Gene: CDC25C

995
CDC25|PPP1R60
cell division cycle 25C
protein-coding
5q31.2
Ensembl:ENSG00000158402 MIM:157680 Vega:OTTHUMG00000129203 UniprotKB:P30307
NC_000005.10
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.522e-2 (AD)  8.307e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGEB10.492
HBE10.459
MAGEB20.456
CDK10.43
ACSM30.429
RHAG0.428
CTCFL0.421
PRAME0.418
PAGE50.413
MAGEA30.407

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITIH1-0.24
HIST1H3C-0.231
ETV2-0.227
TACR3-0.223
C16orf82-0.217
SMIM1-0.213
ANXA13-0.213
ADA-0.211
MUSK-0.21
SH2D1A-0.208

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CDC25C mRNA"28903501
C495172(19Z)-halichondramide(19Z)-halichondramide results in decreased expression of CDC25C protein23147639
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25C mRNA"25510870
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein]22230261
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]22230261
C4465202-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone"2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone results in decreased expression of CDC25C"16077967
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDC25C mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25C mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25C mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25C mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25C mRNA"25510870
C450643(2)-5,6,7,8,4'-pentamethoxyflavanone"(2)-5,6,7,8,4'-pentamethoxyflavanone results in decreased expression of CDC25C protein"19450678
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CDC25C mRNA"16120219
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of CDC25C mRNA25088246
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CDC25C mRNA"20816883
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of CDC25C protein20469912
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of CDC25C protein20469912
C0702792'-cyano-2'-deoxyarabinofuranosylcytosine2'-cyano-2'-deoxyarabinofuranosylcytosine results in increased phosphorylation of and results in decreased activity of CDC25C protein16061671
C0228302-methoxyestradiol2-methoxyestradiol results in decreased expression of and affects the phosphorylation of CDC25C protein23967052
C5467063-(3,4,5-trimethoxybenzylidene)-5-carboethoxyindolin-2-one"3-(3,4,5-trimethoxybenzylidene)-5-carboethoxyindolin-2-one results in increased expression of CDC25C protein modified form"19883635
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in decreased expression of CDC25C"22290291
C0005885823-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-amine"3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-2-amine results in decreased expression of CDC25C protein"24471873
C5277933-methyl-9-(2-oxa-2lambda(5)-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro(5.5)undecane"3-methyl-9-(2-oxa-2lambda(5)-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro(5.5)undecane results in decreased expression of CDC25C protein"18176113
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDC25C mRNA"27188386
C5688624-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline"4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased expression of CDC25C protein"24161432
C4943564-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione"4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione results in decreased expression of CDC25C mRNA"17440966
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of CDC25C mRNA19191707
C4948984-oxofenretinide4-oxofenretinide results in decreased expression of CDC25C protein16540676
C5036435-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin"5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin affects the expression of CDC25C protein"16179969
C5036435-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin"MAPK8 protein promotes the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin affects the expression of CDC25C protein]"16179969
C5036435-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin"pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin affects the expression of CDC25C protein]"16179969
C5031195-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone affects the expression of CDC25C protein16179969
C5497535,7,3'-trihydroxy-3,4'-dimethoxyflavone"5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDC25C protein"21229608
C5715326-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid results in decreased phosphorylation of CDC25C protein25316768
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDC25C mRNA"27188386
C5319376-O-angeloylenolin6-O-angeloylenolin results in decreased expression of CDC25C protein21192922
C5319376-O-angeloylenolin6-O-angeloylenolin results in decreased expression of CDC25C protein modified form21192922
C0548527-hydroxystaurosporine7-hydroxystaurosporine inhibits the reaction [erythritol anhydride results in increased expression of CDC25C protein modified form]25633853
D000082AcetaminophenAcetaminophen results in decreased expression of CDC25C mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CDC25C mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CDC25C mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [erythritol anhydride results in increased expression of CDC25C protein modified form]25633853
D020106AcrylamideAcrylamide results in increased expression of CDC25C mRNA28959563
C412373AG 1879AG 1879 results in decreased expression of CDC25C mRNA25051199
D000393Air PollutantsAir Pollutants analog results in decreased expression of CDC25C mRNA21757418
C038491allyl sulfideallyl sulfide results in decreased expression of CDC25C protein24650757
C038491allyl sulfideCHEK1 protein promotes the reaction [allyl sulfide results in decreased expression of CDC25C protein]24650757
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of CDC25C mRNA]25051199
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDC25C protein]22266097
D000872AnthocyaninsAnthocyanins results in decreased expression of and results in increased phosphorylation of CDC25C protein27444805
D000872AnthocyaninsAnthocyanins results in increased phosphorylation of CDC25C protein27444805
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CDC25C mRNA24449571
D047310ApigeninApigenin results in decreased expression of CDC25C protein26961604
D001115Arecoline[[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein22108589
D001115ArecolineArecoline results in decreased expression of CDC25C protein22108589
D001151ArsenicArsenic affects the methylation of CDC25C gene25304211
C006632arsenic trioxide[arsenic trioxide co-treated with Paclitaxel] results in increased expression of CDC25C protein modified form19781537
C006632arsenic trioxidearsenic trioxide results in decreased expression of CDC25C protein10850458
C006632arsenic trioxidearsenic trioxide affects the expression of and affects the phosphorylation of CDC25C protein23337567
C015001arsenitearsenite results in decreased expression of CDC25C mRNA18929588
D001379AzathioprineAzathioprine results in decreased expression of CDC25C mRNA22623647
C040929bafilomycin A1bafilomycin A1 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]29074359
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDC25C mRNA16120219|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDC25C mRNA20504355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDC25C mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDC25C mRNA"20018196|2038263
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDC25C mRNA20061341
D004958EstradiolEstradiol results in increased expression of CDC25C mRNA19167446
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of CDC25C mRNA]25210133
D004958EstradiolEstradiol results in increased expression of CDC25C mRNA25210133
D017438Bisphenol A-Glycidyl MethacrylateBisphenol A-Glycidyl Methacrylate results in decreased expression of CDC25C mRNA20673999
D017438Bisphenol A-Glycidyl MethacrylateBisphenol A-Glycidyl Methacrylate results in decreased expression of CDC25C protein20673999
D017438Bisphenol A-Glycidyl MethacrylateCAT protein inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in decreased expression of CDC25C mRNA]20673999
C006780bisphenol Abisphenol A results in decreased expression of CDC25C mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of CDC25C mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of CDC25C mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CDC25C mRNA12419474
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of CDC25C mRNA14729362|1500399
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CDC25C mRNA20061341
D002110CaffeineCaffeine inhibits the reaction [CDC25C protein binds to YWHAQ protein]11835680
D002110CaffeineCaffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDC25C protein]15975956
D002110CaffeineCaffeine results in decreased expression of CDC25C protein11835680
C553149camphorquinonecamphorquinone results in decreased expression of CDC25C mRNA26658076
C553149camphorquinonecamphorquinone results in decreased expression of CDC25C protein26658076
D002220CarbamazepineCarbamazepine affects the expression of CDC25C mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDC25C mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CDC25C mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CDC25C mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDC25C mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of CDC25C mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDC25C mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CDC25C mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CDC25C mRNA19167446
C024015cryptolepinecryptolepine results in decreased expression of CDC25C mRNA16120219
C038106cucurbitacin Icucurbitacin I results in decreased expression of CDC25C protein24858077
D003474CurcuminCurcumin results in increased phosphorylation of CDC25C protein19401701
D016572CyclosporineCyclosporine results in decreased expression of CDC25C mRNA21632981|2556210
D000069439DasatinibDasatinib results in decreased expression of CDC25C mRNA20579391
C014347decitabinedecitabine results in decreased expression of CDC25C mRNA19363521
