Gene: XYLB

9942
-
xylulokinase
protein-coding
3p22.2
Ensembl:ENSG00000093217 MIM:604049 Vega:OTTHUMG00000131294 UniprotKB:O75191
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.866e-2 (AD)  1.376e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STXBP50.833
KCNH10.829
ZNF7740.828
TUBGCP40.819
MTUS20.816
NCR3LG10.813
TCP11L10.809
RGP10.802
ZNF1320.8
INCENP0.8

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.466
RAB13-0.447
FXYD3-0.418
HEY2-0.413
COPZ2-0.408
STON2-0.404
PPBP-0.399
S100A1-0.398
TMEM176A-0.397
HEBP2-0.391

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of XYLB mRNA"21724226
D000082AcetaminophenAcetaminophen results in decreased expression of XYLB mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of XYLB mRNA17562736
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of XYLB protein26597043
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of XYLB mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of XYLB mRNA19770486
C006780bisphenol Abisphenol A results in increased methylation of XYLB promoter27312807
C006780bisphenol Abisphenol A results in increased expression of XYLB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of XYLB gene28505145
D002065BuspironeBuspirone results in increased expression of XYLB mRNA24136188
C584509C646 compoundC646 compound results in decreased expression of XYLB mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of XYLB mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of XYLB mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of XYLB mRNA27989131
C000944dicrotophosdicrotophos results in increased expression of XYLB mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of XYLB mRNA19638242
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XYLB mRNA22079256
C069837fullerene C60fullerene C60 affects the expression of XYLB mRNA19167457
D005897GlafenineGlafenine results in decreased expression of XYLB mRNA24136188
D017313FenretinideFenretinide results in increased expression of XYLB mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of XYLB mRNA17183730
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of XYLB protein18951874
C544151jinfukangjinfukang results in increased expression of XYLB mRNA27392435
C410337K 7174K 7174 results in decreased expression of XYLB mRNA24086573
C028007nickel monoxidenickel monoxide results in increased expression of XYLB mRNA19167457
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of XYLB mRNA23427857
C006253pirinixic acidpirinixic acid results in increased expression of XYLB mRNA17426115
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XYLB mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of XYLB mRNA22079256
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of XYLB mRNA25895662
D053260SootSoot results in increased expression of XYLB mRNA26551751
D013501Surface-Active AgentsSurface-Active Agents results in decreased expression of XYLB mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of XYLB mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XYLB mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of XYLB mRNA21215274
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of XYLB protein18951874
C009495titanium dioxidetitanium dioxide results in increased expression of XYLB mRNA23557971
D014520UrethaneUrethane results in decreased expression of XYLB mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of XYLB mRNA17183730
D014635Valproic AcidValproic Acid results in decreased methylation of XYLB gene29154799
D014640VancomycinVancomycin results in increased expression of XYLB mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004856xylulokinase activity-EXP23179721  
GO:0004856xylulokinase activity-IBA21873635  
GO:0004856xylulokinase activity-IDA23179721  
GO:0005524ATP binding-IEA-  
GO:0016773phosphotransferase activity, alcohol group as acceptor-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-TAS9763671  
GO:0005997xylulose metabolic process-IBA21873635  
GO:0005997xylulose metabolic process-IDA23179721  
GO:0005998xylulose catabolic process-TAS9763671  
GO:0006091generation of precursor metabolites and energy-TAS9763671  
GO:0016310phosphorylation-IBA21873635  
GO:0019640glucuronate catabolic process to xylulose 5-phosphate-TAS-  
GO:0042732D-xylose metabolic process-IEA-  
GO:0046835carbohydrate phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00040Pentose and glucuronate interconversions
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-5661270Catabolism of glucuronate to xylulose-5-phosphateTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27164557Genetic Relationship between Schizophrenia and Nicotine Dependence. (2016 May 10)Chen JSci Rep