Gene: SLC23A2

9962
NBTL1|SLC23A1|SVCT2|YSPL2
solute carrier family 23 member 2
protein-coding
20p13
Ensembl:ENSG00000089057 MIM:603791 Vega:OTTHUMG00000031793 UniprotKB:Q9UGH3
NG_029959.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.830e-1 (AD)  7.593e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16547579chr20:4954333SLC23A22.000e-10Maternal smoking in pregnancy27040690
cg16547579chr20:4954333SLC23A23.320e-10Maternal smoking in pregnancy27040690
cg16547579chr20:4954333SLC23A26.020e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM168A0.911
DDB10.909
ASTN10.9
USP220.896
ASB80.895
ABR0.894
EXOC70.894
FOXRED20.894
PRRC2A0.893
APLP20.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.699
OR4F29-0.649
CLEC2B-0.347
C19orf33-0.343
PPBP-0.339
CSAG1-0.338
TFPI2-0.333
SPINK8-0.331
MTRNR2L6-0.328
CD48-0.324

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SLC23A2 mRNA"21354444|2269881
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC23A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC23A2 mRNA"27188386
C0685726-deoxy-6-bromoascorbic acidSLC23A2 protein affects the transport of 6-deoxy-6-bromoascorbic acid15590689
D000082AcetaminophenAcetaminophen results in decreased expression of SLC23A2 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of SLC23A2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SLC23A2 mRNA17562736
D000393Air PollutantsAir Pollutants analog results in decreased expression of SLC23A2 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC23A2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC23A2 mRNA24449571
D001151ArsenicArsenic affects the methylation of SLC23A2 gene25304211
C015001arsenitearsenite results in increased methylation of SLC23A2 promoter23974009
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [nickel sulfate results in decreased expression of SLC23A2 mRNA]16288478
D001205Ascorbic AcidDiclofenac inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D001205Ascorbic AcidEstradiol inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D001205Ascorbic AcidGenistein inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D001205Ascorbic AcidHydrocortisone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D001205Ascorbic AcidIndomethacin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D001205Ascorbic AcidProgesterone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D001205Ascorbic AcidQuercetin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D001205Ascorbic AcidAscorbic Acid deficiency results in increased expression of SLC23A2 protein22001929
D001205Ascorbic AcidAscorbic Acid results in increased expression of SLC23A2 mRNA20122894
D001205Ascorbic AcidSLC23A2 mRNA results in increased abundance of Ascorbic Acid22558179
D001205Ascorbic AcidAscorbic Acid results in decreased expression of SLC23A2 mRNA19418264
D001205Ascorbic AcidSLC23A2 protein results in increased transport of Ascorbic Acid19418264
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC23A2 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC23A2 mRNA22228805
D004958EstradiolEstradiol inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D001663BilirubinBilirubin results in increased expression of SLC23A2 mRNA18706437
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of SLC23A2 mRNA15912405
C006780bisphenol Abisphenol A results in increased methylation of SLC23A2 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of SLC23A2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC23A2 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of SLC23A2 mRNA26079696
D002118CalciumCalcium deficiency results in decreased expression of SLC23A2 mRNA12788230
D002118CalciumCalcium results in increased expression of SLC23A2 mRNA12788230
D002118CalciumCalcium results in increased expression of SLC23A2 protein12788230
D002118CalciumFoscarnet inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]12788230
D002118CalciumNifedipine inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]12788230
D002220CarbamazepineCarbamazepine affects the expression of SLC23A2 mRNA25979313
D002220CarbamazepineCarbamazepine results in increased expression of SLC23A2 mRNA17112801
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SLC23A2 mRNA17484886
D002737ChloropreneChloroprene results in increased expression of SLC23A2 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC23A2 mRNA19320972|1937684
D016572CyclosporineCyclosporine results in increased expression of SLC23A2 mRNA25562108
C093628cyproconazolecyproconazole results in increased expression of SLC23A2 mRNA22334560
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC23A2 mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SLC23A2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SLC23A2 mRNA27392435
D004008DiclofenacDiclofenac inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
C000944dicrotophosdicrotophos results in increased expression of SLC23A2 mRNA28302478
C109476epoxiconazoleepoxiconazole results in increased expression of SLC23A2 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC23A2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC23A2 mRNA17942748
C026098etiracetametiracetam results in increased expression of SLC23A2 mRNA20345932
D005485FlutamideFlutamide results in decreased expression of SLC23A2 mRNA24793618
D017245FoscarnetFoscarnet inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]12788230
D017245FoscarnetFoscarnet inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]12788230
C039281furanfuran results in decreased expression of SLC23A2 mRNA24183702
D019833GenisteinGenistein inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D005944GlucosamineGlucosamine results in increased expression of SLC23A2 mRNA17109745
D006854HydrocortisoneHydrocortisone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of SLC23A2 mRNA19376150
D007213IndomethacinIndomethacin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC23A2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SLC23A2 mRNA25613284
D007501IronIron deficiency results in increased expression of SLC23A2 mRNA16629162
