Gene: SRGAP3

9901
ARHGAP14|MEGAP|SRGAP2|WRP
SLIT-ROBO Rho GTPase activating protein 3
protein-coding
3p25.3
Ensembl:ENSG00000196220 MIM:606525 Vega:OTTHUMG00000090589 UniprotKB:O43295
NC_000003.12
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.744e-1 (AD)  4.059e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4684630chr3:9245460 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)
rs17530358chr3:9158691 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01177100chr3:9176211SRGAP32.200e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRAMD1B0.975
MYH100.963
KALRN0.961
MADD0.96
SRRM40.96
DOCK30.957
PGBD50.954
TLN20.954
PI4KA0.953
KCNMA10.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.572
RAI14-0.551
WWTR1-0.547
YES1-0.522
C9orf135-0.521
HEY2-0.519
REST-0.516
SGMS2-0.511
RAB13-0.504
MYL3-0.503

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of SRGAP3 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SRGAP3 mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRGAP3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRGAP3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SRGAP3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SRGAP3 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SRGAP3 mRNA21298039
D001280AtrazineAtrazine results in decreased expression of SRGAP3 mRNA25929836
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of SRGAP3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SRGAP3 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SRGAP3 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SRGAP3 mRNA19770486|2156981
D004958EstradiolEstradiol affects the expression of SRGAP3 mRNA25321415
D004958EstradiolEstradiol results in decreased expression of SRGAP3 mRNA26945725
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SRGAP3 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of SRGAP3 mRNA27685785
C006780bisphenol Abisphenol A results in increased methylation of SRGAP3 promoter27312807
D016572CyclosporineCyclosporine results in increased methylation of SRGAP3 promoter27989131
D003561CytarabineCytarabine results in increased expression of SRGAP3 mRNA21198554
D003907DexamethasoneDexamethasone results in increased expression of SRGAP3 mRNA23137833
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SRGAP3 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SRGAP3 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SRGAP3 mRNA27392435
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of SRGAP3 mRNA28329830
D017313FenretinideFenretinide results in increased expression of SRGAP3 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SRGAP3 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SRGAP3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SRGAP3 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SRGAP3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SRGAP3 mRNA"25554681
D009532NickelNickel results in decreased expression of SRGAP3 mRNA25583101
D010634PhenobarbitalPhenobarbital affects the expression of SRGAP3 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SRGAP3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SRGAP3 mRNA26272509
D011794QuercetinQuercetin results in increased expression of SRGAP3 mRNA21632981
C059514resveratrolresveratrol results in increased expression of SRGAP3 mRNA23137833
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SRGAP3 mRNA25895662
D012834SilverSilver results in decreased expression of SRGAP3 mRNA26551752
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SRGAP3 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SRGAP3 mRNA28922406
C012589trichostatin Atrichostatin A affects the expression of SRGAP3 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SRGAP3 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of SRGAP3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SRGAP3 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of SRGAP3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of SRGAP3 gene29154799
C088658zoledronic acidzoledronic acid results in increased expression of SRGAP3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-TAS-  
GO:0005515protein binding-IPI17500595  25819436  
GO:0048365Rac GTPase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0030336negative regulation of cell migration-IBA21873635  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-428543Inactivation of CDC42 and RAC1IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal