreased expression of CDC6 mRNA27862621
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of CDC6 mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of CDC6 mRNA28329830
D005472FluorouracilFluorouracil affects the expression of CDC6 mRNA16557594
D005472FluorouracilFluorouracil results in decreased expression of CDC6 mRNA17039268
D005472FluorouracilFluorouracil results in increased expression of CDC6 mRNA16709241
D005472Fluorouracil[Leucovorin co-treated with Fluorouracil] results in increased expression of CDC6 mRNA15342418
D005472FluorouracilFluorouracil results in decreased expression of CDC6 mRNA19272435
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDC6 gene20938992
D002955Leucovorin[Leucovorin co-treated with Fluorouracil] results in increased expression of CDC6 mRNA15342418
C039281furanfuran results in increased expression of CDC6 mRNA25539665
D019833GenisteinGenistein results in increased expression of CDC6 mRNA16474171
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in decreased expression of CDC6 mRNA26941288
C492448ICG 001ICG 001 results in decreased expression of CDC6 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDC6 mRNA25613284
C544151jinfukangjinfukang results in increased expression of CDC6 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDC6 mRNA26941288
C410337K 7174K 7174 results in decreased expression of CDC6 mRNA24086573
D007649KetamineKetamine results in decreased expression of CDC6 mRNA20080153
D007840LatexLatex analog results in increased expression of CDC6 mRNA24768652
C008261lead acetatelead acetate results in decreased expression of CDC6 mRNA20542052
D008070LipopolysaccharidesLipopolysaccharides affects the expression of CDC6 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of CDC6 mRNA]28070326
D018021Lithium ChlorideLithium Chloride results in decreased expression of CDC6 mRNA17440966
D018021Lithium ChlorideLithium Chloride results in decreased expression of CDC6 protein17440966
D018021Lithium ChlorideLithium Chloride results in increased expression of CDC6 mRNA22493441
D008154LucanthoneLucanthone results in decreased expression of CDC6 mRNA21148553
C018091maduramicinmaduramicin results in increased expression of CDC6 mRNA29128925
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CDC6 mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDC6 gene20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CDC6 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDC6 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CDC6 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CDC6 mRNA24810058
C008493methylselenic acidmethylselenic acid affects the expression of CDC6 mRNA14617803
C008493methylselenic acidmethylselenic acid results in decreased expression of CDC6 mRNA11830524
D015741MetriboloneMetribolone results in increased expression of CDC6 mRNA19318562
D016685MitomycinMitomycin results in decreased expression of CDC6 mRNA24211769
C523799MRK 003MRK 003 results in decreased expression of CDC6 protein19318552
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CDC6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CDC6 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CDC6 mRNA19812364
D009538NicotineNicotine inhibits the reaction [E2F4 protein binds to CDC6 promoter]16862215
D009538NicotineNicotine inhibits the reaction [E2F5 protein binds to CDC6 promoter]16862215
D009538NicotineNicotine inhibits the reaction [RB1 protein binds to CDC6 promoter]16862215
D009538NicotineNicotine inhibits the reaction [RBL1 protein binds to CDC6 promoter]16862215
D009538NicotineNicotine inhibits the reaction [RBL2 protein binds to CDC6 promoter]16862215
D009538NicotineNicotine promotes the reaction [E2F1 protein binds to CDC6 promoter]16862215
D009538NicotineNicotine promotes the reaction [E2F2 protein binds to CDC6 promoter]16862215
D009538NicotineNicotine promotes the reaction [E2F3 protein binds to CDC6 promoter]16862215
D010100OxygenOxygen deficiency results in decreased expression of CDC6 mRNA26516004
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CDC6 mRNA25658374
D010126OzoneOzone results in increased expression of CDC6 mRNA19555225
D010278Parathion[Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA17390078
D010278ParathionParathion results in increased expression of CDC6 mRNA17622325
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC6 mRNA"25510870
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of CDC6 mRNA26678675
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CDC6 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of CDC6 mRNA19482888|2309116
D048789PhytoestrogensPhytoestrogens results in increased expression of CDC6 mRNA18310284
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDC6 mRNA19710929
D010894PiroxicamPiroxicam results in increased expression of CDC6 mRNA21858171
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of CDC6 mRNA]28070326
D010936Plant ExtractsPlant Extracts results in increased expression of CDC6 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of CDC6 mRNA16474171
D017035PravastatinPravastatin affects the expression of CDC6 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of CDC6 mRNA27225895
D011374ProgesteroneProgesterone results in decreased expression of CDC6 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of CDC6 mRNA18070364
D011374ProgesteroneProgesterone results in decreased expression of CDC6 mRNA19690047
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of CDC6 mRNA17639512
D011794QuercetinQuercetin results in decreased expression of CDC6 mRNA15309432
D011794QuercetinQuercetin results in increased expression of CDC6 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of CDC6 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CDC6 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of CDC6 mRNA15767336
C093642SB 203580SB 203580 inhibits the reaction [arsenic trioxide results in increased expression of CDC6 protein]20862710
C410733scriptaidscriptaid affects the expression of CDC6 mRNA18813790
C078903seocalcitolseocalcitol results in decreased expression of CDC6 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CDC6 mRNA23806026
D012835Silver NitrateSilver Nitrate analog results in increased expression of CDC6 mRNA22831968
D012835Silver NitrateSilver Nitrate results in increased expression of CDC6 mRNA22831968
D019821SimvastatinSimvastatin results in decreased expression of CDC6 mRNA17428261
D018038Sodium SeleniteSodium Selenite results in decreased expression of CDC6 mRNA16705456
C561322sparstolonin Bsparstolonin B results in decreased expression of CDC6 mRNA23940584
C075117squalestatin 1squalestatin 1 results in decreased expression of CDC6 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of CDC6 mRNA27225895
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CDC6 mRNA21641980
C061133tamibarotenetamibarotene results in decreased expression of CDC6 mRNA15498508
D013629TamoxifenTamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CDC6 mRNA]24758408
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of CDC6 mRNA]24758408
D013629TamoxifenTamoxifen affects the expression of CDC6 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CDC6 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CDC6 mRNA21592394
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDC6 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDC6 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDC6 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC6 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDC6 mRNA16102516
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDC6 mRNA15667827|1794274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDC6 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of CDC6 mRNA22659510
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CDC6 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CDC6 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CDC6 mRNA17494027
D024505TocopherolsTocopherols results in increased expression of CDC6 mRNA17056531
D014212TretinoinTretinoin results in decreased expression of CDC6 mRNA15498508|1624948
C012589trichostatin Atrichostatin A affects the expression of CDC6 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CDC6 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of CDC6 mRNA19140230
D014635Valproic AcidValproic Acid results in increased expression of CDC6 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of CDC6 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CDC6 gene25560391
D014750VincristineVincristine results in decreased expression of CDC6 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of CDC6 mRNA26682919
D000225AdenineAdenine results in decreased expression of CDC6 mRNA24211769
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of CDC6 mRNA"24525044
C094299ZD 9331ZD 9331 results in increased expression of CDC6 mRNA15342418

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-TAS8990175  
GO:0003688DNA replication origin binding-IBA21873635  
GO:0005515protein binding-IPI14672932  15232106  19150984  21041660  23397142  25241761  
25990725  
GO:0005524ATP binding-IEA-  
GO:0019900kinase binding-IPI21041660  
GO ID GO Term Qualifier Evidence PubMed
GO:0000076DNA replication checkpoint-TAS9566895  
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-TAS9566895  
GO:0000082G1/S transition of mitotic cell cycle-TAS-  
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TAS-  
GO:0000278mitotic cell cycle-IBA21873635  
GO:0000278mitotic cell cycle-IMP22581055  
GO:0006260DNA replication-TAS-  
GO:0006270DNA replication initiation-IEA-  
GO:0007089traversing start control point of mitotic cell cycle-TAS9566895  
GO:0008156negative regulation of DNA replication-TAS9566895  
GO:0008285negative regulation of cell proliferation-TAS9566895  
GO:0030071regulation of mitotic metaphase/anaphase transition-IMP21041660  
GO:0032467positive regulation of cytokinesis-IMP21041660  
GO:0033314mitotic DNA replication checkpoint-IBA21873635  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IEA-  
GO:0048146positive regulation of fibroblast proliferation-IEA-  
GO:0051301cell division-IEA-  
GO:0051984positive regulation of chromosome segregation-IDA21041660  
GO:1904117cellular response to vasopressin-IEA-  
GO:1904385cellular response to angiotensin-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IDA21041660  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA21041660  21383955  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolusNOTIDA21383955  
GO:0005737cytoplasm-TAS9566895  
GO:0005829cytosol-TAS-  
GO:0051233spindle midzone-IDA21041660  
KEGG ID KEGG Term
hsa04110Cell cycle
Reactome ID Reactome Term Evidence
R-HSA-1362277Transcription of E2F targets under negative control by DREAM complexTAS
R-HSA-1538133G0 and Early G1TAS
R-HSA-1640170Cell CycleTAS
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-539107Activation of E2F1 target genes at G1/STAS
R-HSA-68689CDC6 association with the ORC:origin complexTAS
R-HSA-68827CDT1 association with the CDC6:ORC:origin complexTAS
R-HSA-68867Assembly of the pre-replicative complexTAS
R-HSA-68874M/G1 TransitionTAS
R-HSA-68949Orc1 removal from chromatinTAS
R-HSA-68962Activation of the pre-replicative complexTAS
R-HSA-69002DNA Replication Pre-InitiationTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69205G1/S-Specific TranscriptionTAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28968711Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients. (2017 Oct 26)Couto PPCarcinogenesis
29328493Meta-analysis of mRNA expression profiles to identify differentially expressed genes in lung adenocarcinoma tissue from smokers and non-smokers. (2018 Mar)He XOncol Rep
19233139A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD. (2009 Apr 17)Takabatake NBiochem Biophys Res Commun