Gene: MVP

9961
LRP|VAULT1
major vault protein
protein-coding
16p11.2
Ensembl:ENSG00000013364 MIM:605088 Vega:OTTHUMG00000048227 UniprotKB:Q14764
NC_000016.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.384e-2 (AD)  5.053e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09010156chr16:29836211MVP3.000e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RRBP10.898
EFNA10.898
LMNA0.895
SERPINB10.879
STAT5A0.877
SLC39A10.872
SYNGR20.866
DNAJC10.863
TAGLN20.862
IFITM30.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.52
HAPLN1-0.516
KIT-0.513
CRH-0.496
ADRA1D-0.495
VWC2-0.495
ABCC12-0.492
FBLN7-0.49
SLC7A4-0.484
NEUROD6-0.482

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MVP mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MVP mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MVP mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of MVP mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of MVP mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MVP mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MVP mRNA]17585979
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of MVP protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MVP mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of MVP mRNA"22863853
D000970Antineoplastic AgentsMVP protein results in decreased susceptibility to Antineoplastic Agents11937269
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MVP mRNA24449571
D001151ArsenicArsenic affects the methylation of MVP gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of MVP protein25419056
D001280AtrazineAtrazine results in increased expression of MVP mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MVP mRNA20106945|2163298
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in decreased expression of MVP protein modified form24464499
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in increased expression of MVP protein modified form24464499
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MVP mRNA22228805
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Copper] results in increased expression of MVP protein24211336
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MVP mRNA22300585
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MVP protein21467743
C006780bisphenol Abisphenol A results in increased expression of MVP mRNA20826375
C006780bisphenol Abisphenol A results in increased expression of MVP mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of MVP protein28903499
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MVP mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of MVP promoter22457795
D002220CarbamazepineCarbamazepine results in decreased expression of MVP mRNA19632730
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MVP mRNA27339419
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of MVP mRNA18636392
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MVP mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MVP mRNA]17585979
D002994ClofibrateClofibrate results in increased expression of MVP mRNA22300585
D003300Copper[Benzo(a)pyrene co-treated with Copper] results in increased expression of MVP protein24211336
D019327Copper SulfateCopper Sulfate results in increased expression of MVP mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MVP mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of MVP mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of MVP mRNA19167446
D003471CuprizoneCuprizone results in increased expression of MVP mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of MVP mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of MVP mRNA25562108
D003524CyclosporinsCyclosporins affects the activity of MVP protein15788683
D003703DemecolcineDemecolcine results in increased expression of MVP mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MVP mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MVP mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of MVP mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of MVP mRNA18042831|2260994
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MVP mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of MVP mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MVP mRNA18544905
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MVP mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of MVP mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MVP mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of MVP mRNA25380136
D004147DioxinsDioxins affects the expression of MVP mRNA20463971
D004317DoxorubicinMVP protein affects the susceptibility to Doxorubicin17575109
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of MVP mRNA18851785
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MVP mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MVP mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MVP mRNA23649840
D005472FluorouracilFluorouracil promotes the reaction [YBX1 protein binds to MVP promoter]15750632
D005472FluorouracilFluorouracil results in increased expression of MVP mRNA15750632
D005472FluorouracilFluorouracil results in increased expression of MVP protein15750632
D005485FlutamideFlutamide results in decreased expression of MVP mRNA24793618
D005485FlutamideFlutamide results in increased expression of MVP mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of MVP mRNA23649840
D005839GentamicinsGentamicins results in increased expression of MVP mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of MVP mRNA22634610
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MVP mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MVP mRNA27392435
C544151jinfukangjinfukang results in increased expression of MVP mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MVP mRNA26752646
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MVP mRNA18544905
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MVP mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MVP mRNA27339419
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MVP mRNA25613284
C005095malachite greenmalachite green results in increased expression of MVP protein22446826
D015122MercaptopurineMVP results in decreased susceptibility to Mercaptopurine19232821
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of MVP mRNA17083914
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MVP mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MVP mRNA17083914
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MVP mRNA23649840
D008774MethylphenidateMethylphenidate results in decreased expression of MVP mRNA22470460
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of MVP mRNA24128854
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MVP mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MVP mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of MVP mRNA25380136
D009532NickelNickel results in increased expression of MVP mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of MVP mRNA19167457
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of MVP mRNA18636392
D000073878Palm OilPalm Oil results in increased expression of MVP mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of MVP mRNA23892564
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MVP mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of MVP mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MVP mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MVP mRNA18301758|2381119
D011192Potassium DichromatePotassium Dichromate results in increased expression of MVP protein23718831
D011441PropylthiouracilPropylthiouracil results in decreased expression of MVP mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of MVP mRNA27029645
D011794QuercetinQuercetin results in increased expression of MVP mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of MVP mRNA19167446
C059514resveratrolresveratrol results in increased expression of MVP mRNA25905778
C541923sandostatinLARsandostatinLAR results in increased expression of MVP mRNA17210224
D012643SeleniumSelenium results in increased expression of MVP mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of MVP mRNA23221170
C017947sodium arsenitesodium arsenite results in increased expression of MVP mRNA22714537
D012999SomanSoman results in increased expression of MVP mRNA19281266
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in decreased expression of MVP protein modified form24464499
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in increased expression of MVP protein modified form24464499
D053260SootSoot results in decreased expression of MVP protein24464499
D053260SootSoot results in decreased expression of MVP protein modified form24464499
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MVP mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MVP mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MVP mRNA15716485
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MVP mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MVP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MVP mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MVP mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of MVP mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MVP mRNA28065790
D014212TretinoinTretinoin results in increased expression of MVP mRNA18230668
C012589trichostatin Atrichostatin A results in increased expression of MVP mRNA15901671
C510683tripeptide tyroservatidetripeptide tyroservatide results in decreased expression of MVP mRNA18538471
C510683tripeptide tyroservatidetripeptide tyroservatide results in decreased expression of MVP protein18538471
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of MVP mRNA29024780
C057693troglitazonetroglitazone results in increased expression of MVP mRNA19140230
D014415TunicamycinTunicamycin results in increased expression of MVP mRNA22378314
C113580U 0126U 0126 results in decreased expression of MVP mRNA15526378
D014635Valproic AcidValproic Acid results in increased expression of MVP mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of MVP mRNA29154799
D014638VanadatesVanadates results in increased expression of MVP mRNA22714537
D014640VancomycinVancomycin results in decreased expression of MVP mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MVP gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of MVP mRNA16341940
C025643vinclozolinvinclozolin affects the expression of MVP mRNA19015723
D014750VincristineVincristine results in increased expression of MVP mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of MVP mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of MVP mRNA20977926
C088658zoledronic acidzoledronic acid results in increased expression of MVP mRNA18225567

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15133037  16815308  18809583  
GO:0019901protein kinase binding-IPI16441665  
GO:0019903protein phosphatase binding-IDA15133037  
GO:0042802identical protein binding-IPI21988832  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0015031protein transport-IEA-  
GO:0023051regulation of signaling-IBA21873635  
GO:0023057negative regulation of signaling-IDA16441665  
GO:0031953negative regulation of protein autophosphorylation-IDA16441665  
GO:0038127ERBB signaling pathway-IDA15133037  
GO:0043312neutrophil degranulation-TAS-  
GO:0051028mRNA transport-IEA-  
GO:0061099negative regulation of protein tyrosine kinase activity-IDA16441665  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA15133037  16441665  
GO:0005643nuclear pore-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA16441665  
GO:0005829cytosol-IDA-  
GO:0005856cytoskeleton-IDA16441665  
GO:0016020membrane-HDA19946888  
GO:0034774secretory granule lumen-TAS-  
GO:0048471perinuclear region of cytoplasm-IDA16441665  
GO:0070062extracellular exosome-HDA19056867  19199708  20458337  21362503  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
3743165Embolic stroke in a woman with mitral valve prolapse who used oral contraceptives. (1986 Sep)Busch EHChest
17459603Tumor expression of major vault protein is an adverse prognostic factor for radiotherapy outcome in oropharyngeal carcinoma. (2007 Sep 1)Silva PInt J Radiat Oncol Biol Phys