Gene: RABGAP1L

9910
HHL|TBC1D18
RAB GTPase activating protein 1 like
protein-coding
1q25.1
Ensembl:ENSG00000152061 MIM:609238 Vega:OTTHUMG00000034899 UniprotKB:B7ZAP0
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.076e-1 (AD)  3.118e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3753563chr1:174954209 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDFIP20.931
BCAP290.931
LPGAT10.93
C10orf880.93
RUFY30.93
PRKACB0.929
USP330.927
PIK3CB0.926
FEM1B0.926
CDC270.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.485
OR4F29-0.469
WDR38-0.464
RHOD-0.44
EVC2-0.428
ASB4-0.418
MSX1-0.416
CYP11A1-0.406
SIX5-0.406
LRAT-0.405

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of RABGAP1L mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RABGAP1L mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RABGAP1L mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RABGAP1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RABGAP1L mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RABGAP1L protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RABGAP1L mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RABGAP1L gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RABGAP1L mRNA19770486
D001151ArsenicArsenic affects the methylation of RABGAP1L gene25304211
C487081belinostatbelinostat results in increased expression of RABGAP1L mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of RABGAP1L mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RABGAP1L mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RABGAP1L mRNA15034205|1977048
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of RABGAP1L mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RABGAP1L mRNA"26238291
D004958EstradiolEstradiol affects the expression of RABGAP1L mRNA14699072
D004958EstradiolEstradiol results in decreased expression of RABGAP1L mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of RABGAP1L mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of RABGAP1L gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of RABGAP1L mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of RABGAP1L mRNA20883709
D002220CarbamazepineCarbamazepine affects the expression of RABGAP1L mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RABGAP1L mRNA17484886
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RABGAP1L mRNA"27188386
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of RABGAP1L mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of RABGAP1L mRNA18353800
D019327Copper SulfateCopper Sulfate results in decreased expression of RABGAP1L mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of RABGAP1L mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of RABGAP1L mRNA19770486
D013759DronabinolDronabinol results in increased expression of RABGAP1L mRNA16597638
D002945CisplatinCisplatin results in decreased expression of RABGAP1L mRNA27594783
D002945CisplatinCisplatin results in decreased expression of RABGAP1L mRNA22023808
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of RABGAP1L mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of RABGAP1L mRNA19467301
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of RABGAP1L mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RABGAP1L mRNA]17942915
D002117CalcitriolCalcitriol results in increased expression of RABGAP1L mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of RABGAP1L mRNA25380136
D004237DiuronDiuron results in decreased expression of RABGAP1L mRNA21551480
C118739entinostatentinostat results in increased expression of RABGAP1L mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RABGAP1L mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RABGAP1L mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of RABGAP1L mRNA23649840
C065180fluvastatin[zoledronic acid co-treated with fluvastatin] results in increased expression of RABGAP1L mRNA16996129
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of RABGAP1L mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of RABGAP1L mRNA23649840
D005839GentamicinsGentamicins results in increased expression of RABGAP1L mRNA22061828
D017313FenretinideFenretinide results in decreased expression of RABGAP1L mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of RABGAP1L mRNA18951874
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RABGAP1L mRNA23086925
D007854LeadLead affects the expression of RABGAP1L mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of RABGAP1L mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RABGAP1L mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RABGAP1L mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of RABGAP1L mRNA"26251327
C523799MRK 003RABGAP1L results in increased susceptibility to MRK 00319903844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of RABGAP1L mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RABGAP1L mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RABGAP1L mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of RABGAP1L mRNA19812364
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of RABGAP1L mRNA26272509
C016030pantogabpantogab results in decreased expression of RABGAP1L mRNA17379144
D010634PhenobarbitalPhenobarbital affects the expression of RABGAP1L mRNA23091169
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of RABGAP1L mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of RABGAP1L mRNA20813756|2381119
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RABGAP1L mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RABGAP1L mRNA22079256
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in decreased expression of RABGAP1L mRNA19194470
D011794QuercetinQuercetin affects the expression of RABGAP1L mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of RABGAP1L mRNA21632981
C059514resveratrolresveratrol results in decreased expression of RABGAP1L mRNA25888808
C009277sodium arsenatesodium arsenate results in increased expression of RABGAP1L mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of RABGAP1L protein21925251
C017947sodium arsenitesodium arsenite results in increased expression of RABGAP1L mRNA20883709
C016104sodium bichromatesodium bichromate affects the expression of RABGAP1L mRNA22110744
D012999SomanSoman results in decreased expression of RABGAP1L mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RABGAP1L mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RABGAP1L mRNA24680724
C009495titanium dioxidetitanium dioxide results in increased expression of RABGAP1L mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of RABGAP1L mRNA28065790
D014212TretinoinTretinoin results in decreased expression of RABGAP1L mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of RABGAP1L mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of RABGAP1L mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RABGAP1L mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RABGAP1L mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RABGAP1L mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RABGAP1L mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of RABGAP1L mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of RABGAP1L mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of RABGAP1L mRNA15901671
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RABGAP1L gene25560391
C111237vorinostatvorinostat results in decreased expression of RABGAP1L mRNA27188386
C088658zoledronic acid[zoledronic acid co-treated with fluvastatin] results in increased expression of RABGAP1L mRNA16996129
C088658zoledronic acidzoledronic acid results in decreased expression of RABGAP1L protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005096GTPase activator activity-IDA16923123  
GO:0017137Rab GTPase binding-IBA21873635  
GO:0017137Rab GTPase binding-IDA16923123  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0006897endocytosis-IEA-  
GO:0007049cell cycle-IEA-  
GO:0032880regulation of protein localization-IDA16923123  
GO:0090630activation of GTPase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16923123  
GO:0005769early endosome-IDA16923123  
GO:0005794Golgi apparatus-IDA16923123  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal