Gene info: ID 991

Gene: CDC20

GENE ID: 991

Synonyms: CDC20A|bA276H19.3|p55CDC

Description: cell division cycle 20

Gene type: protein-coding

Location: 1p34.2

dbXrefs: Ensembl:ENSG00000117399 MIM:603618 Vega:OTTHUMG00000007420 UniprotKB:Q12834

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.185e-1 (AD) 6.140e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TMEM171	0.627
ZDHHC9	0.586
ELOVL1	0.582
TYMS	0.582
TMEM206	0.58
CDC42EP2	0.571
FAM124A	0.57
GPR62	0.561
FAM222A	0.553
NIPAL4	0.551

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MRO	-0.234
ACBD7	-0.22
MFAP5	-0.214
HCAR1	-0.212
TRDN	-0.206
TMEM190	-0.198
CYSLTR2	-0.197
NKAIN3	-0.195
RANBP3L	-0.185
KCNJ16	-0.185

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of CDC20 mRNA"	26377693
C569107	1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one	"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of CDC20 protein"	21903591
C569107	1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one	"acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of CDC20 protein]"	21903591
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CDC20 mRNA"	22698814\|2890350
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CDC20 mRNA]"	22698814
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC20 mRNA"	25510870
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDC20 mRNA"	27291303
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CDC20 mRNA"	19114083
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CDC20 mRNA"	19031421
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC20 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC20 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC20 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC20 mRNA"	25510870
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in increased expression of CDC20 mRNA	25088246
C019499	2-nitrofluorene	2-nitrofluorene results in decreased expression of CDC20 mRNA	15890375
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDC20 mRNA"	23196670
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of CDC20 mRNA	22841810
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CDC20 mRNA"	18648102
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cadmium Chloride promotes the reaction [CDC20 protein binds to CDC27 protein binds to MAD2L1 protein]]	20054826
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cadmium Chloride results in decreased expression of CDC20 protein]	20054826
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CDC20 mRNA	12419474
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CDC20 mRNA	19191707
C082164	4-methoxycinnamate methyl ester	[Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of CDC20 mRNA	19442820
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDC20 mRNA	15890375
C063261	acetylleucyl-leucyl-norleucinal	acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]	20054826
C063261	acetylleucyl-leucyl-norleucinal	acetylleucyl-leucyl-norleucinal promotes the reaction [Cadmium Chloride results in increased ubiquitination of CDC20 protein]	20054826
C110923	acetyl-valyl-isoleucyl-aspartyl-aldehyde	"acetyl-valyl-isoleucyl-aspartyl-aldehyde inhibits the reaction [1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of CDC20 protein]"	21903591
D020106	Acrylamide	Acrylamide results in increased expression of CDC20 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CDC20 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CDC20 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CDC20 mRNA	15890375
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of CDC20 mRNA	17023530
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CDC20 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of CDC20 mRNA"	22863853
C519728	archazolid B	archazolid B results in decreased expression of CDC20 mRNA	25218289
D001151	Arsenic	Arsenic results in decreased expression of CDC20 mRNA	18315880
C006632	arsenic trioxide	[arsenic trioxide co-treated with Paclitaxel] promotes the reaction [BUB1B protein binds to CDC20 protein]	19781537
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CDC20 mRNA	20862710
C015001	arsenite	arsenite results in decreased expression of CDC20 protein	17373649
C015001	arsenite	arsenite results in decreased expression of CDC20 mRNA	18929588
D001285	Atropine	Atropine results in increased expression of CDC20 mRNA	17390078
D001285	Atropine	[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA	17390078
D001374	Azacitidine	[Azacitidine co-treated with Thalidomide] affects the expression of CDC20 mRNA	18720364
D001379	Azathioprine	Azathioprine results in decreased expression of CDC20 mRNA	22623647
C547126	AZM551248	AZM551248 results in increased expression of CDC20 mRNA	22323515
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of CDC20 mRNA	26377693
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDC20 mRNA	18164116\|2129510
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of CDC20 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDC20 mRNA	20064835\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDC20 mRNA	19770486\|2156981
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC20 mRNA"	19150397\|2038263
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]	20054826
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDC20 mRNA	20061341\|2556608
D004958	Estradiol	Estradiol results in increased expression of CDC20 mRNA	16474171
D004958	Estradiol	ESR1 protein promotes the reaction [Estradiol results in increased expression of CDC20 mRNA]	25210133
D004958	Estradiol	Estradiol results in increased expression of CDC20 mRNA	25210133\|2762328
C053541	bicalutamide	bicalutamide results in decreased expression of CDC20 mRNA	15638997
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of CDC20 mRNA	27685785
C006780	bisphenol A	bisphenol A affects the expression of CDC20 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of CDC20 mRNA	29027980
C006780	bisphenol A	bisphenol A results in decreased expression of CDC20 mRNA	27979917\|2895115
C006780	bisphenol A	bisphenol A results in increased expression of CDC20 mRNA	16474171
C006780	bisphenol A	bisphenol A affects the expression of CDC20 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of CDC20 mRNA	26982218
D001761	Bleomycin	Bleomycin results in increased expression of CDC20 mRNA	26345256
D002065	Buspirone	Buspirone results in decreased expression of CDC20 mRNA	24136188
D002083	Butylated Hydroxyanisole	[propylparaben co-treated with Butylated Hydroxyanisole] results in decreased expression of CDC20 mRNA	25086368
D002087	Butyrates	Butyrates results in decreased expression of CDC20 mRNA	14674679
D002104	Cadmium	Cadmium results in decreased expression of CDC20 mRNA	21120746
D019256	Cadmium Chloride	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cadmium Chloride promotes the reaction [CDC20 protein binds to CDC27 protein binds to MAD2L1 protein]]	20054826
D019256	Cadmium Chloride	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cadmium Chloride results in decreased expression of CDC20 protein]	20054826
D019256	Cadmium Chloride	acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]	20054826
D019256	Cadmium Chloride	acetylleucyl-leucyl-norleucinal promotes the reaction [Cadmium Chloride results in increased ubiquitination of CDC20 protein]	20054826
D019256	Cadmium Chloride	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]	20054826
D019256	Cadmium Chloride	Cadmium Chloride promotes the reaction [CDC20 protein binds to CDC27 protein binds to MAD2L1 protein]	20054826
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDC20 protein	20054826
D019256	Cadmium Chloride	Cadmium Chloride results in increased ubiquitination of and results in increased degradation of CDC20 protein	20054826
D019256	Cadmium Chloride	CDC27 mutant form inhibits the reaction [Cadmium Chloride results in increased ubiquitination of and results in increased degradation of CDC20 protein]	20054826
D019256	Cadmium Chloride	MAPK14 gene mutant form inhibits the reaction [Cadmium Chloride results in increased ubiquitination of and results in increased degradation of CDC20 protein]	20054826
D019256	Cadmium Chloride	MAPK14 mutant form inhibits the reaction [Cadmium Chloride results in increased ubiquitination of and results in increased degradation of CDC20 protein]	20054826
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDC20 mRNA	20061341
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDC20 mRNA	18636176\|2599309
C040048	caffeic acid	[Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA	19442820
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CDC20 mRNA	17484886\|2733941
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CDC20 mRNA]	16006527
D002706	Chlordan	Chlordan results in increased expression of CDC20 mRNA	20403969
C100187	chloropicrin	chloropicrin results in decreased expression of CDC20 mRNA	28476498
D002737	Chloroprene	Chloroprene affects the expression of CDC20 mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDC20 gene	20938992
D003033	Coal Tar	Coal Tar results in increased expression of CDC20 mRNA	27858113
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CDC20 mRNA	19320972\|1937684
D003300	Copper	Copper results in increased expression of CDC20 mRNA	17205981
D003300	Copper	Copper results in increased expression of CDC20 mRNA	22465980
C464760	copper-1,10-phenanthroline	"copper-1,10-phenanthroline results in decreased expression of CDC20 protein"	24638265
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CDC20 mRNA	19549813
D003345	Corticosterone	Corticosterone results in decreased expression of CDC20 mRNA	15755911
C030973	cupric oxide	cupric oxide results in decreased expression of CDC20 mRNA	22077320
D003471	Cuprizone	Cuprizone results in increased expression of CDC20 mRNA	26577399
D003474	Curcumin	Curcumin results in decreased expression of CDC20 mRNA	22258452
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of CDC20 mRNA	11599041
D016572	Cyclosporine	Cyclosporine results in decreased expression of CDC20 mRNA	20106945\|2163298
D000069439	Dasatinib	Dasatinib results in decreased expression of CDC20 mRNA	20579391
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of CDC20 mRNA	24317228
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CDC20 mRNA	23640034
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone results in decreased expression of CDC20 mRNA	16940010
D003976	Diazinon	Diazinon results in increased methylation of CDC20 gene	22964155
D003976	Diazinon	Diazinon affects the expression of CDC20 mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CDC20 mRNA	28973377
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CDC20 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CDC20 mRNA	21266533
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of CDC20 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of CDC20 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of CDC20 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of CDC20 mRNA	21151649
C000944	dicrotophos	dicrotophos results in increased expression of CDC20 mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of CDC20 mRNA	26924002
D004026	Dieldrin	Dieldrin affects the expression of CDC20 mRNA	22546817
D004041	Dietary Fats	Dietary Fats affects the expression of CDC20 mRNA	19680557
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CDC20 mRNA	17854601\|2453584
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC20 mRNA]	17854601
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDC20 mRNA	18164116\|2129510
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CDC20 mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CDC20 mRNA	15766595
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CDC20 mRNA	15890375
D002117	Calcitriol	Calcitriol promotes the reaction [Testosterone results in increased expression of CDC20 mRNA]	21592394
D002117	Calcitriol	Calcitriol results in decreased expression of CDC20 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of CDC20 mRNA	21592394
D002117	Calcitriol	Testosterone promotes the reaction [Calcitriol results in increased expression of CDC20 mRNA]	21592394
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of CDC20 mRNA	15890375
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of CDC20 mRNA	26924002
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the expression of CDC20 mRNA	22302311
D004365	Drugs, Chinese Herbal	"[Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of CDC20 mRNA"	19442820
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CDC20 mRNA	14976129\|1755557
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CDC20 mRNA	17351261
D005419	Flavonoids	Flavonoids results in decreased expression of CDC20 mRNA	18035473
D016650	Fluorescein-5-isothiocyanate	Fluorescein-5-isothiocyanate binds to CDC20 protein	27129696
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of CDC20 mRNA]	15016801
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CDC20 mRNA	24657277
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDC20 gene	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of CDC20 mRNA	23649840
C070081	fulvestrant	[fulvestrant co-treated with Sirolimus] results in decreased expression of CDC20 mRNA	19016759
C070081	fulvestrant	fulvestrant results in decreased expression of CDC20 mRNA	19016759
C039281	furan	furan results in increased expression of CDC20 mRNA	25539665
D019833	Genistein	Genistein affects the expression of CDC20 mRNA	18214933
D019833	Genistein	Genistein affects the expression of CDC20 mRNA	18847459
D019833	Genistein	Genistein results in increased expression of CDC20 mRNA	16474171
D019833	Genistein	[Genistein co-treated with vinclozolin] results in decreased expression of CDC20 mRNA	23160963
D005944	Glucosamine	Glucosamine results in decreased expression of CDC20 mRNA	17109745
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of CDC20 mRNA	22634610
C080043	hexyl cinnamic aldehyde	hexyl cinnamic aldehyde affects the expression of CDC20 mRNA	22302311
D017313	Fenretinide	Fenretinide results in increased expression of CDC20 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of CDC20 mRNA	12419474
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CDC20 mRNA	25613284
C051890	irinotecan	CDC20 protein results in increased susceptibility to irinotecan	16734730
C051890	irinotecan	irinotecan affects the expression of CDC20 mRNA	20097248
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of CDC20 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of CDC20 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of CDC20 mRNA	24086573
D007840	Latex	Latex analog results in increased expression of CDC20 mRNA	24768652
C045463	leflunomide	leflunomide results in decreased expression of CDC20 mRNA	24136188
D008154	Lucanthone	Lucanthone results in decreased expression of CDC20 mRNA	21148553
D008294	Malathion	Malathion results in decreased expression of CDC20 mRNA	18214805
D008345	Manganese	Manganese results in increased expression of CDC20 mRNA	18284614
D008701	Methapyrilene	Methapyrilene results in increased expression of CDC20 mRNA	15890375
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDC20 gene	20938992
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CDC20 mRNA	24657277
D008727	Methotrexate	Methotrexate results in decreased expression of CDC20 mRNA	24657277
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of CDC20 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CDC20 mRNA	20061341
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CDC20 mRNA	23649840
C008493	methylselenic acid	methylselenic acid affects the expression of CDC20 mRNA	14617803
D016685	Mitomycin	Mitomycin results in decreased expression of CDC20 mRNA	25270620
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of CDC20 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of CDC20 mRNA	25102026
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CDC20 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CDC20 mRNA"	25554681
C031721	naphthalene	naphthalene results in increased expression of CDC20 mRNA	18978301
D009532	Nickel	Nickel binds to CDC20 protein	16497171
C022838	nickel chloride	nickel chloride affects the expression of CDC20 mRNA	22546817
C017557	nickel subsulfide	nickel subsulfide results in increased expression of CDC20 mRNA	24952340
C012655	nimesulide	nimesulide results in decreased expression of CDC20 mRNA	24136188
C025589	ochratoxin A	ochratoxin A results in increased expression of CDC20 mRNA	19237604
C030110	oxaliplatin	oxaliplatin results in decreased expression of CDC20 mRNA	25729387
D010100	Oxygen	Oxygen results in decreased expression of CDC20 mRNA	27103661
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CDC20 mRNA	25658374
D010126	Ozone	Ozone results in increased expression of CDC20 mRNA	19555225
D017239	Paclitaxel	[arsenic trioxide co-treated with Paclitaxel] promotes the reaction [BUB1B protein binds to CDC20 protein]	19781537
C500026	palbociclib	palbociclib results in decreased expression of CDC20 mRNA	22869556
D000073878	Palm Oil	Palm Oil affects the expression of CDC20 mRNA	19680557
D010269	Paraquat	Paraquat results in increased expression of CDC20 mRNA	26345256
D010269	Paraquat	Paraquat results in decreased expression of CDC20 mRNA	18198484
D010278	Parathion	[Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA	17390078
D010278	Parathion	Parathion results in increased expression of CDC20 mRNA	17390078
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC20 mRNA"	25510870
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CDC20 mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CDC20 mRNA	18467677
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of CDC20 mRNA]	18467677
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of CDC20 mRNA	26678675
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CDC20 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of CDC20 mRNA	19363144\|1948288
D009764	o-Phthalaldehyde	o-Phthalaldehyde affects the expression of CDC20 mRNA	22302311
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of CDC20 mRNA	15890375
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDC20 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of CDC20 mRNA	17950772\|1830175
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of CDC20 mRNA]	21318169
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of CDC20 mRNA]	17950772\|1846767
C006253	pirinixic acid	pirinixic acid results in increased expression of CDC20 mRNA	15890375\|1916217
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in increased expression of CDC20 mRNA	16474171
D011285	Pregnenolone Carbonitrile	NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of CDC20 mRNA]	22698814
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of CDC20 mRNA	22698814
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of CDC20 mRNA	19162173\|2131816
D011374	Progesterone	Progesterone results in decreased expression of CDC20 mRNA	23012394
D011374	Progesterone	Progesterone results in increased expression of CDC20 mRNA	18070364
D011374	Progesterone	Progesterone results in increased expression of CDC20 mRNA	19693291
D011374	Progesterone	Progesterone results in decreased expression of CDC20 mRNA	20726854
C045950	propiconazole	propiconazole results in increased expression of CDC20 mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in decreased expression of CDC20 mRNA	26079696
C006068	propylparaben	[propylparaben co-treated with Butylated Hydroxyanisole] results in decreased expression of CDC20 mRNA	25086368
D011441	Propylthiouracil	Propylthiouracil results in increased expression of CDC20 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of CDC20 mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of CDC20 mRNA	21632981\|2372791
C031389	resorcinol	resorcinol results in decreased expression of CDC20 mRNA	22623647
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of CDC20 mRNA"	16251409
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CDC20 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CDC20 mRNA	26345256
D020123	Sirolimus	[fulvestrant co-treated with Sirolimus] results in decreased expression of CDC20 mRNA	19016759
C009277	sodium arsenate	sodium arsenate results in decreased expression of CDC20 mRNA	12727804
C017947	sodium arsenite	sodium arsenite results in decreased expression of CDC20 mRNA	12727804
C017947	sodium arsenite	sodium arsenite results in decreased expression of CDC20 mRNA	19822182
C016104	sodium bichromate	sodium bichromate results in increased expression of CDC20 mRNA	22561333
D012999	Soman	Soman results in increased expression of CDC20 mRNA	19281266
D053260	Soot	Soot results in increased expression of CDC20 mRNA	22461453\|2655175
C013698	tallow	tallow affects the expression of CDC20 mRNA	19680557
D013629	Tamoxifen	Tamoxifen affects the expression of CDC20 mRNA	17555576
D013739	Testosterone	Calcitriol promotes the reaction [Testosterone results in increased expression of CDC20 mRNA]	21592394
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of CDC20 mRNA	21592394
D013739	Testosterone	Testosterone promotes the reaction [Calcitriol results in increased expression of CDC20 mRNA]	21592394
D013739	Testosterone	Testosterone results in decreased expression of CDC20 mRNA	21592394
D013739	Testosterone	Testosterone results in increased expression of CDC20 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDC20 mRNA	21802500
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDC20 mRNA]	16891777
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CDC20 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDC20 mRNA	16891777
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CDC20 mRNA	19770486
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CDC20 mRNA	19031421
D013755	Tetradecanoylphorbol Acetate	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CDC20 mRNA	16979875
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CDC20 mRNA	25613284
D013792	Thalidomide	[Azacitidine co-treated with Thalidomide] affects the expression of CDC20 mRNA	18720364
D019284	Thapsigargin	[Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of CDC20 mRNA	19442820
D019284	Thapsigargin	[Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA	19442820
D019284	Thapsigargin	"[Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of CDC20 mRNA"	19442820
D019284	Thapsigargin	Thapsigargin results in increased expression of CDC20 mRNA	19442820
D013853	Thioacetamide	Thioacetamide results in increased expression of CDC20 mRNA	22659510
C009495	titanium dioxide	titanium dioxide results in increased expression of CDC20 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CDC20 mRNA	25447457
D019772	Topotecan	Topotecan results in decreased expression of CDC20 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of CDC20 mRNA	23724009
D014241	Trichloroethylene	Trichloroethylene results in increased expression of CDC20 mRNA	25549359
C012589	trichostatin A	trichostatin A results in decreased expression of CDC20 mRNA	23770000
C015559	trimellitic anhydride	trimellitic anhydride affects the expression of CDC20 mRNA	22302311
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CDC20 mRNA	19042947
C057693	troglitazone	troglitazone results in decreased expression of CDC20 mRNA	19140230
C080163	trovafloxacin	trovafloxacin results in decreased expression of CDC20 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of CDC20 mRNA	25979313
D014635	Valproic Acid	Valproic Acid affects the expression of CDC20 mRNA	17292431
C025643	vinclozolin	[Genistein co-treated with vinclozolin] results in decreased expression of CDC20 mRNA	23160963
C025643	vinclozolin	vinclozolin results in decreased expression of CDC20 mRNA	15686871
D015032	Zinc	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CDC20 mRNA	16979875
D015032	Zinc	Zinc deficiency results in decreased expression of CDC20 mRNA	12888634
D015032	Zinc	Zinc deficiency results in increased expression of CDC20 mRNA	22171008
C088658	zoledronic acid	zoledronic acid results in decreased expression of CDC20 mRNA	20977926\|2471476