C014347decitabineTP53 protein affects the reaction [decitabine results in decreased expression of CDC25C mRNA]19363521
D013759DronabinolDronabinol results in decreased expression of CDC25C protein16818634
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of and results in increased phosphorylation of CDC25C protein20143254
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CDC25C protein23754639
C042577diallyl trisulfidediallyl trisulfide results in increased phosphorylation of and results in increased degradation of CDC25C protein16707465
C042577diallyl trisulfideEUK-134 inhibits the reaction [diallyl trisulfide results in increased phosphorylation of and results in increased degradation of CDC25C protein]16707465
D003976DiazinonDiazinon affects the expression of CDC25C mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDC25C mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CDC25C mRNA28962523
D002945CisplatinCisplatin results in increased expression of and results in increased phosphorylation of CDC25C protein20623183
D002945CisplatinESR2 protein inhibits the reaction [Cisplatin results in increased expression of and results in increased phosphorylation of CDC25C protein]20623183
D002945CisplatinCisplatin results in increased expression of CDC25C mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of CDC25C mRNA28302478
D004026DieldrinDieldrin affects the expression of CDC25C mRNA22546817
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDC25C protein15082532
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDC25C mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDC25C mRNA]17854601
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CDC25C mRNA15591538
D002117CalcitriolCalcitriol results in decreased expression of CDC25C mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CDC25C mRNA21592394
C541783dimethyl alpha-ketoglutaratedimethyl alpha-ketoglutarate inhibits the reaction [tributyltin results in decreased expression of CDC25C protein]26961604
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of CDC25C mRNA22302311
D004317DoxorubicinCDC25C protein inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]19074854
D004317DoxorubicinCDC25C protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]19074854
D004317DoxorubicinCDC25C protein inhibits the reaction [Doxorubicin results in increased phosphorylation of CDK1 protein]19074854
D004317DoxorubicinCDC25C protein results in increased susceptibility to Doxorubicin19074854
D004317DoxorubicinDoxorubicin results in increased phosphorylation of and results in decreased activity of CDC25C protein17320279
C034192ellipticineellipticine results in decreased expression of CDC25C protein16027529
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CDC25C mRNA22079256
D060754EquolEquol results in decreased expression of CDC25C mRNA16865672
C007366erythritol anhydride7-hydroxystaurosporine inhibits the reaction [erythritol anhydride results in increased expression of CDC25C protein modified form]25633853
C007366erythritol anhydrideAcetylcysteine inhibits the reaction [erythritol anhydride results in increased expression of CDC25C protein modified form]25633853
C007366erythritol anhydrideCHEK1 protein promotes the reaction [erythritol anhydride results in increased expression of CDC25C protein modified form]25633853
C007366erythritol anhydrideerythritol anhydride results in increased expression of CDC25C protein modified form25633853
C007366erythritol anhydrideerythritol anhydride results in increased phosphorylation of CDC25C protein25633853
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC25C mRNA17942748
D005047EtoposideEtoposide results in decreased expression of CDC25C mRNA16120219
C433928EUK-134EUK-134 inhibits the reaction [diallyl trisulfide results in increased phosphorylation of and results in increased degradation of CDC25C protein]16707465
C017875fisetinfisetin results in decreased expression of CDC25C protein28181380
D005472FluorouracilCDC25C protein affects the susceptibility to Fluorouracil15548681
D005472FluorouracilFluorouracil results in decreased expression of CDC25C mRNA19272435
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDC25C mRNA20938992
C058728fosbretabulinfosbretabulin analog results in decreased expression of CDC25C protein25529822
C039281furanfuran results in increased expression of CDC25C mRNA25539665
C056507gemcitabine[gemcitabine co-treated with ON 01910] results in decreased expression of CDC25C protein20103597
D019833GenisteinGenistein results in decreased expression of CDC25C mRNA16865672
D005978Glutathione[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate20025242
C081021Go 6976Go 6976 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]29074359
D006247HarmineHarmine results in increased expression of CDC25C mRNA25751815
C001330hellebrigeninhellebrigenin results in decreased phosphorylation of CDC25C protein24954031
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde affects the expression of CDC25C mRNA22302311
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CDC25C mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CDC25C mRNA12419474
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CDC25C mRNA14729362
C492448ICG 001ICG 001 results in decreased expression of CDC25C mRNA26191083
C544151jinfukangjinfukang results in increased expression of CDC25C mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CDC25C mRNA27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDC25C mRNA25961927
D007840LatexLatex analog results in increased expression of CDC25C mRNA24768652
C045463leflunomideleflunomide results in decreased expression of CDC25C mRNA28988120
C038753leptomycin Bleptomycin B results in decreased expression of CDC25C mRNA20803015
C032854leupeptinleupeptin inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]29074359
C032854leupeptinleupeptin results in increased expression of CDC25C protein29074359
D018021Lithium ChlorideLithium Chloride results in decreased expression of CDC25C mRNA17440966
D018021Lithium ChlorideLithium Chloride results in decreased expression of CDC25C protein17440966
D018021Lithium ChlorideLithium Chloride results in increased expression of CDC25C mRNA22493441
C000589248LL-202LL-202 results in decreased expression of CDC25C protein24752227
D008154LucanthoneLucanthone results in decreased expression of CDC25C mRNA21148553
C013099mancozebmancozeb results in increased phosphorylation of CDC25C protein21375462
C054474manumycinmanumycin inhibits the reaction [Plant Extracts results in decreased expression of CDC25C mRNA]25051199
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDC25C mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of CDC25C mRNA21678067
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CDC25C mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CDC25C mRNA20061341
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CDC25C mRNA23649840
C008493methylselenic acidmethylselenic acid results in decreased expression of CDC25C mRNA11830524
D015735MifepristoneMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDC25C protein]22266097
C008548morinmorin results in decreased expression of CDC25C mRNA28689916
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of CDC25C mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA16357179
D009151Mustard GasMustard Gas results in decreased expression of CDC25C mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CDC25C mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CDC25C mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CDC25C mRNA19812364
C022838nickel chloridenickel chloride affects the expression of CDC25C mRNA22546817
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in decreased expression of CDC25C mRNA22561872
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of CDC25C mRNA22561872
C069741norcantharidinnorcantharidin results in decreased expression of CDC25C protein21266192
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of CDC25C mRNA19074003
C025589ochratoxin A2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein]22230261
C025589ochratoxin A2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]22230261
C025589ochratoxin AMAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein]22230261
C025589ochratoxin AMAPK14 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]22230261
C025589ochratoxin AMAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein]22230261
C025589ochratoxin AMAPK1 protein promotes the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]22230261
C025589ochratoxin Aochratoxin A results in decreased expression of CDC25C mRNA20060447
C025589ochratoxin Aochratoxin A results in decreased expression of CDC25C protein20060447|2223026
C025589ochratoxin Aochratoxin A results in decreased expression of CDC25C protein modified form22230261
C025589ochratoxin ASB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein]22230261
C025589ochratoxin ASB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]22230261
C507134ON 01910[gemcitabine co-treated with ON 01910] results in decreased expression of CDC25C protein20103597
C507134ON 01910ON 01910 results in decreased expression of CDC25C protein20103597|2447187
C507134ON 01910ON 01910 results in decreased phosphorylation of CDC25C protein19029951|2531676
C507134ON 01910ON 01910 results in increased phosphorylation of CDC25C protein19029951
D017239Paclitaxel[arsenic trioxide co-treated with Paclitaxel] results in increased expression of CDC25C protein modified form19781537
D017239PaclitaxelPaclitaxel results in decreased expression of CDC25C mRNA18058816
D017239Paclitaxel[pifithrin co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein18516295
C500026palbociclibpalbociclib results in decreased expression of CDC25C mRNA22869556
C482884panduratin Apanduratin A results in decreased expression of CDC25C protein16497706
D052638Particulate MatterParticulate Matter results in decreased expression of CDC25C mRNA28366736
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDC25C mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of CDC25C mRNA19095052
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of CDC25C protein26678675
