Gene: CDC25B

994
-
cell division cycle 25B
protein-coding
20p13
Ensembl:ENSG00000101224 MIM:116949 Vega:OTTHUMG00000031764 UniprotKB:P30305
NG_029040.2
PubMed
0   ANCO-SNPs
CD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.943e-2 (AD)  5.765e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMPD40.909
RBM100.908
CCDC220.9
MRPS50.9
WDR50.898
TRMT10.898
NXF10.896
GAK0.891
EDC40.89
DMAP10.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.656
OR4F29-0.616
TRDN-0.291
PHEX-0.265
KLRC2-0.259
KLRB1-0.256
MTRNR2L6-0.25
VNN2-0.244
IL18RAP-0.244
HBD-0.242

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03661Cysteinesulfonic AcidSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25B mRNA"25510870
C4465202-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone"2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone results in decreased expression of CDC25B"16077967
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CDC25B mRNA"19114083
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CDC25B mRNA"19031421
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25B mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CDC25B mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of CDC25B mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of CDC25B mRNA22230336
D000255Adenosine TriphosphateAdenosine Triphosphate inhibits the reaction [Pentachlorophenol results in increased expression of CDC25B mRNA]24642059
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CDC25B protein20106945
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CDC25B mRNA20409345
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDC25B mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of CDC25B protein16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of CDC25B protein10850458
C015001arsenitearsenite results in decreased expression of CDC25B mRNA18929588
C487081belinostatbelinostat results in decreased expression of CDC25B mRNA19606018
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDC25B mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC25B mRNA"20382639
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDC25B mRNA20061341
D004958EstradiolEstradiol results in increased expression of CDC25B protein20208560
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of CDC25B protein]20208560
D004958EstradiolTamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25B protein]20208560
C006780bisphenol Abisphenol A results in increased expression of CDC25B mRNA29027980
C006780bisphenol Abisphenol A results in decreased expression of CDC25B mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CDC25B mRNA17553608
D002066Busulfan[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein20933509
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CDC25B mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of CDC25B mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of CDC25B mRNA26191083
D019256Cadmium ChlorideCadmium Chloride affects the expression of CDC25B mRNA29287790
D019256Cadmium ChlorideCadmium Chloride affects the expression of CDC25B protein29287790
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CDC25B mRNA20061341
D002110CaffeineCaffeine results in increased expression of CDC25B mRNA20864626
D002330CarmustineCarmustine results in decreased expression of CDC25B mRNA16005536
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of CDC25B mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CDC25B mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDC25B mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of CDC25B protein22886373
C012843cinnamic aldehydecinnamic aldehyde analog results in decreased activity of CDC25B protein16343908
C068329clofarabine[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein20933509
D002994ClofibrateClofibrate results in increased expression of CDC25B mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDC25B mRNA19320972|1937684
D016572CyclosporineCyclosporine results in decreased expression of CDC25B mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CDC25B mRNA23640034
D016190CarboplatinCarboplatin results in decreased expression of CDC25B mRNA21296123
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CDC25B mRNA21266533
D002945CisplatinCisplatin results in increased expression of CDC25B mRNA21151649
D002945CisplatinCisplatin results in decreased expression of CDC25B mRNA21296123
C000944dicrotophosdicrotophos results in increased expression of CDC25B mRNA28302478
D004026DieldrinDieldrin results in decreased expression of CDC25B mRNA23041725
D004026DieldrinDieldrin affects the expression of CDC25B mRNA22546817
D004052DiethylnitrosamineAHR protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC25B mRNA]19996281
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDC25B protein15082532
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDC25B mRNA19996281
D004052DiethylnitrosamineFOXM1 protein affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDC25B protein]15082532
D002117CalcitriolCalcitriol results in decreased expression of CDC25B mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CDC25B mRNA21592394
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of CDC25B mRNA21296123
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of CDC25B mRNA19118595
D060754EquolEquol results in decreased expression of CDC25B mRNA16865672
D000431EthanolEthanol results in increased expression of CDC25B protein20621659
C024352fludarabine[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased phosphorylation of CDC25B protein20933509
D005472FluorouracilFluorouracil results in decreased expression of CDC25B mRNA16709241
D005472FluorouracilFluorouracil results in decreased expression of CDC25B mRNA19272435
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDC25B mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of CDC25B mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of CDC25B protein]20208560
D019833GenisteinGenistein results in decreased expression of CDC25B mRNA16865672
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of CDC25B mRNA21782745
D005839GentamicinsGentamicins results in decreased expression of CDC25B mRNA22061828
D005978Glutathione[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate20025242
D017313FenretinideFenretinide results in decreased expression of CDC25B mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CDC25B protein21179406
C016517indole-3-carbinolindole-3-carbinol affects the expression of CDC25B mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CDC25B mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of CDC25B mRNA15956246
C051890irinotecanirinotecan results in decreased expression of CDC25B mRNA15956246
C544151jinfukangjinfukang results in increased expression of CDC25B mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of CDC25B protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDC25B mRNA25961927
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDC25B protein25961927
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CDC25B protein25961927
C541528licochalcone Blicochalcone B results in decreased expression of CDC25B protein24384411
D000069349LinezolidLinezolid results in decreased expression of CDC25B mRNA21296123
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CDC25B mRNA"24972896
D015122MercaptopurineMercaptopurine results in decreased expression of CDC25B mRNA23358152
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDC25B mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of CDC25B mRNA16005536|2413618
C013598methoxyacetic acidmethoxyacetic acid affects the expression of CDC25B mRNA20864626
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of CDC25B mRNA20864626
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of CDC25B mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CDC25B mRNA20061341
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CDC25B mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDC25B mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CDC25B mRNA"26251327
D015735MifepristoneMifepristone results in decreased expression of CDC25B mRNA25972201
C028577monobutyl phthalatemonobutyl phthalate affects the expression of CDC25B mRNA20864626
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of CDC25B mRNA20864626
C020300monomethylarsonic acidmonomethylarsonic acid results in decreased activity of CDC25B protein20025242
D009151Mustard GasMustard Gas results in decreased expression of CDC25B mRNA25102026
D009151Mustard GasMustard Gas results in increased expression of CDC25B mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDC25B mRNA"15585362
D009281NaphthalenesNaphthalenes results in decreased expression of CDC25B protein17337753
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CDC25B mRNA19812364
D009532NickelNickel results in increased expression of CDC25B mRNA19031421|2558310
C022838nickel chloridenickel chloride affects the expression of CDC25B mRNA22546817
C028007nickel monoxidenickel monoxide results in increased expression of CDC25B mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of CDC25B mRNA22714537
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of CDC25B mRNA18636392
D010126OzoneOzone results in increased expression of CDC25B mRNA16330353
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25B mRNA"25510870
D010416PentachlorophenolAdenosine Triphosphate inhibits the reaction [Pentachlorophenol results in increased expression of CDC25B mRNA]24642059
D010416PentachlorophenolPentachlorophenol results in increased expression of CDC25B mRNA24642059
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDC25B protein15082532
D010634PhenobarbitalFOXM1 protein affects the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDC25B protein]15082532
C006253pirinixic acidpirinixic acid results in increased expression of CDC25B mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in decreased expression of CDC25B mRNA19162173
D059808PolyphenolsPolyphenols results in decreased expression of CDC25B mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CDC25B mRNA11678601
D011374ProgesteroneProgesterone results in increased expression of CDC25B mRNA18497975
C010313pseudocumenepseudocumene results in decreased expression of CDC25B protein17337753
C059514resveratrolresveratrol results in decreased expression of CDC25B protein18089832
C547185riccardin Driccardin D results in decreased expression of CDC25B mRNA24069304
C547185riccardin Driccardin D results in decreased expression of CDC25B protein24069304
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of CDC25B mRNA"16678137
D012835Silver NitrateSilver Nitrate analog affects the expression of CDC25B mRNA22831968
D019821SimvastatinSimvastatin affects the expression of CDC25B mRNA19110722
D019821SimvastatinSimvastatin affects the expression of CDC25B protein19110722
C009277sodium arsenate[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate20025242
C009277sodium arsenatesodium arsenate results in decreased activity of CDC25B protein20025242
C017947sodium arsenitesodium arsenite affects the methylation of CDC25B gene28589171
C017947sodium arsenitesodium arsenite results in decreased activity of CDC25B protein20025242
C017947sodium arsenitesodium arsenite results in decreased expression of CDC25B mRNA12377979|2271453
C016104sodium bichromatesodium bichromate results in increased expression of CDC25B mRNA12325037
D012969Sodium FluorideSodium Fluoride results in increased expression of CDC25B mRNA27862939
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CDC25B mRNA"26680231
D013629TamoxifenTamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25B protein]20208560
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CDC25B mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CDC25B mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDC25B mRNA17101203|1968428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDC25B mRNA19684285
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDC25B mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDC25B mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of CDC25B mRNA19031421
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CDC25B mRNA19031421
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CDC25B mRNA25613284
D013866ThioguanineThioguanine results in decreased expression of CDC25B mRNA16005536
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CDC25B mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CDC25B mRNA15289447
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of CDC25B mRNA"17951470
D014241TrichloroethyleneTrichloroethylene affects the expression of CDC25B mRNA21135412
C012589trichostatin Atrichostatin A results in decreased expression of CDC25B mRNA15901671
C012589trichostatin Atrichostatin A results in decreased expression of CDC25B mRNA19606018
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CDC25B mRNA19042947
C001899triptolidetriptolide results in increased expression of CDC25B mRNA23639586
C022884undecaneundecane results in decreased expression of CDC25B protein17337753
D014520UrethaneUrethane results in increased expression of CDC25B mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of CDC25B mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of CDC25B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CDC25B mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of CDC25B mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CDC25B gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of CDC25B mRNA26682919
D014810Vitamin EVitamin E results in increased expression of CDC25B mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004721phosphoprotein phosphatase activity-TAS-  
GO:0004725protein tyrosine phosphatase activity-IBA21873635  
GO:0004725protein tyrosine phosphatase activity-TAS9188863  
GO:0005515protein binding-IPI7644510  10713667  12764136  12766774  12871587  15173315  
15629715  16672277  26496610  
GO:0019901protein kinase binding-IPI12400006  15908796  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-IBA21873635  
GO:0000086G2/M transition of mitotic cell cycle-TAS12400006  
GO:0000278mitotic cell cycle-TAS9188863  
GO:0001556oocyte maturation-IEA-  
GO:0006468protein phosphorylation-IDA17332740  
GO:0007144female meiosis I-IEA-  
GO:0008284positive regulation of cell proliferation-TAS8276402  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-IBA21873635  
GO:0032467positive regulation of cytokinesis-IMP17332740  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0045860positive regulation of protein kinase activity-IEA-  
GO:0045931positive regulation of mitotic cell cycle-IBA21873635  
GO:0045931positive regulation of mitotic cell cycle-IMP17332740  
GO:0051301cell division-IEA-  
GO:0110032positive regulation of G2/MI transition of meiotic cell cycle-IBA21873635  
GO:1902751positive regulation of cell cycle G2/M phase transition-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IDA15908796  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005813centrosome-IDA15908796  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-69242S PhaseTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsTAS
R-HSA-8863678Neurodegenerative DiseasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23897225Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis. (2013 Nov)Assassi SArthritis Rheum