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC23A2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SLC23A2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SLC23A2 mRNA24796395
D007854LeadLead affects the expression of SLC23A2 mRNA28903495
C045463leflunomideleflunomide results in increased expression of SLC23A2 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLC23A2 mRNA26011545
D009020MorphineMorphine results in decreased expression of SLC23A2 mRNA19418264
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC23A2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC23A2 mRNA"25554681|2562005
C029938nickel sulfateAscorbic Acid inhibits the reaction [nickel sulfate results in decreased expression of SLC23A2 mRNA]16288478
C029938nickel sulfatenickel sulfate results in decreased expression of SLC23A2 mRNA16288478|2271453
D009543NifedipineNifedipine inhibits the reaction [Calcium results in increased expression of SLC23A2 mRNA]12788230
D009543NifedipineNifedipine inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]12788230
D010126OzoneGCLM gene mutant form promotes the reaction [Ozone results in increased expression of SLC23A2 mRNA]20417186
C016030pantogabpantogab results in increased expression of SLC23A2 mRNA17379144
D010269ParaquatParaquat results in decreased expression of SLC23A2 mRNA22558179
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SLC23A2 mRNA18593933
D010634PhenobarbitalPhenobarbital results in increased expression of SLC23A2 mRNA23091169
D010710PhosphatesFoscarnet inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]12788230
D010710PhosphatesNifedipine inhibits the reaction [Phosphates results in increased expression of SLC23A2 mRNA]12788230
D010710PhosphatesPhosphates deficiency results in decreased expression of SLC23A2 mRNA12788230
D010710PhosphatesPhosphates results in increased expression of SLC23A2 mRNA12788230
D010710PhosphatesPhosphates results in increased expression of SLC23A2 protein12788230
C006253pirinixic acidpirinixic acid results in increased expression of SLC23A2 mRNA17426115|1830175
D011374ProgesteroneProgesterone inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
C045950propiconazolepropiconazole results in increased expression of SLC23A2 mRNA21278054|2233456
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC23A2 mRNA24780913
D011794QuercetinQuercetin inhibits the reaction [SLC23A2 protein results in increased uptake of Ascorbic Acid]17092984
D012293RifampinRifampin results in increased expression of SLC23A2 mRNA27199754
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC23A2 mRNA25895662
D013656Taurocholic AcidTaurocholic Acid results in increased expression of SLC23A2 mRNA18706437
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC23A2 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC23A2 mRNA11489354|1968428
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC23A2 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of SLC23A2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of SLC23A2 mRNA23557971
D014050TolueneToluene affects the expression of SLC23A2 mRNA18653662
D014241TrichloroethyleneTrichloroethylene results in increased expression of SLC23A2 mRNA25549359
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC23A2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLC23A2 mRNA26272509
C057693troglitazonetroglitazone results in decreased expression of SLC23A2 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of SLC23A2 mRNA17127020
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of SLC23A2 mRNA18706437
D014635Valproic AcidValproic Acid affects the expression of SLC23A2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SLC23A2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SLC23A2 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC23A2 gene25560391
D015215ZidovudineZidovudine results in increased expression of SLC23A2 mRNA24292225
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SLC23A2 mRNA18593933
C088658zoledronic acidzoledronic acid results in increased expression of SLC23A2 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008520L-ascorbate:sodium symporter activity-IBA21873635  
GO:0015205nucleobase transmembrane transporter activity-TAS9804989  
GO:0015229L-ascorbic acid transmembrane transporter activity-IDA10631088  18247577  18417304  19216494  
GO:0015229L-ascorbic acid transmembrane transporter activity-TAS-  
GO:0070890sodium-dependent L-ascorbate transmembrane transporter activity-IBA21873635  
GO:0070890sodium-dependent L-ascorbate transmembrane transporter activity-IDA10471399  10631088  15993839  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS9804989  
GO:0006814sodium ion transport-IEA-  
GO:0006979response to oxidative stress-IBA21873635  
GO:0006979response to oxidative stress-IEA-  
GO:0015851nucleobase transport-TAS9804989  
GO:0015882L-ascorbic acid transmembrane transport-IDA10471399  10631088  18247577  18417304  19216494  
GO:0019852L-ascorbic acid metabolic process-IBA21873635  
GO:0019852L-ascorbic acid metabolic process-NAS10556521  
GO:0019852L-ascorbic acid metabolic process-TAS-  
GO:0070904transepithelial L-ascorbic acid transport-IBA21873635  
GO:0070904transepithelial L-ascorbic acid transport-IDA18417304  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA10631088  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0009925basal plasma membrane-IBA21873635  
GO:0009925basal plasma membrane-IEA-  
GO:0016020membrane-TAS9804989  
GO:0016021integral component of membrane-IC10471399  
GO:0016323basolateral plasma membrane-IDA15993839  18247577  18417304  19216494  
GO:0016324apical plasma membrane-IBA21873635  
GO:0016324apical plasma membrane-IDA18417304  
GO:0043292contractile fiber-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196836Vitamin C (ascorbate) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24932237SLC23A2-05 (rs4987219) and KRAS-LCS6 (rs61764370) polymorphisms in patients with squamous cell carcinoma of the head and neck. (2014 Jun)Santiago MBOncol Lett
24708273SLC23A1 polymorphism rs6596473 in the vitamin C transporter SVCT1 is associated with aggressive periodontitis. (2014 Jun)de Jong TMJ Clin Periodontol