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDC25C protein15082532
D009764o-Phthalaldehydeo-Phthalaldehyde affects the expression of CDC25C mRNA22302311
C121565pifithrin[pifithrin co-treated with Paclitaxel] results in increased phosphorylation of CDC25C protein18516295
C008922piperinepiperine inhibits the reaction [IL2 protein results in increased expression of CDC25C protein]25655587
C027260pirarubicinpirarubicin results in increased phosphorylation of CDC25C protein22580740
C006253pirinixic acidpirinixic acid results in decreased expression of CDC25C protein19748123
C006253pirinixic acidpirinixic acid results in increased expression of CDC25C mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of CDC25C mRNA]17950772
D010936Plant Extractsalpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of CDC25C mRNA]25051199
D010936Plant Extractsmanumycin inhibits the reaction [Plant Extracts results in decreased expression of CDC25C mRNA]25051199
D010936Plant ExtractsPlant Extracts results in decreased expression of CDC25C mRNA25051199
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CDC25C mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CDC25C mRNA22079256
C005556propionaldehydepropionaldehyde results in decreased expression of CDC25C mRNA26079696
C432165pyrazolanthrone"pyrazolanthrone inhibits the reaction [5-(2,4-dihydroxybenzylidene)-2-(phenylimino)-1,3-thiazolidin affects the expression of CDC25C protein]"16179969
D011794QuercetinQuercetin metabolite results in increased phosphorylation of CDC25C protein16280456
D011794QuercetinQuercetin results in decreased expression of CDC25C mRNA21632981|2372791
C059514resveratrolCaffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDC25C protein]15975956
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CDC25C mRNA19167446
C059514resveratrol[resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]] which results in increased phosphorylation of CDC25C protein15975956
C059514resveratrolresveratrol results in increased phosphorylation of CDC25C protein15975956
C547185riccardin Driccardin D results in decreased expression of CDC25C mRNA24069304
C547185riccardin Driccardin D results in decreased expression of CDC25C protein24069304
C093642SB 203580SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein]22230261
C093642SB 203580SB 203580 inhibits the reaction [ochratoxin A results in decreased expression of CDC25C protein modified form]22230261
D017655Silicon CompoundsSilicon Compounds results in decreased expression of CDC25C protein23620807
D012834SilverNFE2L2 protein affects the reaction [Silver results in increased phosphorylation of CDC25C protein]22546375
D012834SilverSilver results in increased phosphorylation of CDC25C protein22546375
D012835Silver NitrateSilver Nitrate analog affects the expression of CDC25C mRNA22831968
C009277sodium arsenate[CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate20025242
C017947sodium arsenitesodium arsenite results in decreased expression of CDC25C protein16614167
C017947sodium arsenitesodium arsenite results in decreased expression of CDC25C mRNA17998272
D013241SterigmatocystinMLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDC25C protein]23296099
D013241SterigmatocystinMLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDC25C protein modified form]23296099
D013241SterigmatocystinSterigmatocystin results in increased expression of CDC25C mRNA23296099
D013241SterigmatocystinSterigmatocystin results in increased expression of CDC25C protein23296099
D013241SterigmatocystinSterigmatocystin results in increased expression of CDC25C protein modified form23296099
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CDC25C mRNA"26680231
C112765tanespimycin[tanespimycin co-treated with NQO1 protein] results in decreased expression of CDC25C protein21156818
C047246temozolomideAKT1 protein inhibits the reaction [temozolomide results in increased phosphorylation of and results in decreased activity of CDC25C protein]15930307
C047246temozolomidetemozolomide results in increased phosphorylation of and results in decreased activity of CDC25C protein15930307
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CDC25C mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CDC25C mRNA21592394
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of CDC25C mRNA19074003
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDC25C protein]22266097
D013749TetrachlorodibenzodioxinMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDC25C protein]22266097
D013749TetrachlorodibenzodioxinPGR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDC25C protein]22266097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDC25C mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of CDC25C protein22266097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDC25C mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC25C mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDC25C mRNA22298810
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of CDC25C protein21375462
D013853ThioacetamideThioacetamide affects the localization of CDC25C protein22659510
D013853ThioacetamideThioacetamide results in increased expression of CDC25C mRNA22659510
C011559tributyltindimethyl alpha-ketoglutarate inhibits the reaction [tributyltin results in decreased expression of CDC25C protein]26961604
C011559tributyltinIDH3A protein affects the reaction [tributyltin results in decreased expression of CDC25C protein]26961604
C011559tributyltintributyltin results in decreased expression of CDC25C protein26961604
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDC25C mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CDC25C mRNA24935251|2627250
C020946triethylene glycol dimethacrylatetriethylene glycol dimethacrylate results in decreased expression of CDC25C mRNA22486746
C020946triethylene glycol dimethacrylatetriethylene glycol dimethacrylate results in decreased expression of CDC25C protein22486746
C015559trimellitic anhydridetrimellitic anhydride affects the expression of CDC25C mRNA22302311
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CDC25C mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of CDC25C mRNA19140230
D014520UrethaneUrethane results in increased expression of CDC25C mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CDC25C mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CDC25C mRNA23179753|2800136
D014638VanadatesTRP53 protein affects the reaction [Vanadates affects the degradation of CDC25C protein]12435075
D014638VanadatesVanadates affects the degradation of CDC25C protein12435075
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of CDC25C mRNA27169980
C025643vinclozolinvinclozolin results in decreased expression of CDC25C mRNA23555832
C111237vorinostatvorinostat results in increased expression of CDC25C mRNA27188386
C022186xanthatinbafilomycin A1 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]29074359
C022186xanthatinGo 6976 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]29074359
C022186xanthatinleupeptin inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]29074359
C022186xanthatinTP53 protein promotes the reaction [xanthatin results in decreased expression of CDC25C protein modified form]29074359
C022186xanthatinTP53 protein promotes the reaction [xanthatin results in decreased stability of CDC25C protein]29074359
C022186xanthatinxanthatin results in decreased expression of CDC25C protein modified form29074359
C022186xanthatinxanthatin results in increased ubiquitination of and results in decreased stability of CDC25C protein29074359
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of CDC25C mRNA16357179
C000588918ziyuglycoside IIziyuglycoside II results in decreased expression of and results in increased phosphorylation of CDC25C protein24680927
C088658zoledronic acidzoledronic acid results in increased expression of CDC25C mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004721phosphoprotein phosphatase activity-TAS-  
GO:0004725protein tyrosine phosphatase activity-IBA21873635  
GO:0004725protein tyrosine phosphatase activity-NAS11078813  
GO:0005515protein binding-IPI9543386  11836499  12595692  14532005  16330544  17110335  
17307877  17349584  18056802  19470455  19597481  24255178  
28330616  
GO:0019901protein kinase binding-IPI9543386  14968113  
GO:0050699WW domain binding-IPI10037602  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-TAS11139144  
GO:0000086G2/M transition of mitotic cell cycle-IBA21873635  
GO:0000086G2/M transition of mitotic cell cycle-IGI2195549  
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0007088regulation of mitotic nuclear division-TAS1828290  
GO:0007283spermatogenesis-IEA-  
GO:0008283cell proliferation-TAS11139144  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-IBA21873635  
GO:0016032viral process-IEA-  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO:0045931positive regulation of mitotic cell cycle-IBA21873635  
GO:0051301cell division-IEA-  
GO:0110032positive regulation of G2/MI transition of meiotic cell cycle-IBA21873635  
GO:1902751positive regulation of cell cycle G2/M phase transition-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA14968113  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0016607nuclear speck-IDA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-156711Polo-like kinase mediated eventsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-176187Activation of ATR in response to replication stressTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5625740RHO GTPases activate PKNsTAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestTAS
R-HSA-6804115TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainTAS
R-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexTAS
R-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsTAS
R-HSA-8863678Neurodegenerative DiseasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16283383Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines. (2006 Mar)Senju MJ Cancer Res Clin Oncol
23470146Overexpression of Cdc25C predicts response to radiotherapy and survival in esophageal squamous cell carcinoma patients treated with radiotherapy followed by surgery. (2013 Jul)Li BZChin J Cancer