Gene: AMMECR1

9949
AMMERC1|MFHIEN
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
protein-coding
Xq23
Ensembl:ENSG00000101935 MIM:300195 Vega:OTTHUMG00000022197 UniprotKB:Q9Y4X0
NG_016469.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs5942915chrX:110305798 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17254838chrX:110228132 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RC3H10.815
ZMYM60.813
ATP6V0A20.807
MED230.805
RLF0.8
ATXN70.799
LRIG20.794
CCNT20.791
NR2C10.788
SETDB20.787

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.373
OR4F29-0.336
KLRC2-0.294
LYPD1-0.262
PLA2G5-0.254
APOA1-0.244
NKX6-1-0.241
BCL7C-0.233
AQP5-0.228
PINLYP-0.227

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of AMMECR1 mRNA"19167446
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of AMMECR1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of AMMECR1 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AMMECR1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AMMECR1 mRNA19770486
D001151ArsenicArsenic affects the methylation of AMMECR1 gene25304211
C015001arsenitearsenite affects the expression of AMMECR1 mRNA22959463
D001280AtrazineAtrazine results in decreased expression of AMMECR1 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of AMMECR1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AMMECR1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AMMECR1 mRNA23735875
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AMMECR1 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of AMMECR1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of AMMECR1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AMMECR1 mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of AMMECR1 mRNA24763279
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of AMMECR1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of AMMECR1 mRNA19376846
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of AMMECR1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of AMMECR1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of AMMECR1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of AMMECR1 mRNA22147139
D016572CyclosporineCyclosporine results in increased expression of AMMECR1 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of AMMECR1 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AMMECR1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of AMMECR1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of AMMECR1 mRNA25016146
D004221DisulfiramDisulfiram results in decreased expression of AMMECR1 mRNA20530235
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AMMECR1 mRNA22079256
D005557FormaldehydeFormaldehyde results in decreased expression of AMMECR1 mRNA23649840
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of AMMECR1 mRNA24763279
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AMMECR1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of AMMECR1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AMMECR1 mRNA23430699
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of AMMECR1 mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of AMMECR1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AMMECR1 mRNA"25554681
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of AMMECR1 mRNA19074003
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AMMECR1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AMMECR1 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of AMMECR1 mRNA21795739
D011794QuercetinQuercetin results in decreased expression of AMMECR1 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of AMMECR1 mRNA19167446
C010327salinomycinsalinomycin results in decreased expression of AMMECR1 mRNA19682730
D012969Sodium FluorideSodium Fluoride results in decreased expression of AMMECR1 mRNA27862939
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of AMMECR1 mRNA"26680231
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of AMMECR1 mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in decreased expression of AMMECR1 mRNA19074003
D013893ThiramThiram results in decreased expression of AMMECR1 mRNA20530235
C483909torcetrapibtorcetrapib results in increased expression of AMMECR1 mRNA23228038
D014635Valproic AcidValproic Acid affects the expression of AMMECR1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AMMECR1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of AMMECR1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of AMMECR1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of AMMECR1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21304492  25416956  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA27811305  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal