Gene: RBM19

9904
Mrd1
RNA binding motif protein 19
protein-coding
12q24.13-q24.21
Ensembl:ENSG00000122965 MIM:616444 Vega:OTTHUMG00000169646 UniprotKB:Q9Y4C8
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
8.377e-1 (AD)  8.061e-1 (ND)   (Frontal_Cortex)
9.648e-1 (AD)  2.001e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAU20.926
INTS30.922
ZSWIM80.918
SMPD40.918
EP4000.91
POGZ0.909
RBM50.908
STX160.906
NUMA10.904
DIDO10.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.578
OR4F29-0.544
KLRC2-0.315
MTRNR2L9-0.309
TRDN-0.298
MTRNR2L6-0.296
MTRNR2L10-0.287
OR4F16-0.268
TTLL10-AS1-0.255
KLRB1-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RBM19 mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RBM19 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RBM19 mRNA"21346803
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of RBM19 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of RBM19 mRNA]28655636
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of RBM19 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of RBM19 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of RBM19 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of RBM19 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RBM19 mRNA19770486
D001151ArsenicArsenic affects the methylation of RBM19 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RBM19 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of RBM19 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RBM19 mRNA25181051
D002330CarmustineRBM19 mRNA affects the susceptibility to Carmustine16365179
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RBM19 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RBM19 mRNA28472532
D019327Copper SulfateCopper Sulfate results in increased expression of RBM19 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of RBM19 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of RBM19 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in increased expression of RBM19 mRNA24921660
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of RBM19 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RBM19 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RBM19 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of RBM19 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of RBM19 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RBM19 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RBM19 gene20938992
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of RBM19 mRNA22634610
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RBM19 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RBM19 mRNA23086925
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RBM19 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RBM19 mRNA26011545
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of RBM19 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of RBM19 mRNA28655636
D010936Plant ExtractsPlant Extracts results in increased expression of RBM19 mRNA23557933
D011794QuercetinQuercetin results in increased expression of RBM19 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of RBM19 protein25505154
D012822Silicon DioxideSilicon Dioxide results in increased expression of RBM19 mRNA25351596
C047246temozolomideRBM19 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RBM19 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RBM19 mRNA25613284
D014212TretinoinTretinoin results in increased expression of RBM19 mRNA20488242
C057693troglitazonetroglitazone results in decreased expression of RBM19 mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of RBM19 mRNA23179753|2800136
D014635Valproic AcidValproic Acid affects the expression of RBM19 mRNA17292431
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of RBM19 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of RBM19 mRNA28655636
C025643vinclozolinvinclozolin results in increased expression of RBM19 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0007275multicellular organism development-IEA-  
GO:0040019positive regulation of embryonic development-ISS-  
GO:0045292mRNA cis splicing, via spliceosome-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-ISS-  
GO:0005694chromosome-IEA-  
GO:0005730nucleolus-IBA21873635  
GO:0005730nucleolus-IDA16027046  
GO:0005730nucleolus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0016020membrane-HDA19946888  
GO:0016607nuclear speck-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26423011Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015 Oct)Wain LVLancet Respir Med