Gene: DLEC1

9940
CFAP81|DLC-1|DLC1|F56
DLEC1, cilia and flagella associated protein
protein-coding
3p22.2
Ensembl:ENSG00000008226 MIM:604050 Vega:OTTHUMG00000131085 UniprotKB:Q9Y238
NG_023237.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.860e-2 (AD)  7.902e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C10orf1050.708
TMCO40.672
GMPR0.67
STK330.647
MUC10.646
LPIN30.635
CYP21A20.632
RHOD0.632
SYTL40.625
MMEL10.623

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADRA2A-0.417
CPLX3-0.389
MCHR1-0.382
HRK-0.381
NEUROD6-0.379
PPEF1-0.378
PNOC-0.37
DUSP27-0.369
VGF-0.363
ZNF385D-0.361

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DLEC1 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of DLEC1 mRNA25181051
D003471CuprizoneCuprizone results in increased expression of DLEC1 mRNA26577399
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of DLEC1 mRNA28962523
D004041Dietary FatsDietary Fats results in increased expression of DLEC1 mRNA25016146
D007213IndomethacinIndomethacin results in increased expression of DLEC1 mRNA28201806
C017947sodium arsenitesodium arsenite affects the methylation of DLEC1 gene28589171

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008285negative regulation of cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA10213508  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28674222Small suitability of the DLEC1, MLH1 and TUSC4 mRNA expression analysis as potential prognostic or differentiating markers for NSCLC patients in the Polish population. (2017 Jun)Kordiak JJ Genet
22966295Methylation of the DLEC1 gene correlates with poor prognosis in Japanese lung cancer patients. (2010 Mar)Sasaki HOncol Lett