Gene: CDC25A

993
CDC25A2
cell division cycle 25A
protein-coding
3p21.31
Ensembl:ENSG00000164045 MIM:116947 Vega:OTTHUMG00000133535 UniprotKB:P30304
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.444e-1 (AD)  2.833e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3731539chr3:48167996 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POU4F10.628
TXNRD10.624
SEC61A10.595
FICD0.587
LRRC150.584
ODC10.583
UMPS0.577
PTPN90.572
CHRNB40.568
DNAJC30.568

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.252
THEMIS-0.237
TMEM244-0.227
KRT6A-0.224
ISLR-0.221
OR4F29-0.219
AP1M2-0.212
SULT2B1-0.21
SMYD1-0.208
HS3ST4-0.206

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D inhibits the reaction [HDAC2 protein binds to CDC25A enhancer]"23112173
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D inhibits the reaction [MXD1 protein binds to CDC25A enhancer]"23112173
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D inhibits the reaction [MYC protein binds to CDC25A enhancer]"23112173
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D inhibits the reaction [SIN3A protein binds to CDC25A enhancer]"23112173
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D inhibits the reaction [VDR protein binds to CDC25A enhancer]"23112173
C0979491,25-dihydroxyvitamin D"1,25-dihydroxyvitamin D results in decreased expression of CDC25A mRNA"23112173
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased expression of CDC25A mRNA"21530604
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of CDC25A mRNA"20453058
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDC25A mRNA"26988655
C4465202-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone"2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone results in decreased expression of CDC25A"16077967
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased expression of CDC25A protein"26451628
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDC25A mRNA"19167446
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of CDC25A mRNA"20638727
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of CDC25A protein20469912
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of CDC25A protein20469912
C0059753,4-dihydroxyphenylethanol"3,4-dihydroxyphenylethanol results in decreased expression of CDC25A mRNA"12482581
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CDC25A mRNA12419474
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CDC25A mRNA19191707
C5805985-OH-BDE-475-OH-BDE-47 results in increased expression of CDC25A mRNA26988655
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of CDC25A mRNA"19936915
C072876A 771726A 771726 results in decreased expression of CDC25A protein19174558
D000082AcetaminophenAcetaminophen results in increased expression of CDC25A mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of CDC25A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDC25A mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDC25A mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of CDC25A mRNA19774075
C006632arsenic trioxidearsenic trioxide results in increased expression of CDC25A mRNA20862710|2325547
C006632arsenic trioxidearsenic trioxide results in increased expression of CDC25A protein23255470
D001241AspirinAspirin results in decreased expression of CDC25A mRNA20457246
D001280AtrazineAtrazine results in increased expression of CDC25A mRNA25929836
D001280AtrazineAtrazine results in decreased expression of CDC25A mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of CDC25A mRNA22623647
C447119bazedoxifenebazedoxifene results in decreased expression of CDC25A mRNA19914376
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CDC25A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased phosphorylation of CDC25A protein19464357
D001564Benzo(a)pyreneCLSPN mRNA affects the reaction [Benzo(a)pyrene results in decreased phosphorylation of CDC25A protein]19464357
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC25A mRNA"20382639
D004958EstradiolEstradiol results in increased expression of CDC25A mRNA24758408
D004958EstradiolEstradiol results in increased expression of CDC25A protein9705214
D004958Estradiol[Estradiol results in increased expression of CDC25A protein] which results in decreased phosphorylation of CDK2 protein9705214
D004958Estradiol[Estradiol results in increased expression of CDC25A protein] which results in decreased phosphorylation of CDK4 protein9705214
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25A mRNA]24758408
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of CDC25A mRNA"20162321
C006780bisphenol Abisphenol A results in decreased expression of CDC25A mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of CDC25A mRNA25181051
C471992bosutinibbosutinib results in decreased expression of CDC25A protein17129604
C471992bosutinibImatinib Mesylate promotes the reaction [bosutinib results in decreased expression of CDC25A protein]17129604
C584509C646 compoundC646 compound results in decreased expression of CDC25A mRNA26191083
D002185CannabidiolCannabidiol results in decreased expression of CDC25A mRNA21542829
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CDC25A mRNA16934159
C022990chromic chloridechromic chloride results in increased expression of CDC25A mRNA12128095
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of CDC25A mRNA27793765
D003042CocaineCocaine results in increased expression of CDC25A mRNA17898221
D003078ColchicineColchicine results in decreased expression of CDC25A mRNA24211769
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CDC25A mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of CDC25A mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDC25A mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CDC25A mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CDC25A mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CDC25A mRNA19159671|2010694
D000069439DasatinibDasatinib results in decreased expression of CDC25A mRNA20579391
D003630DaunorubicinDaunorubicin results in increased expression of CDC25A mRNA12656675
C014347decitabinedecitabine results in increased expression of CDC25A mRNA27915011
D003976DiazinonDiazinon affects the expression of CDC25A mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDC25A mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CDC25A mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CDC25A mRNA24211769
D002945CisplatinCisplatin results in increased expression of CDC25A mRNA27594783
D002945CisplatinCisplatin results in increased phosphorylation of CDC25A protein22006019
D004006DichlorvosDichlorvos results in increased expression of CDC25A mRNA24369695
D004006DichlorvosDichlorvos results in increased expression of CDC25A protein24369695
D004006DichlorvosTEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDC25A mRNA]24369695
D004006DichlorvosTEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDC25A protein]24369695
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CDC25A mRNA26924002
C014476diethyl maleatediethyl maleate results in increased expression of CDC25A mRNA21161181
C534866digalloylresveratroldigalloylresveratrol results in increased phosphorylation of and results in increased degradation of CDC25A protein23943154
D002117CalcitriolCalcitriol results in decreased expression of CDC25A mRNA16002434
C024629dimethyl phthalatedimethyl phthalate affects the expression of CDC25A mRNA26924002
D004317DoxorubicinDoxorubicin results in increased expression of CDC25A mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CDC25A mRNA]27181935
C118739entinostatentinostat results in decreased expression of CDC25A mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CDC25A mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDC25A mRNA17942748|2409603
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC25A mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDC25A mRNA16174780|2409603
D005047EtoposideEtoposide results in decreased expression of CDC25A mRNA24211769
D011345FenofibrateFenofibrate results in increased expression of CDC25A mRNA17264098
D005472FluorouracilFluorouracil results in decreased expression of CDC25A mRNA16510598
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of CDC25A mRNA]27181935
C039281furanfuran results in increased expression of CDC25A mRNA22079235
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of CDC25A mRNA22634610
D006247HarmineHarmine results in increased expression of CDC25A mRNA25751815
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in decreased expression of CDC25A protein"21500194
D017313FenretinideFenretinide results in increased expression of CDC25A mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CDC25A mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CDC25A mRNA12419474
D006918HydroxyureaHydroxyurea results in increased expression of CDC25A mRNA12929121
C492448ICG 001ICG 001 results in decreased expression of CDC25A mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [bosutinib results in decreased expression of CDC25A protein]17129604
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [wortmannin results in decreased expression of CDC25A protein]17129604
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDC25A mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CDC25A mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CDC25A mRNA27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDC25A mRNA21889194|2479639
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CDC25A mRNA24231268
C038753leptomycin Bleptomycin B results in decreased expression of CDC25A mRNA20803015
C541528licochalcone Blicochalcone B results in decreased expression of CDC25A protein24384411
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CDC25A mRNA12057914
D008727MethotrexateMethotrexate results in increased degradation of CDC25A protein22484375
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CDC25A mRNA23649840
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDC25A mRNA]12710931
C008493methylselenic acidmethylselenic acid affects the expression of CDC25A mRNA14617803
C008493methylselenic acidmethylselenic acid results in decreased expression of CDC25A mRNA11830524
C008493methylselenic acidmethylselenic acid results in decreased expression of CDC25A protein11830524
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CDC25A mRNA20024957
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CDC25A mRNA26924002
C500085muraglitazarmuraglitazar results in increased expression of CDC25A mRNA21515302
D009151Mustard GasMustard Gas results in decreased expression of CDC25A mRNA25102026
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of CDC25A mRNA"25461557
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDC25A mRNA"15585362
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CDC25A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CDC25A mRNA"25554681
D009285NaphthoquinonesNaphthoquinones analog results in decreased activity of CDC25A protein15582411
D019888NelfinavirNelfinavir results in increased degradation of CDC25A protein17283158
D019888Nelfinavir[Nelfinavir results in increased degradation of CDC25A protein] which results in decreased activity of CDK2 protein17283158
D009532NickelNickel results in increased expression of CDC25A mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of CDC25A mRNA22546817
D009538NicotineNicotine inhibits the reaction [E2F4 protein binds to CDC25A promoter]16862215
D009538NicotineNicotine inhibits the reaction [E2F5 protein binds to CDC25A promoter]16862215
D009538NicotineNicotine inhibits the reaction [RB1 protein binds to CDC25A promoter]16862215
D009538NicotineNicotine inhibits the reaction [RBL1 protein binds to CDC25A promoter]16862215
D009538NicotineNicotine inhibits the reaction [RBL2 protein binds to CDC25A promoter]16862215
D009538NicotineNicotine promotes the reaction [E2F1 protein binds to CDC25A promoter]16862215
D009538NicotineNicotine promotes the reaction [E2F2 protein binds to CDC25A promoter]16862215
D009538NicotineNicotine promotes the reaction [E2F3 protein binds to CDC25A promoter]16862215
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CDC25A mRNA20971185
C000594117ON123300ON123300 results in increased expression of CDC25A mRNA26873845
C016340o,p'-DDT"o,p'-DDT results in increased expression of CDC25A mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of CDC25A mRNA"24096037
D010100OxygenOxygen deficiency results in decreased expression of CDC25A mRNA26516004
D017239PaclitaxelPaclitaxel results in increased expression of CDC25A mRNA12929121
C500026palbociclibpalbociclib results in decreased expression of CDC25A mRNA22869556
D010269ParaquatParaquat affects the expression of CDC25A mRNA16854511
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CDC25A mRNA26300304
D010634PhenobarbitalPhenobarbital affects the expression of CDC25A mRNA23091169
C121565pifithrinpifithrin inhibits the reaction [sodium arsenite results in decreased expression of CDC25A mRNA]26148435
D010894PiroxicamPiroxicam results in decreased expression of CDC25A mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of CDC25A protein26122529
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of CDC25A mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CDC25A mRNA22079256
D011435Propyl GallatePropyl Gallate affects the expression of CDC25A mRNA18539377
D011441PropylthiouracilPropylthiouracil results in increased expression of CDC25A mRNA18077114
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CDC25A mRNA19167446
C547185riccardin Driccardin D results in decreased expression of CDC25A mRNA24069304
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CDC25A mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of CDC25A mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of CDC25A mRNA23221170
C017947sodium arseniteCAT protein inhibits the reaction [sodium arsenite results in decreased expression of CDC25A mRNA]26148435
C017947sodium arsenitepifithrin inhibits the reaction [sodium arsenite results in decreased expression of CDC25A mRNA]26148435
C017947sodium arsenitesodium arsenite promotes the reaction [ATF3 protein binds to CDC25A promoter]26148435
C017947sodium arsenitesodium arsenite results in decreased expression of CDC25A mRNA17545210|2614843
C017947sodium arsenitesodium arsenite results in decreased expression of CDC25A protein17545210
C017947sodium arsenitesodium arsenite results in increased expression of CDC25A mRNA12016162|2859598
C061133tamibarotenetamibarotene results in decreased expression of CDC25A mRNA15498508
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25A mRNA]24758408
C003377taxifolintaxifolin results in decreased expression of CDC25A mRNA17541156
C505333TEMPOL-HTEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDC25A mRNA]24369695
C505333TEMPOL-HTEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDC25A protein]24369695
C501413tesaglitazartesaglitazar results in increased expression of CDC25A mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDC25A mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDC25A mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDC25A mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC25A mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDC25A mRNA25613284
D013881ThioridazineThioridazine results in increased phosphorylation of CDC25A protein21035837
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CDC25A mRNA28065790
D014118Toxins, Biological"Toxins, Biological affects the expression of CDC25A mRNA"19682533
D014212TretinoinTretinoin affects the expression of CDC25A mRNA15498508
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CDC25A mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDC25A mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CDC25A mRNA19140230
C057693troglitazonetroglitazone results in increased expression of CDC25A mRNA21515302
C004218tylophorinetylophorine analog results in increased expression of CDC25A19284764
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDC25A mRNA]12710931
D014635Valproic AcidValproic Acid results in decreased expression of CDC25A mRNA22580532|2317975
D014635Valproic AcidValproic Acid affects the expression of CDC25A mRNA17292431
D014638VanadatesVanadates results in increased degradation of CDC25A protein12435075
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CDC25A mRNA27169980
D000225AdenineAdenine results in decreased expression of CDC25A mRNA24211769
C009687wortmanninImatinib Mesylate promotes the reaction [wortmannin results in decreased expression of CDC25A protein]17129604
C009687wortmanninwortmannin results in decreased expression of CDC25A protein17129604
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of CDC25A mRNA20370541
D015032ZincZinc deficiency results in increased expression of CDC25A mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004721phosphoprotein phosphatase activity-TAS-  
GO:0004725protein tyrosine phosphatase activity-IBA21873635  
GO:0004725protein tyrosine phosphatase activity-IEA-  
GO:0005515protein binding-IPI7644510  10724175  11298456  14559997  14603323  15161933  
19289404  19615732  25609649  28330616  
GO:0019901protein kinase binding-IPI21376736  
GO:0051087chaperone binding-IPI22843495  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-TAS11139144  
GO:0000082G1/S transition of mitotic cell cycle-TAS-  
GO:0000086G2/M transition of mitotic cell cycle-IBA21873635  
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0008283cell proliferation-TAS11139144  
GO:0009314response to radiation-IDA21376736  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-IBA21873635  
GO:0016579protein deubiquitination-TAS-  
GO:0034644cellular response to UV-IDA19966869  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0045931positive regulation of mitotic cell cycle-IBA21873635  
GO:0051301cell division-IEA-  
GO:0051726regulation of cell cycle-TAS-  
GO:0110032positive regulation of G2/MI transition of meiotic cell cycle-IBA21873635  
GO:1902751positive regulation of cell cycle G2/M phase transition-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-1362277Transcription of E2F targets under negative control by DREAM complexTAS
R-HSA-1538133G0 and Early G1TAS
R-HSA-156711Polo-like kinase mediated eventsTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69242S PhaseTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25ATAS
R-HSA-69610p53-Independent DNA Damage ResponseTAS
R-HSA-69613p53-Independent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsTAS
R-HSA-8863678Neurodegenerative DiseasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal