Gene: GFPT2

9945
GFAT|GFAT 2|GFAT2
glutamine-fructose-6-phosphate transaminase 2
protein-coding
5q35.3
Ensembl:ENSG00000131459 MIM:603865 Vega:OTTHUMG00000163442 UniprotKB:O94808
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.282e-1 (AD)  4.481e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NOP20.831
FADS30.823
GTF2IRD10.818
ZDHHC180.811
POR0.806
SURF40.802
MARK30.799
TMEM430.797
TXLNA0.796
CRTC20.792

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.529
OR4F29-0.473
PDE11A-0.247
KLRC2-0.239
OR6C74-0.233
CETP-0.226
RERGL-0.226
CHP2-0.212
CARD17-0.21
RNASE8-0.205

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00130L-GlutamineSmall Molecule56-85-9Approved|Investigational|NutraceuticalEnzyme
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFPT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFPT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFPT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFPT2 mRNA"27188386
D020106AcrylamideAcrylamide affects the expression of GFPT2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GFPT2 mRNA22100608
D000393Air PollutantsAir Pollutants analog results in increased expression of GFPT2 mRNA21757418
D000393Air PollutantsAir Pollutants results in increased expression of GFPT2 mRNA21757418
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GFPT2 mRNA24449571
D001151ArsenicArsenic affects the methylation of GFPT2 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of GFPT2 mRNA"24160326
D001280AtrazineAtrazine results in increased expression of GFPT2 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of GFPT2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GFPT2 mRNA20064835
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GFPT2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of GFPT2 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of GFPT2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GFPT2 mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of GFPT2 mRNA20147733
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of GFPT2 mRNA19925653
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GFPT2 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of GFPT2 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of GFPT2 mRNA25979313
D019327Copper SulfateCopper Sulfate affects the expression of GFPT2 mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GFPT2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GFPT2 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of GFPT2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of GFPT2 mRNA19561079
D004041Dietary FatsDietary Fats results in decreased expression of GFPT2 mRNA18042831
D002117CalcitriolCalcitriol results in decreased expression of GFPT2 mRNA26485663
D004237DiuronDiuron results in decreased expression of GFPT2 mRNA21551480|2515243
C118739entinostatentinostat results in increased expression of GFPT2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFPT2 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GFPT2 mRNA22079256
D000431EthanolEthanol results in decreased expression of GFPT2 mRNA29018328
C039281furanfuran results in decreased expression of GFPT2 mRNA25539665
D017313FenretinideFenretinide results in increased expression of GFPT2 mRNA28973697
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of GFPT2 mRNA"26377693
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GFPT2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GFPT2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of GFPT2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of GFPT2 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of GFPT2 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of GFPT2 mRNA27392435
D007649KetamineKetamine results in decreased expression of GFPT2 mRNA20080153
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GFPT2 mRNA24810058
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of GFPT2 mRNA23876855
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GFPT2 mRNA"25102311
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of GFPT2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GFPT2 mRNA"25554681
D009532NickelNickel results in increased expression of GFPT2 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of GFPT2 mRNA22714537
D000073878Palm OilPalm Oil results in decreased expression of GFPT2 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of GFPT2 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GFPT2 mRNA23978341
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GFPT2 mRNA"27188386
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GFPT2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GFPT2 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in increased expression of GFPT2 mRNA18037150
C059514resveratrolresveratrol results in increased expression of GFPT2 mRNA25866375
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of GFPT2 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of GFPT2 mRNA23806026|2589566
C017947sodium arsenitesodium arsenite affects the methylation of GFPT2 gene28589171
D053260SootSoot results in increased expression of GFPT2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GFPT2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GFPT2 mRNA27562557
D014212TretinoinTretinoin results in decreased expression of GFPT2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of GFPT2 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of GFPT2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GFPT2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of GFPT2 mRNA19140230
D014520UrethaneUrethane results in increased expression of GFPT2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GFPT2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GFPT2 mRNA19101580|2800136
D014635Valproic AcidValproic Acid results in increased methylation of GFPT2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GFPT2 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of GFPT2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004360glutamine-fructose-6-phosphate transaminase (isomerizing) activity-IBA21873635  
GO:0004360glutamine-fructose-6-phosphate transaminase (isomerizing) activity-TAS-  
GO:0005515protein binding-IPI21044950  
GO:0097367carbohydrate derivative binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006002fructose 6-phosphate metabolic process-IBA21873635  
GO:0006002fructose 6-phosphate metabolic process-TAS10198162  
GO:0006047UDP-N-acetylglucosamine metabolic process-IBA21873635  
GO:0006048UDP-N-acetylglucosamine biosynthetic process-IEA-  
GO:0006048UDP-N-acetylglucosamine biosynthetic process-TAS-  
GO:0006112energy reserve metabolic process-TAS10198162  
GO:0006541glutamine metabolic process-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446210Synthesis of UDP-N-acetyl-glucosamineTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28814982Cord blood DNA methylation and adiposity measures in early and mid-childhood. (2017)Kresovich JKClin Epigenetics