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	11030144 11459826 14743218 15525512 16525508 17443180 17443186 17719540 18022367 18318601 18794143 19143472 19282672 19407811 20212161 20360068 20951947 21041666 21300909 21407176 21725316 21772247 22000412 22014574 22322943 22340593 23288039 24581499 24781523 25241761 25383541 25852190 26496610
GO:0008022	protein C-terminus binding	-	IPI	10700282
GO:0010997	anaphase-promoting complex binding	-	IEA	-
GO:0019899	enzyme binding	-	IPI	17443180
GO:0042826	histone deacetylase binding	-	IEA	-
GO:0097027	ubiquitin-protein transferase activator activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007064	mitotic sister chromatid cohesion	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0016567	protein ubiquitination	-	IEA	-
GO:0016579	protein deubiquitination	-	TAS	-
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	IDA	17443180
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	-
GO:0031915	positive regulation of synaptic plasticity	-	ISS	-
GO:0040020	regulation of meiotic nuclear division	-	IEA	-
GO:0050773	regulation of dendrite development	-	IEA	-
GO:0051301	cell division	-	IEA	-
GO:0090129	positive regulation of synapse maturation	-	ISS	-
GO:0090307	mitotic spindle assembly	-	IEA	-
GO:1904668	positive regulation of ubiquitin protein ligase activity	-	IDA	11459826

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000922	spindle pole	-	IEA	-
GO:0005634	nucleus	-	IDA	-
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005680	anaphase-promoting complex	colocalizes_with	IDA	11459825
GO:0005813	centrosome	-	IEA	-
GO:0005819	spindle	-	TAS	7513050
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0048471	perinuclear region of cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04110	Cell cycle
hsa04114	Oocyte meiosis
hsa04120	Ubiquitin mediated proteolysis

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	TAS
R-HSA-141424	Amplification of signal from the kinetochores	TAS
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	TAS
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-168256	Immune System	TAS
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	TAS
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	TAS
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	TAS
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	TAS
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	TAS
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	TAS
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	TAS
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	TAS
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-176417	Phosphorylation of Emi1	TAS
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	TAS
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	TAS
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-453276	Regulation of mitotic cell cycle	TAS
R-HSA-5663220	RHO GTPases Activate Formins	TAS
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-68877	Mitotic Prometaphase	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69618	Mitotic Spindle Checkpoint	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26622675	Pathogenic mechanisms of lung adenocarcinoma in smokers and non-smokers determined by gene expression interrogation. (2015 Sep)	Hu Y	Oncol Lett
29328493	Meta-analysis of mRNA expression profiles to identify differentially expressed genes in lung adenocarcinoma tissue from smokers and non-smokers. (2018 Mar)	He X	Oncol Rep
25514196	Comprehensive analysis of genes, pathways, and TFs in nonsmoking Taiwan females with lung cancer. (2015 Mar)	Lv M	Exp Lung Res
21439932	Cigarette smoke suppresses the ubiquitin-dependent degradation of OLC1. (2011 Apr 22)	Zhang X	Biochem Biophys Res Commun