Gene: MFN2

9927
CMT2A|CMT2A2|CMT2A2A|CMT2A2B|CPRP1|HMSN6A|HSG|MARF
mitofusin 2
protein-coding
1p36.22
Ensembl:ENSG00000116688 MIM:608507 Vega:OTTHUMG00000002392 UniprotKB:O95140
NG_007945.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.588e-1 (AD)  1.384e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM168B0.96
BCL2L20.954
DCTN10.951
SNX120.946
FAM219A0.942
GNL10.942
NFE2L10.941
SERINC30.938
KLC10.935
DYNC1H10.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.767
OR4F5-0.732
MTRNR2L6-0.325
MTRNR2L10-0.318
MTRNR2L9-0.307
SIX1-0.302
GJB2-0.284
IL24-0.282
CXCR2-0.278
RNF135-0.274

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C47781915-deoxyprostaglandin J215-deoxyprostaglandin J2 results in decreased expression of MFN2 protein20678484
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MFN2 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of MFN2 mRNA"21346803
C0423754-diphenylacetoxy-1,1-dimethylpiperidinium"4-diphenylacetoxy-1,1-dimethylpiperidinium results in decreased expression of MFN2 protein"27491814
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of MFN2 mRNA]"17438283
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in decreased expression of MFN2 protein"27491814
D000082AcetaminophenAcetaminophen results in decreased expression of MFN2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of MFN2 mRNA17562736
C027696acipimoxacipimox results in increased expression of MFN2 mRNA25352640
D000255Adenosine TriphosphateMFN2 results in decreased susceptibility to Adenosine Triphosphate deficiency22292091
D000496AlloxanAlloxan results in decreased expression of MFN2 protein28483572
D000496Alloxanimisopasem manganese inhibits the reaction [Alloxan results in decreased expression of MFN2 protein]28483572
C103505AM 251AM 251 results in decreased expression of MFN2 mRNA16500647
D000638AmiodaroneAmiodarone results in increased expression of MFN2 mRNA24489787
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MFN2 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MFN2 mRNA"17331233
D001386AzidesMFN2 protein inhibits the reaction [Azides results in increased activity of BAX protein]21160028
D001386AzidesMFN2 protein results in decreased susceptibility to Azides21160028
C006780bisphenol Abisphenol A results in increased expression of MFN2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MFN2 gene28505145
D001786Blood Glucose[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of MFN2 protein28477916
D001786Blood Glucosegenipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of MFN2 protein]28477916
C018475butyraldehydebutyraldehyde results in decreased expression of MFN2 mRNA26079696
D002104CadmiumCadmium results in increased expression of MFN2 mRNA25388156
C055494caffeic acid phenethyl ester[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of MFN2 mRNA28223344
C055494caffeic acid phenethyl esterGW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of MFN2 mRNA]28223344
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of MFN2 protein26882442
D002251Carbon TetrachlorideMelatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN2 protein]26882442
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneBECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein]24879156
D002258Carbonyl Cyanide m-Chlorophenyl HydrazoneCarbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of and results in increased ubiquitination of MFN2 protein24879156
C018021cobaltous chloridecobaltous chloride affects the expression of MFN2 mRNA alternative form19320972
D003300CopperCopper results in decreased expression of MFN2 mRNA26293553
D016572CyclosporineCyclosporine results in increased methylation of MFN2 promoter27989131
D016572CyclosporineCyclosporine results in decreased expression of MFN2 protein23347876
D016572CyclosporineVitamin E inhibits the reaction [Cyclosporine results in decreased expression of MFN2 protein]23347876
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MFN2 mRNA]27941970
D002945CisplatinMFN2 protein inhibits the reaction [Cisplatin results in increased activity of BAX protein]21160028
D002945CisplatinMFN2 protein results in decreased susceptibility to Cisplatin21160028
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MFN2 mRNA26924002
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of MFN2 mRNA18313992
D004041Dietary Fats[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of MFN2 mRNA28223344
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of MFN2 mRNA28433925
D004041Dietary FatsGW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of MFN2 mRNA]28223344
D004041Dietary Fats[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA28223344
D004041Dietary Fatstauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA]28223344
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of MFN2 mRNA28433925
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MFN2 mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate affects the expression of MFN2 mRNA26924002
D004317DoxorubicinDoxorubicin results in increased expression of MFN2 mRNA28710503
D004317DoxorubicinLovastatin inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA]28710503
D004317DoxorubicinNSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA]28710503
D004317Doxorubicin[resveratrol co-treated with Doxorubicin] results in increased expression of MFN2 protein23695218
D004317DoxorubicinDoxorubicin results in decreased expression of MFN2 mRNA19915844
D004317DoxorubicinDoxorubicin results in decreased expression of MFN2 protein26678157
C070609EMD 53998EMD 53998 analog results in decreased expression of MFN2 mRNA24977338
C118739entinostatentinostat results in decreased expression of MFN2 mRNA27188386
D000431EthanolEthanol results in increased degradation of MFN2 protein25460735
D000431EthanolNR1H4 gene mutant form inhibits the reaction [Ethanol results in increased degradation of MFN2 protein]25460735
D015025ZearalenoneZearalenone results in increased expression of MFN2 mRNA19371625
D018120FinasterideFinasteride results in increased expression of MFN2 mRNA24136188
D005472FluorouracilFluorouracil affects the expression of MFN2 mRNA16584549
D005485FlutamideFlutamide results in increased expression of MFN2 mRNA24136188
C007834genipingenipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of MFN2 protein]28477916
D019833GenisteinGenistein results in increased expression of MFN2 mRNA19371625
