Gene: WDR1

9948
AIP1|HEL-S-52|NORI-1
WD repeat domain 1
protein-coding
4p16.1
Ensembl:ENSG00000071127 MIM:604734 Vega:OTTHUMG00000160253 UniprotKB:O75083
NG_027876.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.953e-1 (AD)  1.548e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEC61A10.898
ARFGAP30.895
RPN20.883
EIF4A10.882
STAT30.873
TM9SF10.869
TINF20.861
KDELR20.859
KDELR10.855
SSR30.853

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.653
OR4F29-0.621
RERGL-0.158
RNASE8-0.154
HMHB1-0.14
LYPD8-0.135
C14orf180-0.134
HES5-0.134
OR6C74-0.132
TCL1A-0.13

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased expression of WDR1 mRNA"23826121
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of WDR1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WDR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WDR1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of WDR1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of WDR1 mRNA27153756
D000616AminoglutethimideAminoglutethimide results in increased expression of WDR1 protein26102013
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WDR1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of WDR1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WDR1 mRNA"19150397|2001819
C044887beta-methylcholinebeta-methylcholine affects the expression of WDR1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of WDR1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of WDR1 mRNA15336504
D002104CadmiumCadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of WDR1 protein]29107029
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of WDR1 mRNA27339419
C100187chloropicrinchloropicrin results in increased expression of WDR1 mRNA26352163
C018021cobaltous chloridecobaltous chloride results in decreased expression of WDR1 mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of WDR1 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of WDR1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of WDR1 mRNA21266533
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of WDR1 mRNA19638242
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of WDR1 protein"22248470
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of WDR1 protein"22248470
D004237DiuronDiuron results in increased expression of WDR1 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of WDR1 mRNA20227414
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of WDR1 mRNA14976129|1755557
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WDR1 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of WDR1 mRNA24793618
D005557FormaldehydeFormaldehyde results in increased expression of WDR1 mRNA20655997|2364984
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of WDR1 protein]23178681
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of WDR1 protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of WDR1 protein23178681
C492448ICG 001ICG 001 results in increased expression of WDR1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of WDR1 mRNA25613284
D007529Isoflavones"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of WDR1 protein"22248470
D008095Lithocholic AcidLithocholic Acid results in decreased expression of WDR1 protein21224350
D008727MethotrexateMethotrexate affects the expression of WDR1 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride affects the expression of WDR1 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of WDR1 mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of WDR1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of WDR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of WDR1 mRNA"25554681
C031721naphthalenenaphthalene results in decreased expression of WDR1 protein19438287
D009532NickelNickel results in increased expression of WDR1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of WDR1 mRNA19167457
C025256nonylphenolnonylphenol results in increased expression of WDR1 protein19260726
C507134ON 01910ON 01910 results in increased expression of WDR1 mRNA22351695
D010578PetroleumPetroleum affects the expression of WDR1 mRNA25208076
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of WDR1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of WDR1 mRNA25270620
D010634PhenobarbitalPhenobarbital results in increased expression of WDR1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WDR1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of WDR1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of WDR1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of WDR1 mRNA25270620
C037219quinolinequinoline analog results in increased expression of WDR1 protein18645022
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of WDR1 mRNA14699072
D012643SeleniumSelenium results in increased expression of WDR1 mRNA19244175
D013629TamoxifenTamoxifen affects the expression of WDR1 mRNA14699072
D013629TamoxifenTamoxifen affects the expression of WDR1 mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of WDR1 mRNA18976794
D013749TetrachlorodibenzodioxinCadmium affects the reaction [Tetrachlorodibenzodioxin affects the expression of WDR1 protein]29107029
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WDR1 protein29107029
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of WDR1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WDR1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of WDR1 mRNA25613284
D014050TolueneToluene results in decreased expression of WDR1 mRNA28245982
D014635Valproic AcidValproic Acid affects the expression of WDR1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of WDR1 mRNA23179753
D014810Vitamin EVitamin E results in increased expression of WDR1 mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of WDR1 mRNA"25208076
C088658zoledronic acidzoledronic acid results in increased expression of WDR1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0051015actin filament binding-IBA21873635  
GO:0051015actin filament binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002446neutrophil mediated immunity-IEA-  
GO:0002576platelet degranulation-TAS-  
GO:0007605sensory perception of sound-TAS10036186  
GO:0008360regulation of cell shape-IEA-  
GO:0030042actin filament depolymerization-IBA21873635  
GO:0030043actin filament fragmentation-IEA-  
GO:0030220platelet formation-IEA-  
GO:0030834regulation of actin filament depolymerization-IDA15629458  
GO:0030836positive regulation of actin filament depolymerization-IBA21873635  
GO:0030865cortical cytoskeleton organization-IEA-  
GO:0040011locomotion-IBA21873635  
GO:0042247establishment of planar polarity of follicular epithelium-IEA-  
GO:0043297apical junction assembly-IDA25792565  
GO:0045199maintenance of epithelial cell apical/basal polarity-IDA25792565  
GO:0045214sarcomere organization-IBA21873635  
GO:0048713regulation of oligodendrocyte differentiation-IEA-  
GO:0060307regulation of ventricular cardiac muscle cell membrane repolarization-IEA-  
GO:1990266neutrophil migration-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002102podosome-IEA-  
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005911cell-cell junction-IDA25792565  
GO:0030054cell junction-IDA-  
GO:0030864cortical actin cytoskeleton-IBA21873635  
GO:0042643actomyosin, actin portion-IBA21873635  
GO:0042995cell projection-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21736419Platelet proteome in healthy volunteers who smoke. (2012)Della Corte APlatelets