D005839GentamicinsGentamicins results in increased expression of MFN2 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of MFN2 mRNA24136188
C412815GW 4064GW 4064 inhibits the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in decreased expression of MFN2 mRNA]28223344
C121876imisopasem manganeseimisopasem manganese inhibits the reaction [Alloxan results in decreased expression of MFN2 protein]28483572
C121876imisopasem manganeseimisopasem manganese results in decreased expression of MFN2 protein28483572
D007545IsoproterenolIsoproterenol results in decreased expression of MFN2 protein27491814
D008044LinuronLinuron results in decreased expression of MFN2 mRNA28705778
D008148LovastatinLovastatin inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA]28710503
C025340manganese chloridemanganese chloride results in decreased expression of MFN2 mRNA28539244
C025340manganese chloridemanganese chloride results in decreased expression of MFN2 protein28539244
D008550MelatoninMelatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN2 protein]26882442
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MFN2 protein25809596
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MFN2 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MFN2 mRNA26924002
C097760N-palmitoylsphingosine[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA28223344
C097760N-palmitoylsphingosineN-palmitoylsphingosine results in increased expression of MFN2 mRNA28223344
C097760N-palmitoylsphingosinetauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA]28223344
C487513NSC 23766NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA]28710503
D019319Okadaic AcidOkadaic Acid results in increased expression of MFN2 protein26732598
C016340o,p'-DDT"o,p'-DDT results in increased expression of MFN2 mRNA"19371625
D010100Oxygen[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of MFN2 protein28477916
D010100Oxygengenipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of MFN2 protein]28477916
D052638Particulate MatterParticulate Matter results in increased expression of MFN2 mRNA25560372
D052638Particulate MatterParticulate Matter results in increased expression of MFN2 protein25560372
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MFN2 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MFN2 protein28288859
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MFN2 protein26879310
D010656PhenylephrinePhenylephrine results in decreased expression of MFN2 mRNA17499311
C006253pirinixic acidpirinixic acid results in increased expression of MFN2 mRNA18301758
C059514resveratrolresveratrol results in increased expression of MFN2 mRNA19371625
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in increased expression of MFN2 mRNA]"17438283
C059514resveratrol[resveratrol co-treated with Doxorubicin] results in increased expression of MFN2 protein23695218
C059514resveratrolresveratrol results in increased expression of MFN2 mRNA17438283
C059514resveratrolresveratrol inhibits the reaction [Rotenone results in decreased expression of MFN2 mRNA]26770656
C059514resveratrolresveratrol inhibits the reaction [Rotenone results in decreased expression of MFN2 protein]26770656
D012402RotenoneRotenone results in decreased expression of MFN2 protein24792327
D012402RotenoneRotenone results in decreased expression of MFN2 mRNA23186747
D012402Rotenoneresveratrol inhibits the reaction [Rotenone results in decreased expression of MFN2 mRNA]26770656
D012402Rotenoneresveratrol inhibits the reaction [Rotenone results in decreased expression of MFN2 protein]26770656
D012402RotenoneRotenone results in decreased expression of MFN2 mRNA26770656
D012402RotenoneRotenone results in decreased expression of MFN2 protein26770656
D013629TamoxifenTamoxifen results in decreased expression of MFN2 mRNA17555576
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA]28223344
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MFN2 mRNA21570461
D019284ThapsigarginThapsigargin results in increased expression of MFN2 mRNA28223344
D014212TretinoinTretinoin results in increased expression of MFN2 mRNA17151820
D014212TretinoinTretinoin results in increased expression of MFN2 protein17151820
D014241TrichloroethyleneTrichloroethylene results in decreased expression of MFN2 mRNA19448997
D014810Vitamin EVitamin E inhibits the reaction [Cyclosporine results in decreased expression of MFN2 protein]23347876
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of MFN2 mRNA18313992
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MFN2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0005515protein binding-IPI17121834  23620051  24282027  27059175  
GO:0005525GTP binding-IEA-  
GO:0031625ubiquitin protein ligase binding-IPI16936636  
GO ID GO Term Qualifier Evidence PubMed
GO:0001825blastocyst formation-IEA-  
GO:0006626protein targeting to mitochondrion-IDA11181170  
GO:0006915apoptotic process-IEA-  
GO:0006986response to unfolded protein-IEA-  
GO:0007006mitochondrial membrane organization-IDA11181170  
GO:0007050cell cycle arrestNOTISS-  
GO:0007596blood coagulation-TAS-  
GO:0008053mitochondrial fusion-IBA21873635  
GO:0008053mitochondrial fusion-IMP23921378  
GO:0008053mitochondrial fusion-ISS-  
GO:0008053mitochondrial fusion-NAS11181170  
GO:0016236macroautophagy-TAS-  
GO:0034497protein localization to phagophore assembly site-IDA23455425  
GO:0046580negative regulation of Ras protein signal transduction-IDA15322553  
GO:0048593camera-type eye morphogenesis-IEA-  
GO:0048662negative regulation of smooth muscle cell proliferation-ISS-  
GO:0051646mitochondrion localization-IBA21873635  
GO:0051646mitochondrion localization-IDA11181170  
GO:0061734parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization-ISS-  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IMP27640178  
GO:1905461positive regulation of vascular associated smooth muscle cell apoptotic process-IMP27640178  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA11181170  20871098  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005829cytosol-ISS-  
GO:0015630microtubule cytoskeleton-IEA-  
GO:0031306intrinsic component of mitochondrial outer membrane-IBA21873635  
GO:0031306intrinsic component of mitochondrial outer membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-5205647MitophagyTAS
R-HSA-5205685Pink/Parkin Mediated MitophagyTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24088173Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells. (2013 Oct 2)Hoffmann RFRespir Res